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- W4213231285 abstract "Background Asthma is a chronic inflammatory airway disease characterized by episodic reversible airway obstruction. Regarding asthma pathogenesis, two eotaxin polymorphisms were found to be associated with asthma and high serum total immunoglobulin (Ig)E levels, correspondingly.Objective This study was done to explore the association between the underlying gene polymorphisms in chemokine receptor 3 (CCR3) and symptom-based clinical asthma phenotypes among the studied group.Patients and methods This was a case–control study conducted on 60 asthmatic patients with different clinical phenotypes who were compared with 100 healthy controls of matched age and sex. The included asthmatic children aged from 6 to 16 years old and were diagnosed according to the criteria of GINA 2020 by the presence of typical asthma symptoms and with confirmed variable expiratory airflow obstruction. We excluded asthmatic patients with comorbidities.Results A total of 60 asthmatic cases with different clinical phenotypes were compared with 100 healthy controls, and the outcomes showed that total serum IgE had a significant increase in asthmatic cases versus controls. There were no statistically significant differences regarding CCR3 T51C genotype or its allelic polymorphism frequency. There was no clinical significance found correlating eosinophilic percent and serum IgE and CCR3 T51C gene polymorphism in both asthmatic cases and control. There was no statistical significance correlating eosinophilic count, eosinophilic percent, and total serum IgE with different clinical asthma phenotypes.Conclusion Total serum IgE was demonstrated to be significantly increased among asthmatic cases; however, there were no statistically significant differences regarding CCR3 T51C genotype or its allelic polymorphism frequency. Eosinophilic percent and serum IgE and CCR3 T51C gene polymorphism seemed to be comparable among asthmatic cases and controls. Moreover, no significant correlation was detected associating eosinophilic count, eosinophilic percent, and total serum IgE with different clinical asthma phenotypes." @default.
- W4213231285 created "2022-02-24" @default.
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- W4213231285 date "2021-01-01" @default.
- W4213231285 modified "2023-10-06" @default.
- W4213231285 title "Association between the chemokine receptor 3 gene polymorphism and clinical asthma phenotypes among Egyptian asthmatic children" @default.
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- W4213231285 doi "https://doi.org/10.4103/1687-9945.337835" @default.
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