Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213193954> ?p ?o ?g. }
- W4213193954 abstract "Severe insulin resistance syndromes are a heterogeneous group of rare disorders characterized by profound insulin resistance, substantial metabolic abnormalities, and a variety of clinical manifestations and complications. The etiology of these syndromes may be hereditary or acquired, due to defects in insulin potency and action, cellular responsiveness to insulin, and/or aberrations in adipose tissue function or development. Over the past decades, advances in medical technology, particularly in genomic technologies and genetic analyses, have provided insights into the underlying pathophysiological pathways and facilitated the more precise identification of several of these conditions. However, the exact cellular and molecular mechanisms of insulin resistance have not yet been fully elucidated for all syndromes. Moreover, in clinical practice, many of the syndromes are often misdiagnosed or underdiagnosed. The majority of these disorders associate with an increased risk of severe complications and mortality; thus, early identification and personalized clinical management are of the essence. This Review aims to categorize severe insulin resistance syndromes by disease process, including insulin receptor defects, signaling defects, and lipodystrophies. We also highlight several complex syndromes and emphasize the need to identify patients, investigate underlying disease mechanisms, and develop specific treatment regimens." @default.
- W4213193954 created "2022-02-24" @default.
- W4213193954 creator A5005766189 @default.
- W4213193954 creator A5058007715 @default.
- W4213193954 creator A5091056312 @default.
- W4213193954 date "2021-02-15" @default.
- W4213193954 modified "2023-10-18" @default.
- W4213193954 title "Severe insulin resistance syndromes" @default.
- W4213193954 cites W1526318802 @default.
- W4213193954 cites W1561622357 @default.
- W4213193954 cites W1602421905 @default.
- W4213193954 cites W1908352934 @default.
- W4213193954 cites W1965125798 @default.
- W4213193954 cites W1965126423 @default.
- W4213193954 cites W1966255241 @default.
- W4213193954 cites W1973706205 @default.
- W4213193954 cites W1974156337 @default.
- W4213193954 cites W1976081253 @default.
- W4213193954 cites W1977689678 @default.
- W4213193954 cites W1983654825 @default.
- W4213193954 cites W1987915813 @default.
- W4213193954 cites W1989263120 @default.
- W4213193954 cites W1989344342 @default.
- W4213193954 cites W1990282064 @default.
- W4213193954 cites W1990407738 @default.
- W4213193954 cites W1991150015 @default.
- W4213193954 cites W1992002046 @default.
- W4213193954 cites W1995994688 @default.
- W4213193954 cites W1997146974 @default.
- W4213193954 cites W1997281019 @default.
- W4213193954 cites W2000150763 @default.
- W4213193954 cites W2004366492 @default.
- W4213193954 cites W2009330135 @default.
- W4213193954 cites W2012567863 @default.
- W4213193954 cites W2013317654 @default.
- W4213193954 cites W2013990609 @default.
- W4213193954 cites W2014618027 @default.
- W4213193954 cites W2015130768 @default.
- W4213193954 cites W2015313377 @default.
- W4213193954 cites W2020803051 @default.
- W4213193954 cites W2022749561 @default.
- W4213193954 cites W2023716357 @default.
- W4213193954 cites W2024050954 @default.
- W4213193954 cites W2027002553 @default.
- W4213193954 cites W2027542164 @default.
- W4213193954 cites W2028539394 @default.
- W4213193954 cites W2031882974 @default.
- W4213193954 cites W2034711245 @default.
- W4213193954 cites W2036855737 @default.
- W4213193954 cites W2040850750 @default.
- W4213193954 cites W2041196365 @default.
- W4213193954 cites W2041557658 @default.
- W4213193954 cites W2048198423 @default.
- W4213193954 cites W2048331100 @default.
- W4213193954 cites W2049813983 @default.
- W4213193954 cites W2049827705 @default.
- W4213193954 cites W2051051060 @default.
- W4213193954 cites W2052222168 @default.
- W4213193954 cites W2053701857 @default.
- W4213193954 cites W2058588784 @default.
- W4213193954 cites W2058699849 @default.
- W4213193954 cites W2059275791 @default.
- W4213193954 cites W2059717716 @default.
- W4213193954 cites W2060416156 @default.
- W4213193954 cites W2063084087 @default.
- W4213193954 cites W2064555928 @default.
- W4213193954 cites W2064882076 @default.
- W4213193954 cites W2066961578 @default.
- W4213193954 cites W2068768095 @default.
- W4213193954 cites W2070618297 @default.
- W4213193954 cites W2072134824 @default.
- W4213193954 cites W2074076323 @default.
- W4213193954 cites W2076310317 @default.
- W4213193954 cites W2076706839 @default.
- W4213193954 cites W2076725143 @default.
- W4213193954 cites W2077411869 @default.
- W4213193954 cites W2077701646 @default.
- W4213193954 cites W2077830138 @default.
- W4213193954 cites W2083986466 @default.
- W4213193954 cites W2084310603 @default.
- W4213193954 cites W2084608105 @default.
- W4213193954 cites W2084967524 @default.
- W4213193954 cites W2085290879 @default.
- W4213193954 cites W2085657664 @default.
- W4213193954 cites W2086549112 @default.
- W4213193954 cites W2087454504 @default.
- W4213193954 cites W2089762118 @default.
- W4213193954 cites W2093904763 @default.
- W4213193954 cites W2094965785 @default.
- W4213193954 cites W2098025594 @default.
- W4213193954 cites W2102474919 @default.
- W4213193954 cites W2102529722 @default.
- W4213193954 cites W2103714496 @default.
- W4213193954 cites W2106327839 @default.
- W4213193954 cites W2107243354 @default.
- W4213193954 cites W2107940713 @default.
- W4213193954 cites W2109011155 @default.
- W4213193954 cites W2111033955 @default.
- W4213193954 cites W2111674103 @default.
- W4213193954 cites W2112644532 @default.