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- W4213239603 endingPage "417" @default.
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- W4213239603 abstract "Microbial pathogens that cause severe infections and are resistant to drugs are simultaneously becoming more active. This urgently calls for novel effective antibiotics. Organisms from extreme environments are known to synthesize novel bioprospecting molecules for biomedical applications due to their peculiar characteristics of growth and physiological conditions. Antimicrobial developments from hypersaline environments, such as lagoons, estuaries, and salterns, accommodate several halophilic microbes. Salinity is a distinctive environmental factor that continuously promotes the metabolic adaptation and flexibility of halophilic microbes for their survival at minimum nutritional requirements. A genetic adaptation to extreme solar radiation, ionic strength, and desiccation makes them promising candidates for drug discovery. More microbiota identified via sequencing and 'omics' approaches signify the hypersaline environments where compounds are produced. Microbial genera such as Bacillus, Actinobacteria, Halorubrum and Aspergillus are producing a substantial number of antimicrobial compounds. Several strategies were applied for producing novel antimicrobials from halophiles including a consortia approach. Promising results indicate that halophilic microbes can be utilised as prolific sources of bioactive metabolites with pharmaceutical potentialto expand natural product research towards diverse phylogenetic microbial groups which inhabit salterns. The present study reviews interesting antimicrobial compounds retrieved from microbial sources of various saltern environments, with a discussion of their potency in providing novel drugs against clinically drug-resistant microbes." @default.
- W4213239603 created "2022-02-24" @default.
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- W4213239603 creator A5077603986 @default.
- W4213239603 date "2022-02-11" @default.
- W4213239603 modified "2023-10-18" @default.
- W4213239603 title "Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens" @default.
- W4213239603 cites W1828521031 @default.
- W4213239603 cites W1970935314 @default.
- W4213239603 cites W1973076912 @default.
- W4213239603 cites W1981194760 @default.
- W4213239603 cites W1987481951 @default.
- W4213239603 cites W2002498973 @default.
- W4213239603 cites W2003347403 @default.
- W4213239603 cites W2009902684 @default.
- W4213239603 cites W2011934361 @default.
- W4213239603 cites W2013532536 @default.
- W4213239603 cites W2015490812 @default.
- W4213239603 cites W2019704024 @default.
- W4213239603 cites W2029971700 @default.
- W4213239603 cites W2031306746 @default.
- W4213239603 cites W2034149228 @default.
- W4213239603 cites W2037115519 @default.
- W4213239603 cites W2044066756 @default.
- W4213239603 cites W2055480953 @default.
- W4213239603 cites W2059956975 @default.
- W4213239603 cites W2060590186 @default.
- W4213239603 cites W2077029976 @default.
- W4213239603 cites W2079632899 @default.
- W4213239603 cites W2088458082 @default.
- W4213239603 cites W2089642323 @default.
- W4213239603 cites W2093570910 @default.
- W4213239603 cites W2095175812 @default.
- W4213239603 cites W2123145497 @default.
- W4213239603 cites W2168320862 @default.
- W4213239603 cites W2233049449 @default.
- W4213239603 cites W2288711498 @default.
- W4213239603 cites W2290802362 @default.
- W4213239603 cites W2291668739 @default.
- W4213239603 cites W2303393657 @default.
- W4213239603 cites W2340719511 @default.
- W4213239603 cites W2341065631 @default.
- W4213239603 cites W2461023304 @default.
- W4213239603 cites W2497281644 @default.
- W4213239603 cites W2521590920 @default.
- W4213239603 cites W2561517554 @default.
- W4213239603 cites W2561689319 @default.
- W4213239603 cites W2605052041 @default.
- W4213239603 cites W2605129970 @default.
- W4213239603 cites W2619711360 @default.
- W4213239603 cites W2620248952 @default.
- W4213239603 cites W2737416438 @default.
- W4213239603 cites W2739882170 @default.
- W4213239603 cites W2741000571 @default.
- W4213239603 cites W2747870068 @default.
- W4213239603 cites W2752580790 @default.
- W4213239603 cites W2755440815 @default.
- W4213239603 cites W2770230296 @default.
- W4213239603 cites W2770475264 @default.
- W4213239603 cites W2770986455 @default.
- W4213239603 cites W2771898126 @default.
- W4213239603 cites W2784175495 @default.
- W4213239603 cites W2793115466 @default.
- W4213239603 cites W2795658902 @default.
- W4213239603 cites W2798150355 @default.
- W4213239603 cites W2799524357 @default.
- W4213239603 cites W2802113376 @default.
- W4213239603 cites W2803395445 @default.
- W4213239603 cites W2805718686 @default.
- W4213239603 cites W2807425422 @default.
- W4213239603 cites W2810554058 @default.
- W4213239603 cites W2882524933 @default.
- W4213239603 cites W2884617409 @default.
- W4213239603 cites W2889894321 @default.
- W4213239603 cites W2890294065 @default.
- W4213239603 cites W2893681743 @default.
- W4213239603 cites W2895764046 @default.
- W4213239603 cites W2896130185 @default.
- W4213239603 cites W2899797213 @default.
- W4213239603 cites W2903143844 @default.
- W4213239603 cites W2903347362 @default.
- W4213239603 cites W2903584501 @default.
- W4213239603 cites W2907531852 @default.
- W4213239603 cites W2908184655 @default.
- W4213239603 cites W2912868485 @default.
- W4213239603 cites W2922287530 @default.
- W4213239603 cites W2941288428 @default.
- W4213239603 cites W2944662322 @default.
- W4213239603 cites W2949667527 @default.
- W4213239603 cites W2949715642 @default.
- W4213239603 cites W2950079489 @default.
- W4213239603 cites W2955138947 @default.