FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213261579> ?p ?o ?g. }

• W4213261579 endingPage "733" @default.
• W4213261579 startingPage "733" @default.
• W4213261579 abstract "The purpose of our study is to investigate early cellular, molecular, morphological and behavioral changes in humanized amyloid-beta-knock-in (hAbKI) mice. Using seven-month-old homozygous hAbKI mice, we studied behavioral phenotype parameters, including spatial learning and memory (Morris Water Maze), locomotor activity (open field), working memory (Y-maze) and motor coordination (rotarod); mRNA abundance, protein levels, soluble amyloid-beta 40 and 42 levels and regional immunoreactivities of key markers of mitochondrial dynamics, mitochondrial biogenesis, synaptic health, mitophagy and autophagy; mitochondrial function and using transmission electron microscopy & Golgi-Cox staining, we assessed mitochondrial morphology and dendritic spines. Our extensive behavioral analysis revealed that seven-month-old hAbKI mice showed impairments in motor coordination, reduced locomotor and exploration activities, impairments in working memory and spatial learning and memory. Our mRNA and protein analyses revealed the increased expression of mitochondrial-fission genes and reduced expression of mitochondrial-fusion, mitochondrial-biogenesis, synaptic, autophagy and mitophagy genes in seven-month-old hAbKI mice. An immunofluorescence analysis revealed altered immunoreactivities and agreed with the immunoblot results. Transmission-electron-microscopy data revealed increased mitochondrial fragmentation and reduced mitochondrial length in both hippocampal and cortical tissues of seven-month-old hAbKI mice and mitochondrial function defective. A Golgi-Cox-staining analysis revealed reduced dendritic spines in both cerebral cortices and hippocampi of hAbKI mice. Soluble amyloid-beta (1-40 and 1-42) were detected in three-month-old hAbKI mice and progressively increased in seven-month-old mice. These observations suggest that the human amyloid-beta peptide is sufficient to cause behavioral, mitochondrial, synaptic and ultrastructural changes in seven-month-old hAbKI mice. Our study findings also suggest that hAbKI mice might serve as a model for preclinical studies of preventive therapies." @default.
• W4213261579 created "2022-02-24" @default.
• W4213261579 creator A5032668464 @default.
• W4213261579 creator A5042058638 @default.
• W4213261579 creator A5052681595 @default.
• W4213261579 creator A5062197554 @default.
• W4213261579 creator A5065828728 @default.
• W4213261579 creator A5067956284 @default.
• W4213261579 creator A5082470170 @default.
• W4213261579 creator A5084673116 @default.
• W4213261579 creator A5089880857 @default.
• W4213261579 date "2022-02-19" @default.
• W4213261579 modified "2023-09-26" @default.
• W4213261579 title "Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer’s Disease" @default.
• W4213261579 cites W1602771322 @default.
• W4213261579 cites W1968257316 @default.
• W4213261579 cites W1993025871 @default.
• W4213261579 cites W2007047564 @default.
• W4213261579 cites W2009012892 @default.
• W4213261579 cites W2027009370 @default.
• W4213261579 cites W2082429191 @default.
• W4213261579 cites W2116485041 @default.
• W4213261579 cites W2119808485 @default.
• W4213261579 cites W2124955411 @default.
• W4213261579 cites W21428969 @default.
• W4213261579 cites W2146282250 @default.
• W4213261579 cites W2163859059 @default.
• W4213261579 cites W2168334242 @default.
• W4213261579 cites W2169152986 @default.
• W4213261579 cites W2418740217 @default.
• W4213261579 cites W2460285625 @default.
• W4213261579 cites W2519570594 @default.
• W4213261579 cites W2527422074 @default.
• W4213261579 cites W2761011647 @default.
• W4213261579 cites W2779463443 @default.
• W4213261579 cites W2789405288 @default.
• W4213261579 cites W2790798430 @default.
• W4213261579 cites W2802911313 @default.
• W4213261579 cites W2889808182 @default.
• W4213261579 cites W2891411797 @default.
• W4213261579 cites W2944325086 @default.
• W4213261579 cites W2965717703 @default.
• W4213261579 cites W3029234273 @default.
• W4213261579 cites W3034246445 @default.
• W4213261579 cites W3091354748 @default.
• W4213261579 cites W3097560931 @default.
• W4213261579 cites W3107201314 @default.
• W4213261579 cites W3124752519 @default.
• W4213261579 cites W3125441563 @default.
• W4213261579 cites W3130473940 @default.
• W4213261579 cites W3137306540 @default.
• W4213261579 cites W3152722365 @default.
• W4213261579 cites W3156469684 @default.
• W4213261579 cites W3180069668 @default.
• W4213261579 cites W3197175151 @default.
• W4213261579 cites W3200254049 @default.
• W4213261579 cites W3213231179 @default.
• W4213261579 cites W3215571011 @default.
• W4213261579 cites W4235875658 @default.
• W4213261579 doi "https://doi.org/10.3390/cells11040733" @default.
• W4213261579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35203382" @default.
• W4213261579 hasPublicationYear "2022" @default.
• W4213261579 type Work @default.
• W4213261579 citedByCount "8" @default.
• W4213261579 countsByYear W42132615792022 @default.
• W4213261579 countsByYear W42132615792023 @default.
• W4213261579 crossrefType "journal-article" @default.
• W4213261579 hasAuthorship W4213261579A5032668464 @default.
• W4213261579 hasAuthorship W4213261579A5042058638 @default.
• W4213261579 hasAuthorship W4213261579A5052681595 @default.
• W4213261579 hasAuthorship W4213261579A5062197554 @default.
• W4213261579 hasAuthorship W4213261579A5065828728 @default.
• W4213261579 hasAuthorship W4213261579A5067956284 @default.
• W4213261579 hasAuthorship W4213261579A5082470170 @default.
• W4213261579 hasAuthorship W4213261579A5084673116 @default.
• W4213261579 hasAuthorship W4213261579A5089880857 @default.
• W4213261579 hasBestOaLocation W42132615791 @default.
• W4213261579 hasConcept C142724271 @default.
• W4213261579 hasConcept C148762608 @default.
• W4213261579 hasConcept C169760540 @default.
• W4213261579 hasConcept C174884520 @default.
• W4213261579 hasConcept C17619807 @default.
• W4213261579 hasConcept C190283241 @default.
• W4213261579 hasConcept C203522944 @default.
• W4213261579 hasConcept C2776156579 @default.
• W4213261579 hasConcept C2777229759 @default.
• W4213261579 hasConcept C2779134260 @default.
• W4213261579 hasConcept C2779281246 @default.
• W4213261579 hasConcept C2779324830 @default.
• W4213261579 hasConcept C2781161787 @default.
• W4213261579 hasConcept C28859421 @default.
• W4213261579 hasConcept C31705614 @default.
• W4213261579 hasConcept C44752575 @default.
• W4213261579 hasConcept C502032728 @default.
• W4213261579 hasConcept C55493867 @default.
• W4213261579 hasConcept C71924100 @default.
• W4213261579 hasConcept C86803240 @default.
• W4213261579 hasConcept C95444343 @default.

• next