Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213230392> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4213230392 abstract "BACKGROUND: The optimal duration of dual-antiplatelet therapy and the risk-benefit ratio for long-term dual-antiplatelet therapy after coronary stenting remain poorly defined. We evaluated the impact of up to 6 versus 24 months of dual-antiplatelet therapy in a broad all-comers patient population receiving a balanced proportion of Food and Drug Administration-approved drug-eluting or bare-metal stents.METHODS AND RESULTS: We randomly assigned 2013 patients to receive bare-metal, zotarolimus-eluting, paclitaxel-eluting, or everolimus-eluting stent implantation. At 30 days, patients in each stent group were randomly allocated to receive up to 6 or 24 months of clopidogrel therapy in addition to aspirin. The primary end point was a composite of death of any cause, myocardial infarction, or cerebrovascular accident. The cumulative risk of the primary outcome at 2 years was 10.1% with 24-month dual-antiplatelet therapy compared with 10.0% with 6-month dual-antiplatelet therapy (hazard ratio, 0.98; 95% confidence interval, 0.74-1.29; P=0.91). The individual risks of death, myocardial infarction, cerebrovascular accident, or stent thrombosis did not differ between the study groups; however, there was a consistently greater risk of hemorrhage in the 24-month clopidogrel group according to all prespecified bleeding definitions, including the recently proposed Bleeding Academic Research Consortium classification.CONCLUSIONS: A regimen of 24 months of clopidogrel therapy in patients who had received a balanced mixture of drug-eluting or bare-metal stents was not significantly more effective than a 6-month clopidogrel regimen in reducing the composite of death due to any cause, myocardial infarction, or cerebrovascular accident.CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00611286. PMID: 22438530" @default.
- W4213230392 created "2022-02-24" @default.
- W4213230392 creator A5069699257 @default.
- W4213230392 date "2012-05-23" @default.
- W4213230392 modified "2023-09-26" @default.
- W4213230392 title "Faculty Opinions recommendation of Short- versus long-term duration of dual-antiplatelet therapy after coronary stenting: a randomized multicenter trial." @default.
- W4213230392 doi "https://doi.org/10.3410/f.715897902.791652832" @default.
- W4213230392 hasPublicationYear "2012" @default.
- W4213230392 type Work @default.
- W4213230392 citedByCount "0" @default.
- W4213230392 crossrefType "dataset" @default.
- W4213230392 hasAuthorship W4213230392A5069699257 @default.
- W4213230392 hasConcept C126322002 @default.
- W4213230392 hasConcept C141071460 @default.
- W4213230392 hasConcept C164705383 @default.
- W4213230392 hasConcept C168563851 @default.
- W4213230392 hasConcept C203092338 @default.
- W4213230392 hasConcept C207103383 @default.
- W4213230392 hasConcept C2777546689 @default.
- W4213230392 hasConcept C2777628954 @default.
- W4213230392 hasConcept C2777849778 @default.
- W4213230392 hasConcept C2778583881 @default.
- W4213230392 hasConcept C2780400711 @default.
- W4213230392 hasConcept C2780797203 @default.
- W4213230392 hasConcept C2781413609 @default.
- W4213230392 hasConcept C2908647359 @default.
- W4213230392 hasConcept C44249647 @default.
- W4213230392 hasConcept C500558357 @default.
- W4213230392 hasConcept C71924100 @default.
- W4213230392 hasConcept C99454951 @default.
- W4213230392 hasConceptScore W4213230392C126322002 @default.
- W4213230392 hasConceptScore W4213230392C141071460 @default.
- W4213230392 hasConceptScore W4213230392C164705383 @default.
- W4213230392 hasConceptScore W4213230392C168563851 @default.
- W4213230392 hasConceptScore W4213230392C203092338 @default.
- W4213230392 hasConceptScore W4213230392C207103383 @default.
- W4213230392 hasConceptScore W4213230392C2777546689 @default.
- W4213230392 hasConceptScore W4213230392C2777628954 @default.
- W4213230392 hasConceptScore W4213230392C2777849778 @default.
- W4213230392 hasConceptScore W4213230392C2778583881 @default.
- W4213230392 hasConceptScore W4213230392C2780400711 @default.
- W4213230392 hasConceptScore W4213230392C2780797203 @default.
- W4213230392 hasConceptScore W4213230392C2781413609 @default.
- W4213230392 hasConceptScore W4213230392C2908647359 @default.
- W4213230392 hasConceptScore W4213230392C44249647 @default.
- W4213230392 hasConceptScore W4213230392C500558357 @default.
- W4213230392 hasConceptScore W4213230392C71924100 @default.
- W4213230392 hasConceptScore W4213230392C99454951 @default.
- W4213230392 hasLocation W42132303921 @default.
- W4213230392 hasOpenAccess W4213230392 @default.
- W4213230392 hasPrimaryLocation W42132303921 @default.
- W4213230392 hasRelatedWork W12955517 @default.
- W4213230392 hasRelatedWork W2003208706 @default.
- W4213230392 hasRelatedWork W2089715561 @default.
- W4213230392 hasRelatedWork W2120465397 @default.
- W4213230392 hasRelatedWork W2399063111 @default.
- W4213230392 hasRelatedWork W2612824725 @default.
- W4213230392 hasRelatedWork W2999004991 @default.
- W4213230392 hasRelatedWork W3092868987 @default.
- W4213230392 hasRelatedWork W3210299397 @default.
- W4213230392 hasRelatedWork W2527719101 @default.
- W4213230392 isParatext "false" @default.
- W4213230392 isRetracted "false" @default.
- W4213230392 workType "dataset" @default.