Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213301235> ?p ?o ?g. }
- W4213301235 abstract "Parkinson’s disease (PD), the second most prevalent neurodegenerative disorder, manifests with motor and non-motor symptoms associated with two main pathological hallmarks, including the deterioration of dopaminergic cells and aggregation of alpha-synuclein. Yet, PD is a neurodegenerative process whose origin is uncertain and progression difficult to monitor and predict. Currently, a possibility is that PD may be secondary to long lasting peripheral affectations. In this regard, it has been shown that retinal degeneration is present in PD patients. Although it is unknown if retinal degeneration precedes PD motor symptoms, the possibility exists since degeneration of peripheral organs (e.g., olfaction, gut) have already been proven to antedate PD motor symptoms. In this paper, we explore this possibility by introducing the anatomical and functional relationship of retina and brain and providing an overview of the physiopathological changes of retinal structure and visual function in PD. On the basis of the current status of visual deficits in individuals with PD, we discuss the modalities and pathological mechanism of visual function or morphological changes in the retina and focus on the correlation between visual impairment and some representative structural features with clinical significance. To consider retinal degeneration as a contributor to PD origin and progress is important because PD evolution may be monitored and predicted by retinal studies through state-of-the-art techniques of the retina. It is significant to integrally understand the role of retinal morphological and functional changes in the neurodegenerative process for the diagnosis and therapeutic strategies of PD." @default.
- W4213301235 created "2022-02-24" @default.
- W4213301235 creator A5028335436 @default.
- W4213301235 creator A5033156367 @default.
- W4213301235 creator A5044939434 @default.
- W4213301235 creator A5063627915 @default.
- W4213301235 date "2022-02-04" @default.
- W4213301235 modified "2023-10-01" @default.
- W4213301235 title "Retinal Degeneration: A Window to Understand the Origin and Progression of Parkinson’s Disease?" @default.
- W4213301235 cites W1455914561 @default.
- W4213301235 cites W1510829714 @default.
- W4213301235 cites W1588278356 @default.
- W4213301235 cites W1621325175 @default.
- W4213301235 cites W1782945481 @default.
- W4213301235 cites W1829275570 @default.
- W4213301235 cites W1870853477 @default.
- W4213301235 cites W1899387222 @default.
- W4213301235 cites W1956487664 @default.
- W4213301235 cites W1958166723 @default.
- W4213301235 cites W1959222722 @default.
- W4213301235 cites W1963616735 @default.
- W4213301235 cites W1964384525 @default.
- W4213301235 cites W1969334748 @default.
- W4213301235 cites W1971588250 @default.
- W4213301235 cites W1972653353 @default.
- W4213301235 cites W1974244012 @default.
- W4213301235 cites W1974637884 @default.
- W4213301235 cites W1975944360 @default.
- W4213301235 cites W1977682751 @default.
- W4213301235 cites W1980547340 @default.
- W4213301235 cites W1982425634 @default.
- W4213301235 cites W1983444691 @default.
- W4213301235 cites W1984424982 @default.
- W4213301235 cites W1984714677 @default.
- W4213301235 cites W1987727007 @default.
- W4213301235 cites W1990473626 @default.
- W4213301235 cites W1991934654 @default.
- W4213301235 cites W1994911230 @default.
- W4213301235 cites W1995659482 @default.
- W4213301235 cites W1997773755 @default.
- W4213301235 cites W1998053127 @default.
- W4213301235 cites W1998256937 @default.
- W4213301235 cites W2002095325 @default.
- W4213301235 cites W2003129200 @default.
- W4213301235 cites W2004998121 @default.
- W4213301235 cites W2006086001 @default.
- W4213301235 cites W2007491035 @default.
- W4213301235 cites W2009130667 @default.
- W4213301235 cites W2011640809 @default.
- W4213301235 cites W2014572130 @default.
- W4213301235 cites W2015290866 @default.
- W4213301235 cites W2022197238 @default.
- W4213301235 cites W2024292109 @default.
- W4213301235 cites W2025099945 @default.
- W4213301235 cites W2025348767 @default.
- W4213301235 cites W2027068294 @default.
- W4213301235 cites W2028393630 @default.
- W4213301235 cites W2030366252 @default.
- W4213301235 cites W2032817175 @default.
- W4213301235 cites W2034018442 @default.
- W4213301235 cites W2035853180 @default.
- W4213301235 cites W2036867046 @default.
- W4213301235 cites W2042553854 @default.
- W4213301235 cites W2042844612 @default.
- W4213301235 cites W2047539147 @default.
- W4213301235 cites W2048157177 @default.
- W4213301235 cites W2049284641 @default.
- W4213301235 cites W2059261643 @default.
- W4213301235 cites W2062786827 @default.
- W4213301235 cites W2070255746 @default.
- W4213301235 cites W2071075531 @default.
- W4213301235 cites W2071909148 @default.
- W4213301235 cites W2072171013 @default.
- W4213301235 cites W2073194169 @default.
- W4213301235 cites W2075860804 @default.
- W4213301235 cites W2082718353 @default.
- W4213301235 cites W2087567950 @default.
- W4213301235 cites W2088389476 @default.
- W4213301235 cites W2088481573 @default.
- W4213301235 cites W2092491661 @default.
- W4213301235 cites W2092651397 @default.
- W4213301235 cites W2094641395 @default.
- W4213301235 cites W2098125634 @default.
- W4213301235 cites W2111015056 @default.
- W4213301235 cites W2112455323 @default.
- W4213301235 cites W2112741446 @default.
- W4213301235 cites W2113060901 @default.
- W4213301235 cites W2124181868 @default.
- W4213301235 cites W2124224192 @default.
- W4213301235 cites W2127931350 @default.
- W4213301235 cites W2134234992 @default.
- W4213301235 cites W2134276600 @default.
- W4213301235 cites W2134960067 @default.
- W4213301235 cites W2136558042 @default.
- W4213301235 cites W2141191071 @default.
- W4213301235 cites W2149502603 @default.
- W4213301235 cites W2152613502 @default.
- W4213301235 cites W2153064445 @default.
- W4213301235 cites W2158480093 @default.
- W4213301235 cites W2158535248 @default.