Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213227562> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4213227562 abstract "Abstract Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive behavior is the type VI secretion system (T6SS). Interestingly and in contrast to non-pandemic or environmental isolates, the T6SS of the O1 El Tor clade of V. cholerae , which is responsible for the ongoing 7 th pandemic, is largely silent under standard conditions. Instead, these strains induce their full T6SS capacity only under specific conditions such as growth on chitinous surfaces (signaled through TfoX and QstR) or when the cells encounter low intracellular c-di-GMP levels (TfoY-driven). In this study, we identified a single nucleotide polymorphism (SNP) within an intergenic region of the major T6SS gene cluster of V. cholerae that determines the T6SS status of the cell. We show that SNP conversion is sufficient to induce T6SS production in numerous pandemic strains, while the converse approach renders non-pandemic/environmental V. cholerae strains T6SS-silent. We further demonstrate that SNP-dependent T6SS production occurs independently of the known T6SS regulators TfoX, QstR, and TfoY. Finally, we identify a putative promoter region adjacent to the identified SNP that is required for all forms of T6SS regulation." @default.
- W4213227562 created "2022-02-24" @default.
- W4213227562 creator A5036874273 @default.
- W4213227562 creator A5050617310 @default.
- W4213227562 creator A5052339157 @default.
- W4213227562 creator A5056548860 @default.
- W4213227562 creator A5062888228 @default.
- W4213227562 creator A5081717262 @default.
- W4213227562 date "2022-01-28" @default.
- W4213227562 modified "2023-09-30" @default.
- W4213227562 title "A single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae" @default.
- W4213227562 cites W1972038449 @default.
- W4213227562 cites W2008821578 @default.
- W4213227562 cites W2047987695 @default.
- W4213227562 cites W2065235521 @default.
- W4213227562 cites W2071424950 @default.
- W4213227562 cites W2080001285 @default.
- W4213227562 cites W2166095667 @default.
- W4213227562 cites W2171677430 @default.
- W4213227562 cites W2335882659 @default.
- W4213227562 cites W2511941815 @default.
- W4213227562 cites W2736240874 @default.
- W4213227562 cites W2783984468 @default.
- W4213227562 cites W2794120121 @default.
- W4213227562 cites W2806091710 @default.
- W4213227562 cites W2913809800 @default.
- W4213227562 cites W2921015205 @default.
- W4213227562 cites W2971788024 @default.
- W4213227562 cites W3081693055 @default.
- W4213227562 cites W3211989459 @default.
- W4213227562 cites W4206601827 @default.
- W4213227562 doi "https://doi.org/10.1101/2022.01.28.478222" @default.
- W4213227562 hasPublicationYear "2022" @default.
- W4213227562 type Work @default.
- W4213227562 citedByCount "1" @default.
- W4213227562 countsByYear W42132275622022 @default.
- W4213227562 crossrefType "posted-content" @default.
- W4213227562 hasAuthorship W4213227562A5036874273 @default.
- W4213227562 hasAuthorship W4213227562A5050617310 @default.
- W4213227562 hasAuthorship W4213227562A5052339157 @default.
- W4213227562 hasAuthorship W4213227562A5056548860 @default.
- W4213227562 hasAuthorship W4213227562A5062888228 @default.
- W4213227562 hasAuthorship W4213227562A5081717262 @default.
- W4213227562 hasBestOaLocation W42132275621 @default.
- W4213227562 hasConcept C104317684 @default.
- W4213227562 hasConcept C135763542 @default.
- W4213227562 hasConcept C153209595 @default.
- W4213227562 hasConcept C2776460866 @default.
- W4213227562 hasConcept C2778643871 @default.
- W4213227562 hasConcept C2778827730 @default.
- W4213227562 hasConcept C523546767 @default.
- W4213227562 hasConcept C54355233 @default.
- W4213227562 hasConcept C60987743 @default.
- W4213227562 hasConcept C86803240 @default.
- W4213227562 hasConcept C89423630 @default.
- W4213227562 hasConceptScore W4213227562C104317684 @default.
- W4213227562 hasConceptScore W4213227562C135763542 @default.
- W4213227562 hasConceptScore W4213227562C153209595 @default.
- W4213227562 hasConceptScore W4213227562C2776460866 @default.
- W4213227562 hasConceptScore W4213227562C2778643871 @default.
- W4213227562 hasConceptScore W4213227562C2778827730 @default.
- W4213227562 hasConceptScore W4213227562C523546767 @default.
- W4213227562 hasConceptScore W4213227562C54355233 @default.
- W4213227562 hasConceptScore W4213227562C60987743 @default.
- W4213227562 hasConceptScore W4213227562C86803240 @default.
- W4213227562 hasConceptScore W4213227562C89423630 @default.
- W4213227562 hasLocation W42132275621 @default.
- W4213227562 hasLocation W42132275622 @default.
- W4213227562 hasLocation W42132275623 @default.
- W4213227562 hasOpenAccess W4213227562 @default.
- W4213227562 hasPrimaryLocation W42132275621 @default.
- W4213227562 hasRelatedWork W12508767 @default.
- W4213227562 hasRelatedWork W12576053 @default.
- W4213227562 hasRelatedWork W13025488 @default.
- W4213227562 hasRelatedWork W15756587 @default.
- W4213227562 hasRelatedWork W23045384 @default.
- W4213227562 hasRelatedWork W23540522 @default.
- W4213227562 hasRelatedWork W27628923 @default.
- W4213227562 hasRelatedWork W28891839 @default.
- W4213227562 hasRelatedWork W3049601 @default.
- W4213227562 hasRelatedWork W32796492 @default.
- W4213227562 isParatext "false" @default.
- W4213227562 isRetracted "false" @default.
- W4213227562 workType "article" @default.