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• W4213202389 abstract "Abstract The innate immune response to inflammatory stimuli must be finely balanced to produce an appropriate pro-inflammatory response while allowing a subsequent return to homeostasis. In recent years, in vivo transgenic zebrafish models have shed light on the temporal regulation of the pro-inflammatory innate response to immune challenges. However, until now, there have been no zebrafish transgenic models of anti-inflammatory signalling. We compared existing expression data of arginase genes in zebrafish neutrophils and macrophages, strong candidates for an anti-inflammatory marker, and identified that arginase 2 is the most highly expressed Arginase in zebrafish immune cells. We developed an arginase 2 ( arg2 ) bacterial artificial chromosome (BAC) transgenic line, TgBAC(arg2:eGFP)sh571 , driving GFP expression under the control of the arg2 promoter. We show that, under resting conditions, arg2:GFP is expressed in ionocytes, matching the in situ hybridisation pattern. Upon immune challenge by injury, bacterial and fungal insults, arg2:GFP is predominantly expressed in neutrophils at early timepoints post-insult. Later in infections, arg2:GFP is expressed in cells associated with foci of infection (including neutrophils and macrophages), alongside liver expression. Our data indicate that arginase 2 is predominantly expressed in neutrophils after immune challenge and suggest that anti-inflammatory signals coincide with pro-inflammatory signals during early wound and infection responses." @default.
• W4213202389 created "2022-02-24" @default.
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• W4213202389 date "2022-02-14" @default.
• W4213202389 modified "2023-09-26" @default.
• W4213202389 title "An<i>arginase 2</i>promoter transgenic illuminates anti-inflammatory signalling in zebrafish" @default.
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• W4213202389 doi "https://doi.org/10.1101/2022.02.14.480079" @default.
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