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• W4213231823 abstract "<sec> <title>BACKGROUND</title> Topic modeling of patient medication reviews (PMRs) of erectile dysfunction (ED) drugs can help identify the patient preferences regarding ED treatment options. The identification of a set of topics important to the patient from SNS drug reviews would inform the design of patient-centered medication counseling. </sec> <sec> <title>OBJECTIVE</title> This study aimed 1) to identify the distinctive topics from PMRs unique to tadalafil versus sildenafil; 2) to determine if the primary topics are distributed differently for each drug and for each patient characteristics (age and time on ED drug therapy); and 3) to test if the primary topics affect satisfaction with ED drug therapy controlling for the patient characteristics. </sec> <sec> <title>METHODS</title> Data were collected from the PMRs of sildenafil and tadalafil posted prior to July 1, 2019 on WebMD and Ask a Patient. The Latent Dirichlet allocation (LDA) method of natural language processing (NLP) was used to identify five distinctive topics from the PMRs on each drug. Analysis of variance (ANOVA) and two sample t-test were conducted to compare the topic distribution and test whether patient satisfaction varies with the primary topics, age, and time on medication for each ED drugs. Statistical significance was tested at an alpha of .05. </sec> <sec> <title>RESULTS</title> The PMRs of sildenafil (N = 463) had two topics on treatment benefit and one each on medication safety, marketing claim, and treatment comparison, while the PMRs on tadalafil (N = 919) had two on medication safety and one each on the remaining subjects. Sildenafil’s reviewers quite frequently (94/463, 20.4%) mentioned erection sustainability as their primary topic, whereas tadalafil’s reviewers were more concerned about severe medication safety. Those who mentioned erection sustainability as their primary topic were quite satisfied with their treatment as opposed to those for whom the primary topic was severe medication safety (3.85 vs. 2.44). The discovered topics reflected the marketing claims of “Blue Magic” and “Amber Romance” respective of each drug. The topic of blue magic was preferred among younger patients while the topic of amber romance topic was preferred among older patients. The topic “Alternative Choices” which appeared for both the ED pills reflected the patient interest in the comparative effectiveness and prices outside the drug labeling information. </sec> <sec> <title>CONCLUSIONS</title> The topics identified from patient medication reviews of ED drugs reflect drug labeling information, marketing claims, and comparative alternative choices facing patients in real world practices. Topic modeling of natural language expressed in patient medication reviews can identify patient medication concerns, which are crucial for patient-centered prescribing and medication counseling. </sec> <sec> <title>CLINICALTRIAL</title> <p /> </sec>" @default.
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• W4213231823 date "2021-08-06" @default.
• W4213231823 modified "2023-09-28" @default.
• W4213231823 title "Applying Topic Modeling Approach to Patient Medication Reviews of Erectile Dysfunction Drugs: Sildenafil versus Tadalafil (Preprint)" @default.
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• W4213231823 doi "https://doi.org/10.2196/preprints.32689" @default.
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