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• W4213293403 startingPage "717S" @default.
• W4213293403 abstract "This review evaluates scientific data associated with the possibility that trans fatty acids compromise fetal and infant early development. Concerns have been triggered by research that has heightened our awareness of the importance of n3 and n6 fatty acids; shown that trans fatty acids inhibit 6 desaturation of linoleic acid; identified trans fatty acid isomers in fetal, infant, and maternal tissues; and reported an inverse association between the trans fatty acid content of tissue lipids and measures of growth and development. Animal studies provide little evidence that trans fatty acids influence growth, reproduction, or gross aspects of fetal development. However, these models may not have been appropriate for addressing all the subtle effects that influence development of human infant retinal, neural, or brain function. Human studies are hampered by the complexity of the interrelations among nutritional, genetic, and environmental factors and by ethical considerations that constrain the research design. Existing data have not established a causal relation between trans fatty acid intake and early development. Conclusions cannot be drawn from the possible association found between trans fatty acid exposure and lower n3 and n6 long-chain polyunsaturated fatty acids and growth because of confounding factors. Few studies addressed the question of whether trans fatty acids adversely affect human fetal growth. One study reported a correlation between the trans fatty acid content of plasma and birth weight of preterm infants and one study reported a relation between preterm births and the trans fatty acid content of maternal plasma. Limited associative data have addressed whether trans fatty acids adversely affect fetal and infant neurodevelopment and growth. The interpretation of existing research and development of recommendations should be done cautiously. Suggestions for research to clarify these issues are made." @default.
• W4213293403 created "2022-02-24" @default.
• W4213293403 creator A5029988436 @default.
• W4213293403 creator A5032062108 @default.
• W4213293403 creator A5051551911 @default.
• W4213293403 creator A5052692732 @default.
• W4213293403 creator A5074107420 @default.
• W4213293403 date "1997-09-01" @default.
• W4213293403 modified "2023-10-18" @default.
• W4213293403 title "trans Fatty acids: infant and fetal development" @default.
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