Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213178911> ?p ?o ?g. }
- W4213178911 endingPage "233" @default.
- W4213178911 startingPage "233" @default.
- W4213178911 abstract "The widespread irrational use of antibiotics in recent years has resulted in an increase in the detection of multi-resistant bacterial strains, particularly methicillin-resistant Staphylococcus aureus (MRSA). The use of natural derivatives such as flavonoids is postulated as one of the most promising avenues to solve this emerging public health problem. The objective of the present study is to characterize the antimicrobial activity of icariin, a flavonoid compound isolated from a variety of plants of the Epimedium genus, against human and animal clinical MRSA isolates. Our study found that icariin alone did not have any antimicrobial effect on S. aureus or MRSA clinical isolates. However, icariin enhanced the effect of amoxycillin-clavulanate or ampicillin, whereas no effect was seen when used in combination with vancomycin. Specifically, co-incubation of S. aureus with amoxycillin-clavulanate plus icariin resulted in an increased proportion of dead cells, suggesting that this flavonoid potentially increases antimicrobial activity when used in combination with the beta-lactam antibiotic amoxycillin-clavulanate. Furthermore, we demonstrate that co-incubation of S. aureus with AmoxyClav plus icariin resulted in increased membrane disruption and growth inhibition. This study demonstrates the potential utility of icariin in permitting lower antibiotic therapeutic doses in alignment with strategies to reduce the spread of antibiotic resistance. Further research is required to determine the optimum concentration of icariin and to define clinically relevant combinations of flavonoid and antibiotic." @default.
- W4213178911 created "2022-02-24" @default.
- W4213178911 creator A5037588993 @default.
- W4213178911 creator A5044033265 @default.
- W4213178911 creator A5058451221 @default.
- W4213178911 creator A5066478049 @default.
- W4213178911 creator A5090056703 @default.
- W4213178911 date "2022-02-11" @default.
- W4213178911 modified "2023-10-18" @default.
- W4213178911 title "Icariin in Combination with Amoxycillin-Clavulanate and Ampicillin, but Not Vancomycin, Increases Antibiotic Sensitivity and Growth Inhibition against Methicillin-Resistant Staphylococcus aureus" @default.
- W4213178911 cites W1971201539 @default.
- W4213178911 cites W1973866638 @default.
- W4213178911 cites W1975354698 @default.
- W4213178911 cites W1982680862 @default.
- W4213178911 cites W1991849733 @default.
- W4213178911 cites W1993373215 @default.
- W4213178911 cites W2019275603 @default.
- W4213178911 cites W2020490655 @default.
- W4213178911 cites W2021624508 @default.
- W4213178911 cites W2023167090 @default.
- W4213178911 cites W2033491946 @default.
- W4213178911 cites W2039319582 @default.
- W4213178911 cites W2054606782 @default.
- W4213178911 cites W2065935900 @default.
- W4213178911 cites W2067817830 @default.
- W4213178911 cites W2092987378 @default.
- W4213178911 cites W2113337534 @default.
- W4213178911 cites W2115590616 @default.
- W4213178911 cites W2122757075 @default.
- W4213178911 cites W2134000175 @default.
- W4213178911 cites W2140942820 @default.
- W4213178911 cites W2562627217 @default.
- W4213178911 cites W2748001629 @default.
- W4213178911 cites W2793474951 @default.
- W4213178911 cites W2887252069 @default.
- W4213178911 cites W2892224462 @default.
- W4213178911 cites W2894180419 @default.
- W4213178911 cites W2896187181 @default.
- W4213178911 cites W3024325666 @default.
- W4213178911 cites W3093618986 @default.
- W4213178911 doi "https://doi.org/10.3390/antibiotics11020233" @default.
- W4213178911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35203835" @default.
- W4213178911 hasPublicationYear "2022" @default.
- W4213178911 type Work @default.
- W4213178911 citedByCount "1" @default.
- W4213178911 crossrefType "journal-article" @default.
- W4213178911 hasAuthorship W4213178911A5037588993 @default.
- W4213178911 hasAuthorship W4213178911A5044033265 @default.
- W4213178911 hasAuthorship W4213178911A5058451221 @default.
- W4213178911 hasAuthorship W4213178911A5066478049 @default.
- W4213178911 hasAuthorship W4213178911A5090056703 @default.
- W4213178911 hasBestOaLocation W42131789111 @default.
- W4213178911 hasConcept C142724271 @default.
- W4213178911 hasConcept C204787440 @default.
- W4213178911 hasConcept C2776021129 @default.
- W4213178911 hasConcept C2778980435 @default.
- W4213178911 hasConcept C2779489039 @default.
- W4213178911 hasConcept C2779708577 @default.
- W4213178911 hasConcept C2780685212 @default.
- W4213178911 hasConcept C4937899 @default.
- W4213178911 hasConcept C501593827 @default.
- W4213178911 hasConcept C523546767 @default.
- W4213178911 hasConcept C54355233 @default.
- W4213178911 hasConcept C71924100 @default.
- W4213178911 hasConcept C86803240 @default.
- W4213178911 hasConcept C89423630 @default.
- W4213178911 hasConcept C94665300 @default.
- W4213178911 hasConcept C98274493 @default.
- W4213178911 hasConceptScore W4213178911C142724271 @default.
- W4213178911 hasConceptScore W4213178911C204787440 @default.
- W4213178911 hasConceptScore W4213178911C2776021129 @default.
- W4213178911 hasConceptScore W4213178911C2778980435 @default.
- W4213178911 hasConceptScore W4213178911C2779489039 @default.
- W4213178911 hasConceptScore W4213178911C2779708577 @default.
- W4213178911 hasConceptScore W4213178911C2780685212 @default.
- W4213178911 hasConceptScore W4213178911C4937899 @default.
- W4213178911 hasConceptScore W4213178911C501593827 @default.
- W4213178911 hasConceptScore W4213178911C523546767 @default.
- W4213178911 hasConceptScore W4213178911C54355233 @default.
- W4213178911 hasConceptScore W4213178911C71924100 @default.
- W4213178911 hasConceptScore W4213178911C86803240 @default.
- W4213178911 hasConceptScore W4213178911C89423630 @default.
- W4213178911 hasConceptScore W4213178911C94665300 @default.
- W4213178911 hasConceptScore W4213178911C98274493 @default.
- W4213178911 hasIssue "2" @default.
- W4213178911 hasLocation W42131789111 @default.
- W4213178911 hasLocation W42131789112 @default.
- W4213178911 hasLocation W42131789113 @default.
- W4213178911 hasLocation W42131789114 @default.
- W4213178911 hasLocation W42131789115 @default.
- W4213178911 hasOpenAccess W4213178911 @default.
- W4213178911 hasPrimaryLocation W42131789111 @default.
- W4213178911 hasRelatedWork W1603282463 @default.
- W4213178911 hasRelatedWork W2022769258 @default.
- W4213178911 hasRelatedWork W2382345126 @default.
- W4213178911 hasRelatedWork W2885262055 @default.
- W4213178911 hasRelatedWork W2954159082 @default.
- W4213178911 hasRelatedWork W2978793169 @default.