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• W4213163481 endingPage "1057" @default.
• W4213163481 startingPage "1057" @default.
• W4213163481 abstract "Immune checkpoint inhibitors (ICI) prolong the survival in an increasing number of patients affected by several malignancies, but at the cost of new toxicities related to their mechanisms of action, autoimmunity. Endocrine toxicity frequently occurs in patients on ICI, but endocrine dysfunctions differ based on the ICI-subclass, as follows: agents targeting the CTLA4-receptor often induce hypophysitis and rarely thyroid dysfunction, which is the opposite for agents targeting the PD-1/PD-L1 axis. Recently, few cases of central diabetes insipidus have been reported as an adverse event induced by both ICI-subclasses, either in the context of anterior hypophysitis or as selective damage to the posterior pituitary or in the context of hypothalamitis. These new occurrences demonstrate, for the first time, that ICI-induced autoimmunity may involve any tract of the hypothalamic-pituitary axis. However, the related pathogenic mechanisms remain to be fully elucidated. Similarly, the data explaining the endocrine system susceptibility to primary and ICI-induced autoimmunity are still scarce. Since ICI clinical indications are expected to expand in the near future, ICI-induced autoimmunity to the hypothalamic-pituitary axis presents as a unique in vivo model that could help to clarify the pathogenic mechanisms underlying both the dysfunction induced by ICI to the hypothalamus-pituitary axis and primary autoimmune diseases affecting the same axis." @default.
• W4213163481 created "2022-02-24" @default.
• W4213163481 creator A5005594699 @default.
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• W4213163481 creator A5074839378 @default.
• W4213163481 date "2022-02-18" @default.
• W4213163481 modified "2023-10-03" @default.
• W4213163481 title "Immune Checkpoint Inhibitors as a Threat to the Hypothalamus–Pituitary Axis: A Completed Puzzle" @default.
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• W4213163481 doi "https://doi.org/10.3390/cancers14041057" @default.
• W4213163481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35205804" @default.
• W4213163481 hasPublicationYear "2022" @default.
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