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- W4213282410 abstract "Nucleosome disruption and replacement are crucial activities that maintain epigenomes, but these highly dynamic processes have been difficult to study. Here, we describe a direct method for measuring nucleosome turnover dynamics genome-wide. We found that nucleosome turnover is most rapid over active gene bodies, epigenetic regulatory elements, and replication origins in Drosophila cells. Nucleosomes turn over faster at sites for trithorax-group than polycomb-group protein binding, suggesting that nucleosome turnover differences underlie their opposing activities and challenging models for epigenetic inheritance that rely on stability of histone marks. Our results establish a general strategy for studying nucleosome dynamics and uncover nucleosome turnover differences across the genome that are likely to have functional importance for epigenome maintenance, gene regulation, and control of DNA replication. PMID: 20508129 Funding information This work was supported by: NIDA NIH HHS, United States Grant ID: R21 DA025758-02 NIDA NIH HHS, United States Grant ID: 1R21DA025758 NIGMS NIH HHS, United States Grant ID: 1F32GM083449 NIDA NIH HHS, United States Grant ID: R21 DA025758 Howard Hughes Medical Institute, United States NIGMS NIH HHS, United States Grant ID: F32 GM083449 NIGMS NIH HHS, United States Grant ID: F32 GM083449-03 More Less keyboard_arrow_down" @default.
- W4213282410 created "2022-02-24" @default.
- W4213282410 creator A5049450448 @default.
- W4213282410 date "2010-06-18" @default.
- W4213282410 modified "2023-09-30" @default.
- W4213282410 title "Faculty Opinions recommendation of Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones." @default.
- W4213282410 doi "https://doi.org/10.3410/f.3548982.3352058" @default.
- W4213282410 hasPublicationYear "2010" @default.
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