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- W4213207675 abstract "Abstract Background Procalcitonin (PCT) is a biomarker which may have greater specificity than other pro-inflammatory markers in identifying bacterial infection and may aid in antimicrobial stewardship in COVID-19 patients. Methods A PCT assay by Abbott diagnostics was introduced in our hospital in November 2020. Over a 12 week period, we prospectively recorded all PCT results on in-patients with COVID-19 admitted to the ICU, as well as stewardship actions taken following discussion with the ICU physicians. Microbiology records were reviewed to ascertain whether bacterial infection was subsequently confirmed. Results Sixty-four PCT results were recorded on 27 patients (Table 1). Antimicrobials were discontinued on 12 occasions and withheld on 16 occasions where PCT was <0.5 ng/mL. No cases of confirmed bacterial infection were diagnosed in patients with PCT concentrations of <0.05 ng/mL; however definite bacterial infection was confirmed in two patients (one case of Staphylococcus aureus bloodstream infection; one case of Staphylococcus epidermidis CVC infection), and bacterial infection was designated probable in five patients with PCT ≥0.05 ng/mL and <0.5 ng/mL. Conclusions PCT may be a useful tool in enabling antimicrobial stewardship actions in patients with severe COVID-19, but results need to be interpreted within the clinical context." @default.
- W4213207675 created "2022-02-24" @default.
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- W4213207675 date "2022-02-01" @default.
- W4213207675 modified "2023-09-26" @default.
- W4213207675 title "P36 Procalcitonin as an antimicrobial stewardship tool in the COVID-19 era: a single centre experience" @default.
- W4213207675 doi "https://doi.org/10.1093/jacamr/dlac004.035" @default.
- W4213207675 hasPublicationYear "2022" @default.
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