FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213249761> ?p ?o ?g. }

• W4213249761 endingPage "177" @default.
• W4213249761 startingPage "165" @default.
• W4213249761 abstract "Leishmaniasis is the second most important neglected tropical parasitic disease after malaria. This disease is distributed worldwide and can be present in a variety of clinical forms, depending on the parasite species and host's genetic background. As chemotherapy is the only effective weapon whose effectiveness is limited by the frequent appearance of drug resistance and therapeutic failure, new therapeutic strategies are required. To better understand the factors that contribute to therapeutic failure and drug resistance in leishmaniasis, we studied the transcriptomic changes in host THP-1 cells after infection with clinical Leishmania infantum isolates with different susceptibilities to antileishmanial drugs by RNA-seq. Analysis of the differentially expressed genes (DEGs) in infected host cells revealed variations in DEG numbers in the THP-1-infected cells depending on the Leishmania line. A key conclusion of this study is that the modulation of host cells is Leishmania line dependent. Gene ontology enrichment analyses of DEGs indicated that certain biological processes were modulated in the infected host cells, specifically related to cellular metabolism, immune response, defense response, signaling pathways, and cell proliferation and apoptosis. Furthermore, this study provides new potential therapeutic markers and insights into the THP-1 host transcriptomic changes that occur after late infection with drug-resistant L. infantum clinical isolates." @default.
• W4213249761 created "2022-02-24" @default.
• W4213249761 creator A5009167815 @default.
• W4213249761 creator A5064828852 @default.
• W4213249761 creator A5071726707 @default.
• W4213249761 creator A5077188686 @default.
• W4213249761 date "2022-03-01" @default.
• W4213249761 modified "2023-09-26" @default.
• W4213249761 title "New Insights on Drug-Resistant Clinical Isolates of <i>Leishmania infantum</i>-Infected Human Macrophages as Determined by Comparative Transcriptome Analyses" @default.
• W4213249761 cites W148731515 @default.
• W4213249761 cites W1870991025 @default.
• W4213249761 cites W1929137618 @default.
• W4213249761 cites W1936936560 @default.
• W4213249761 cites W1967535111 @default.
• W4213249761 cites W1969449483 @default.
• W4213249761 cites W1990304428 @default.
• W4213249761 cites W1992617948 @default.
• W4213249761 cites W2007483233 @default.
• W4213249761 cites W2012431429 @default.
• W4213249761 cites W2031889260 @default.
• W4213249761 cites W2035618305 @default.
• W4213249761 cites W2055956456 @default.
• W4213249761 cites W2059553283 @default.
• W4213249761 cites W2060100629 @default.
• W4213249761 cites W2068928893 @default.
• W4213249761 cites W2071271349 @default.
• W4213249761 cites W2094161235 @default.
• W4213249761 cites W2099556150 @default.
• W4213249761 cites W2101874338 @default.
• W4213249761 cites W2102278945 @default.
• W4213249761 cites W2103740237 @default.
• W4213249761 cites W2107018762 @default.
• W4213249761 cites W2107277218 @default.
• W4213249761 cites W2108244474 @default.
• W4213249761 cites W2111196960 @default.
• W4213249761 cites W2125777641 @default.
• W4213249761 cites W2146512944 @default.
• W4213249761 cites W2146955021 @default.
• W4213249761 cites W2147175809 @default.
• W4213249761 cites W2148596215 @default.
• W4213249761 cites W2151470016 @default.
• W4213249761 cites W2151770702 @default.
• W4213249761 cites W2156382913 @default.
• W4213249761 cites W2157399331 @default.
• W4213249761 cites W2158541290 @default.
• W4213249761 cites W2158670312 @default.
• W4213249761 cites W2164502478 @default.
• W4213249761 cites W2164511223 @default.
• W4213249761 cites W2170906690 @default.
• W4213249761 cites W2218359875 @default.
• W4213249761 cites W2350123421 @default.
• W4213249761 cites W2384133405 @default.
• W4213249761 cites W2486376398 @default.
• W4213249761 cites W2775643792 @default.
• W4213249761 cites W2790291758 @default.
• W4213249761 cites W2803195495 @default.
• W4213249761 cites W2907823975 @default.
• W4213249761 cites W2967921201 @default.
• W4213249761 cites W2984508410 @default.
• W4213249761 cites W2987997424 @default.
• W4213249761 cites W3026040460 @default.
• W4213249761 cites W590350978 @default.
• W4213249761 cites W790205961 @default.
• W4213249761 doi "https://doi.org/10.1089/omi.2021.0185" @default.
• W4213249761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35172107" @default.
• W4213249761 hasPublicationYear "2022" @default.
• W4213249761 type Work @default.
• W4213249761 citedByCount "3" @default.
• W4213249761 countsByYear W42132497612022 @default.
• W4213249761 countsByYear W42132497612023 @default.
• W4213249761 crossrefType "journal-article" @default.
• W4213249761 hasAuthorship W4213249761A5009167815 @default.
• W4213249761 hasAuthorship W4213249761A5064828852 @default.
• W4213249761 hasAuthorship W4213249761A5071726707 @default.
• W4213249761 hasAuthorship W4213249761A5077188686 @default.
• W4213249761 hasConcept C104317684 @default.
• W4213249761 hasConcept C114851261 @default.
• W4213249761 hasConcept C136764020 @default.
• W4213249761 hasConcept C150194340 @default.
• W4213249761 hasConcept C159047783 @default.
• W4213249761 hasConcept C162317418 @default.
• W4213249761 hasConcept C203014093 @default.
• W4213249761 hasConcept C2776555147 @default.
• W4213249761 hasConcept C2778689377 @default.
• W4213249761 hasConcept C2780035454 @default.
• W4213249761 hasConcept C2781092759 @default.
• W4213249761 hasConcept C2781257258 @default.
• W4213249761 hasConcept C41008148 @default.
• W4213249761 hasConcept C54355233 @default.
• W4213249761 hasConcept C70721500 @default.
• W4213249761 hasConcept C71928629 @default.
• W4213249761 hasConcept C86803240 @default.
• W4213249761 hasConcept C8891405 @default.
• W4213249761 hasConcept C89423630 @default.
• W4213249761 hasConcept C98274493 @default.
• W4213249761 hasConceptScore W4213249761C104317684 @default.
• W4213249761 hasConceptScore W4213249761C114851261 @default.
• W4213249761 hasConceptScore W4213249761C136764020 @default.

• next