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• W4213302398 abstract "Little is known about the risk of diabetes due to higher glycemic variability and the underlying mechanisms. We aimed to examine the association of visit-to-visit variability (VVV) in fasting plasma glucose (FPG) with incident diabetes in Chinese adults and whether the association was mediated by changes in insulin resistance (IR).We included 1856 community residents without a history of diabetes and having attended 3 examinations in 2008, 2009, and 2013 respectively. The SD, the average successive variability (ASV), the coefficient of variation (CV), and the variability independent of the mean (VIM) of three recorded FPG measurements were calculated for each participant, and SD, ASV, CV, and VIM were used as a measure of VVV in FPG. Incident diabetes was defined according to the 1999 World Health Organization criteria. IR was evaluated using the homeostatic model assessment (HOMA).A total of 153 (8.2%) participants developed incident diabetes at the third visit. Compared with the lowest tertile (0-5.83 mg/dl) of FPG-SD, the highest tertile (9.55-74.17 mg/dl) was associated with a 148% increased risk of diabetes (odds ratio [OR], 2.48; 95% confidence interval [CI], 1.36-4.49), after adjustment for covariates including mean FPG at 3 visits. Mediation analyses suggested that changes in IR (ΔHOMA-IR) might mediate 17.3% of the association between increased FPG-SD and elevated diabetes risk. Similar results were found for FPG-CV, FPG-ASV, and FPG-VIM.The VVV in FPG was significantly associated with risks of diabetes in Chinese adults, which was partially mediated by changes in IR.背景: 由于较高的血糖变异性和潜在机制，人们对糖尿病的风险知之甚少。我们旨在研究中国成年人空腹血糖 (FPG) 的就诊间变异 (VVV) 与糖尿病发病的关系，以及这种关联是否由胰岛素抵抗 (IR)介导。 方法: 我们纳入了1856名无糖尿病病史的社区居民，分别于2008年, 2009年和2013年参加了3次检查。为每个参与者计算了3次FPG测量值的标准差 (SD), 平均连续变异性 (ASV), 变异系数 (CV) 和与平均值无关的变异性 (VIM) 。SD, ASV, CV和 VIM 被用作 FPG 中 VVV 的量度。根据 1999 年世界卫生组织标准定义糖尿病。使用稳态模型评估 (HOMA) 评估 IR。 结果: 共有 153 名 (8.2%) 参与者在第 3 次就诊时出现糖尿病。校正包括 3 次就诊时的平均 FPG在内的协变量后，与 FPG-SD 最低三分位数 (0 - 5.83 mg/dL) 相比，最高三分位数 (9.55-74.17 mg/dL) 糖尿病风险增加 148% (OR = 2.48, 95% CI 1.36-4.49)。中介分析表明，IR的变化(ΔHOMA-IR)可能介导 FPG-SD 增加与糖尿病风险升高之间 17.3% 的关联。对于 FPG-CV , FPG-ASV 和 FPG-VIM 也发现了类似的结果。 结论: FPG 中的 VVV 与中国成年人患糖尿病的风险显着相关，这部分是由 IR 的变化介导的。." @default.
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• W4213302398 date "2022-02-16" @default.
• W4213302398 modified "2023-10-16" @default.
• W4213302398 title "Impact of visit‐to‐visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance" @default.
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• W4213302398 doi "https://doi.org/10.1111/1753-0407.13253" @default.
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