Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213266411> ?p ?o ?g. }
- W4213266411 endingPage "191" @default.
- W4213266411 startingPage "177" @default.
- W4213266411 abstract "Abstract P2X receptors are trimeric nonselective cation channels gated by ATP. They assemble from seven distinct subunit isoforms as either homo- or heteromeric complexes and contain three extracellularly located binding sites for ATP. P2X receptors are expressed in nearly all tissues and are there involved in physiological processes like synaptic transmission, pain, and inflammation. Thus, they are a challenging pharmacological target. The determination of crystal and cryo-EM structures of several isoforms in the last decade in closed, open, and desensitized states has provided a firm basis for interpreting the huge amount of functional and biochemical data. Electrophysiological characterization in conjugation with optical approaches has generated significant insights into structure–function relationships of P2X receptors. This review focuses on novel optical and related approaches to better understand the conformational changes underlying the activation of these receptors." @default.
- W4213266411 created "2022-02-24" @default.
- W4213266411 creator A5013747364 @default.
- W4213266411 creator A5084851930 @default.
- W4213266411 date "2022-02-21" @default.
- W4213266411 modified "2023-10-18" @default.
- W4213266411 title "Enlightening activation gating in P2X receptors" @default.
- W4213266411 cites W1019883783 @default.
- W4213266411 cites W1149453948 @default.
- W4213266411 cites W1524412093 @default.
- W4213266411 cites W1546894681 @default.
- W4213266411 cites W1608870321 @default.
- W4213266411 cites W1775244163 @default.
- W4213266411 cites W1830561018 @default.
- W4213266411 cites W1837514060 @default.
- W4213266411 cites W1852253371 @default.
- W4213266411 cites W1914891471 @default.
- W4213266411 cites W1964349405 @default.
- W4213266411 cites W1966338830 @default.
- W4213266411 cites W1970597425 @default.
- W4213266411 cites W1973638721 @default.
- W4213266411 cites W1979070806 @default.
- W4213266411 cites W1980221458 @default.
- W4213266411 cites W1982014643 @default.
- W4213266411 cites W1984336779 @default.
- W4213266411 cites W1990539640 @default.
- W4213266411 cites W1990891308 @default.
- W4213266411 cites W1992905004 @default.
- W4213266411 cites W1996555147 @default.
- W4213266411 cites W1997511216 @default.
- W4213266411 cites W2000163444 @default.
- W4213266411 cites W2000749144 @default.
- W4213266411 cites W2004066544 @default.
- W4213266411 cites W2004111769 @default.
- W4213266411 cites W2007046005 @default.
- W4213266411 cites W2007458026 @default.
- W4213266411 cites W2008176274 @default.
- W4213266411 cites W2009667219 @default.
- W4213266411 cites W2014506974 @default.
- W4213266411 cites W2015426350 @default.
- W4213266411 cites W2018763173 @default.
- W4213266411 cites W2020372966 @default.
- W4213266411 cites W2021444357 @default.
- W4213266411 cites W2021815653 @default.
- W4213266411 cites W2024574895 @default.
- W4213266411 cites W2025150024 @default.
- W4213266411 cites W2026406183 @default.
- W4213266411 cites W2032038036 @default.
- W4213266411 cites W2032252553 @default.
- W4213266411 cites W2040562193 @default.
- W4213266411 cites W2041181551 @default.
- W4213266411 cites W2042463836 @default.
- W4213266411 cites W2042954879 @default.
- W4213266411 cites W2044194617 @default.
- W4213266411 cites W2046803215 @default.
- W4213266411 cites W2048201868 @default.
- W4213266411 cites W2049685941 @default.
- W4213266411 cites W2050786281 @default.
- W4213266411 cites W2051057929 @default.
- W4213266411 cites W2051970897 @default.
- W4213266411 cites W2056544336 @default.
- W4213266411 cites W2060641239 @default.
- W4213266411 cites W2063339881 @default.
- W4213266411 cites W2064734599 @default.
- W4213266411 cites W2066573557 @default.
- W4213266411 cites W2066784771 @default.
- W4213266411 cites W2066832022 @default.
- W4213266411 cites W2067256827 @default.
- W4213266411 cites W2069802291 @default.
- W4213266411 cites W2070093918 @default.
- W4213266411 cites W2077433372 @default.
- W4213266411 cites W2078323484 @default.
- W4213266411 cites W2080264262 @default.
- W4213266411 cites W2080454718 @default.
- W4213266411 cites W2080792996 @default.
- W4213266411 cites W2081223551 @default.
- W4213266411 cites W2081784613 @default.
- W4213266411 cites W2087209077 @default.
- W4213266411 cites W2087823674 @default.
- W4213266411 cites W2088831056 @default.
- W4213266411 cites W2094517427 @default.
- W4213266411 cites W2095795382 @default.
- W4213266411 cites W2098354615 @default.
- W4213266411 cites W2099163813 @default.
- W4213266411 cites W2100031955 @default.
- W4213266411 cites W2100447139 @default.
- W4213266411 cites W2100769672 @default.
- W4213266411 cites W2105711740 @default.
- W4213266411 cites W2106670341 @default.
- W4213266411 cites W2111574871 @default.
- W4213266411 cites W2125846751 @default.
- W4213266411 cites W2128172592 @default.
- W4213266411 cites W2129411418 @default.
- W4213266411 cites W2131653841 @default.
- W4213266411 cites W2136134177 @default.
- W4213266411 cites W2139852988 @default.
- W4213266411 cites W2142844453 @default.
- W4213266411 cites W2142965147 @default.