FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213190654> ?p ?o ?g. }

• W4213190654 endingPage "222" @default.
• W4213190654 startingPage "205" @default.
• W4213190654 abstract "Understanding how the tumor microenvironment is shaped by various factors is important for the development of new therapeutic strategies. Tumor cells often undergo spontaneous apoptotic cell death in tumor microenvironment, these apoptotic cells are histologically co-localized with immunosuppressive macrophages. However, the mechanism by which tumor cell apoptosis modulates macrophage polarization is not fully understood. In this study, we aimed to explore the tumor promoting effects of apoptotic tumor cells and the signal pathways involved.Apoptotic cells and macrophages in tumors were detected by immunohistochemical staining. Morphological analysis was performed with Giemsa staining. Lipids generated from apoptotic cells were detected by liquid chromatography-mass spectrometry. Phosphatidylserine-containing liposomes were prepared to mimic apoptotic cells. The expression of protein was determined by real-time PCR, immunohistochemistry enzyme-linked immunosorbent assay and Western blotting. Mouse malignant ascites and subcutaneous tumor models were designed for in vivo analysis. Transgenic mice with specific genes knocked out and inhibitors specific to certain proteins were used for the mechanistic studies.The location and the number of apoptotic cells were correlated with that of macrophages in several types of carcinomas. Phosphatidylserine, a lipid molecule generated in apoptotic cells, induced polarization and accumulation of M2-like macrophages in vivo and in vitro. Moreover, sustained administration of phosphoserine promoted tumor growth in the malignant ascites and subcutaneous tumor models. Further analyses suggested that phosphoserine induced a M2-like phenotype in macrophages, which was related to the activation of phosphoserine receptors including T-cell immunoglobin mucin 4 (TIM4) and the FAK-SRC-STAT3 signaling pathway as well as elevated the expression of the histone demethylase Jumonji domain-containing protein 3 (JMJD3). Administration of specific inhibitors of these pathways could reduce tumor progression.This study suggest that apoptotic cell-generated phosphoserine might be a notable signal for immunosuppressive macrophages in tumors, and the related pathways might be potential therapeutic targets for cancer therapy." @default.
• W4213190654 created "2022-02-24" @default.
• W4213190654 creator A5001504110 @default.
• W4213190654 creator A5006434354 @default.
• W4213190654 creator A5010783508 @default.
• W4213190654 creator A5015152606 @default.
• W4213190654 creator A5016051893 @default.
• W4213190654 creator A5032657316 @default.
• W4213190654 creator A5036597732 @default.
• W4213190654 creator A5043803955 @default.
• W4213190654 creator A5044966606 @default.
• W4213190654 creator A5045909068 @default.
• W4213190654 creator A5052651303 @default.
• W4213190654 creator A5061380624 @default.
• W4213190654 creator A5063089557 @default.
• W4213190654 date "2022-02-22" @default.
• W4213190654 modified "2023-10-13" @default.
• W4213190654 title "Phosphatidylserine released from apoptotic cells in tumor induces M2‐like macrophage polarization through the PSR‐STAT3‐JMJD3 axis" @default.
• W4213190654 cites W1497435349 @default.
• W4213190654 cites W1940048983 @default.
• W4213190654 cites W1940692702 @default.
• W4213190654 cites W1963665032 @default.
• W4213190654 cites W1964083798 @default.
• W4213190654 cites W1975815647 @default.
• W4213190654 cites W1976711842 @default.
• W4213190654 cites W1978224572 @default.
• W4213190654 cites W1983470102 @default.
• W4213190654 cites W1985915754 @default.
• W4213190654 cites W1991129425 @default.
• W4213190654 cites W2000217512 @default.
• W4213190654 cites W2001717792 @default.
• W4213190654 cites W2007820695 @default.
• W4213190654 cites W2007840001 @default.
• W4213190654 cites W2008735740 @default.
• W4213190654 cites W2017558201 @default.
• W4213190654 cites W2031259207 @default.
• W4213190654 cites W2038709381 @default.
• W4213190654 cites W2049263710 @default.
• W4213190654 cites W2050419005 @default.
• W4213190654 cites W2050468052 @default.
• W4213190654 cites W2058648826 @default.
• W4213190654 cites W2063632665 @default.
• W4213190654 cites W2068793888 @default.
• W4213190654 cites W2078165843 @default.
• W4213190654 cites W2078532650 @default.
• W4213190654 cites W2083870593 @default.
• W4213190654 cites W2107790283 @default.
• W4213190654 cites W2109260826 @default.
• W4213190654 cites W2123436498 @default.
• W4213190654 cites W2127514713 @default.
• W4213190654 cites W2131523916 @default.
• W4213190654 cites W2133536768 @default.
• W4213190654 cites W2136722399 @default.
• W4213190654 cites W2153071302 @default.
• W4213190654 cites W2161707000 @default.
• W4213190654 cites W2314735700 @default.
• W4213190654 cites W2474601761 @default.
• W4213190654 cites W2771932310 @default.
• W4213190654 cites W2785390423 @default.
• W4213190654 cites W2794609578 @default.
• W4213190654 cites W2889359271 @default.
• W4213190654 cites W2890107533 @default.
• W4213190654 cites W2890859804 @default.
• W4213190654 cites W2900429601 @default.
• W4213190654 cites W2907564726 @default.
• W4213190654 cites W2914311347 @default.
• W4213190654 cites W2942871705 @default.
• W4213190654 cites W3128931949 @default.
• W4213190654 cites W4213190654 @default.
• W4213190654 doi "https://doi.org/10.1002/cac2.12272" @default.
• W4213190654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35191227" @default.
• W4213190654 hasPublicationYear "2022" @default.
• W4213190654 type Work @default.
• W4213190654 citedByCount "13" @default.
• W4213190654 countsByYear W42131906542022 @default.
• W4213190654 countsByYear W42131906542023 @default.
• W4213190654 crossrefType "journal-article" @default.
• W4213190654 hasAuthorship W4213190654A5001504110 @default.
• W4213190654 hasAuthorship W4213190654A5006434354 @default.
• W4213190654 hasAuthorship W4213190654A5010783508 @default.
• W4213190654 hasAuthorship W4213190654A5015152606 @default.
• W4213190654 hasAuthorship W4213190654A5016051893 @default.
• W4213190654 hasAuthorship W4213190654A5032657316 @default.
• W4213190654 hasAuthorship W4213190654A5036597732 @default.
• W4213190654 hasAuthorship W4213190654A5043803955 @default.
• W4213190654 hasAuthorship W4213190654A5044966606 @default.
• W4213190654 hasAuthorship W4213190654A5045909068 @default.
• W4213190654 hasAuthorship W4213190654A5052651303 @default.
• W4213190654 hasAuthorship W4213190654A5061380624 @default.
• W4213190654 hasAuthorship W4213190654A5063089557 @default.
• W4213190654 hasBestOaLocation W42131906541 @default.
• W4213190654 hasConcept C11960822 @default.
• W4213190654 hasConcept C153911025 @default.
• W4213190654 hasConcept C185592680 @default.
• W4213190654 hasConcept C190283241 @default.
• W4213190654 hasConcept C202751555 @default.
• W4213190654 hasConcept C203014093 @default.
• W4213190654 hasConcept C2776107976 @default.

• next