FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213266608> ?p ?o ?g. }

• W4213266608 endingPage "120410" @default.
• W4213266608 startingPage "120410" @default.
• W4213266608 abstract "Liver cirrhosis is the result of a vicious cycle of both chronic oxidative stress and inflammation. NADPH oxidase-4 (NOX4) and its companion, NOD-like receptor protein 3 (NLRP3) inflammasome, are emerging as therapeutic targets of liver fibrosis.Baicalin (BA), a natural flavone, has been investigated for its therapeutic potential against cirrhosis induced by thioacetamide (TAA) (200 mg/kg, twice/week) for 12 weeks in Sprague-Dawley rats. Two doses of BA were administered (25 and 75 mg/kg/day, orally, a week after TAA was stopped and continued for 4 weeks).BA was able to reduce fibrosis visualized by Masson trichrome and immunohistochemical staining of the hepatic α-smooth muscle actin (α-SMA) and transforming growth factor-β1. Moreover, BA was able to ameliorate inflammation by reducing hepatic NLRP3 inflammasome subunits, NLRP3 and caspase-1, both parts of the complex responsible for the activation of different interleukins (IL), measured as IL-1β. In addition, BA was able to reduce hepatic nuclear factor kappa B (NF-κB)-driven inflammation through IL-6. BA targeted inflammation through its anti-oxidant ability evidenced by the enhancement of the hepatic superoxide dismutase (SOD) and reduced glutathione (GSH) activity and level, respectively, and the reduction of both hepatic malondialdehyde (MDA) and nitric oxide (NOx) contents. Treatment with BA significantly decreased TAA-induced elevation in hepatic NOX4, a key enzyme for reactive oxygen species (ROS) generation, as well as, inducible nitric oxide synthase (iNOS).therefore, the study could conclude, the anti-fibrotic effect of BA through TGF- β1/NOX4/NF-κB/NLRP3 pathway, exerting both anti-inflammatory and anti-oxidant effects." @default.
• W4213266608 created "2022-02-24" @default.
• W4213266608 creator A5032326805 @default.
• W4213266608 creator A5042274232 @default.
• W4213266608 creator A5053351285 @default.
• W4213266608 date "2022-04-01" @default.
• W4213266608 modified "2023-10-18" @default.
• W4213266608 title "Hepatoprotective effect of Baicalin against thioacetamide-induced cirrhosis in rats: Targeting NOX4/NF-κB/NLRP3 inflammasome signaling pathways" @default.
• W4213266608 cites W2002586148 @default.
• W4213266608 cites W2012961360 @default.
• W4213266608 cites W2032465754 @default.
• W4213266608 cites W2056376819 @default.
• W4213266608 cites W2068084277 @default.
• W4213266608 cites W2135919238 @default.
• W4213266608 cites W2137052325 @default.
• W4213266608 cites W2180729846 @default.
• W4213266608 cites W2334829355 @default.
• W4213266608 cites W2476901670 @default.
• W4213266608 cites W2481644027 @default.
• W4213266608 cites W2728112094 @default.
• W4213266608 cites W2738369728 @default.
• W4213266608 cites W2745854656 @default.
• W4213266608 cites W2746111758 @default.
• W4213266608 cites W2750515859 @default.
• W4213266608 cites W2765560649 @default.
• W4213266608 cites W2777958821 @default.
• W4213266608 cites W2944433963 @default.
• W4213266608 cites W2954782052 @default.
• W4213266608 cites W3010087588 @default.
• W4213266608 cites W3082649564 @default.
• W4213266608 cites W3094517534 @default.
• W4213266608 cites W3109990765 @default.
• W4213266608 cites W3118374654 @default.
• W4213266608 cites W3124528306 @default.
• W4213266608 cites W3131215121 @default.
• W4213266608 cites W3149058386 @default.
• W4213266608 cites W3162919364 @default.
• W4213266608 cites W3175103604 @default.
• W4213266608 cites W3205438088 @default.
• W4213266608 cites W3213306957 @default.
• W4213266608 cites W3217343291 @default.
• W4213266608 cites W4200434349 @default.
• W4213266608 cites W4205572061 @default.
• W4213266608 doi "https://doi.org/10.1016/j.lfs.2022.120410" @default.
• W4213266608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35182557" @default.
• W4213266608 hasPublicationYear "2022" @default.
• W4213266608 type Work @default.
• W4213266608 citedByCount "14" @default.
• W4213266608 countsByYear W42132666082022 @default.
• W4213266608 countsByYear W42132666082023 @default.
• W4213266608 crossrefType "journal-article" @default.
• W4213266608 hasAuthorship W4213266608A5032326805 @default.
• W4213266608 hasAuthorship W4213266608A5042274232 @default.
• W4213266608 hasAuthorship W4213266608A5053351285 @default.
• W4213266608 hasConcept C126322002 @default.
• W4213266608 hasConcept C134018914 @default.
• W4213266608 hasConcept C185592680 @default.
• W4213266608 hasConcept C2775838275 @default.
• W4213266608 hasConcept C2776151105 @default.
• W4213266608 hasConcept C2776914184 @default.
• W4213266608 hasConcept C2777209026 @default.
• W4213266608 hasConcept C2777214474 @default.
• W4213266608 hasConcept C2777622882 @default.
• W4213266608 hasConcept C2778401633 @default.
• W4213266608 hasConcept C2779385521 @default.
• W4213266608 hasConcept C2779719074 @default.
• W4213266608 hasConcept C2779765511 @default.
• W4213266608 hasConcept C2781057625 @default.
• W4213266608 hasConcept C2993667909 @default.
• W4213266608 hasConcept C519581460 @default.
• W4213266608 hasConcept C55493867 @default.
• W4213266608 hasConcept C71924100 @default.
• W4213266608 hasConcept C98274493 @default.
• W4213266608 hasConceptScore W4213266608C126322002 @default.
• W4213266608 hasConceptScore W4213266608C134018914 @default.
• W4213266608 hasConceptScore W4213266608C185592680 @default.
• W4213266608 hasConceptScore W4213266608C2775838275 @default.
• W4213266608 hasConceptScore W4213266608C2776151105 @default.
• W4213266608 hasConceptScore W4213266608C2776914184 @default.
• W4213266608 hasConceptScore W4213266608C2777209026 @default.
• W4213266608 hasConceptScore W4213266608C2777214474 @default.
• W4213266608 hasConceptScore W4213266608C2777622882 @default.
• W4213266608 hasConceptScore W4213266608C2778401633 @default.
• W4213266608 hasConceptScore W4213266608C2779385521 @default.
• W4213266608 hasConceptScore W4213266608C2779719074 @default.
• W4213266608 hasConceptScore W4213266608C2779765511 @default.
• W4213266608 hasConceptScore W4213266608C2781057625 @default.
• W4213266608 hasConceptScore W4213266608C2993667909 @default.
• W4213266608 hasConceptScore W4213266608C519581460 @default.
• W4213266608 hasConceptScore W4213266608C55493867 @default.
• W4213266608 hasConceptScore W4213266608C71924100 @default.
• W4213266608 hasConceptScore W4213266608C98274493 @default.
• W4213266608 hasLocation W42132666081 @default.
• W4213266608 hasLocation W42132666082 @default.
• W4213266608 hasOpenAccess W4213266608 @default.
• W4213266608 hasPrimaryLocation W42132666081 @default.
• W4213266608 hasRelatedWork W1990447376 @default.
• W4213266608 hasRelatedWork W2014181690 @default.

• next