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- W4213302418 abstract "Clinical theories of adaptation in bereavement highlight a need for flexible shifting between mental states. However, the prolonged motivational salience of the deceased partner may be a complicating factor, particularly when coupled with perseverative thinking about the loss. We investigated how prolonged grief might relate to resting state functional brain network connectivity in a sample of older adults (n = 38) who experienced the death of a partner 6-36 months prior, and whether intranasal oxytocin (as a neuropeptide involved in pair-bonding) had differential effects in participants with more prolonged grief symptoms. Higher scores on the Inventory of Complicated Grief (ICG) were associated with lower anticorrelation (i.e., higher functional connectivity) between the default-retrosplenial – cingulo-opercular-dACC network pair. Intranasal oxytocin increased coactivation the same default-retrosplenial – cingulo-opercular-dACC circuit but ICG scores did not moderate effects of oxytocin, contrary to our prediction. Higher ICG scores were associated with longer dwell time in a state characterized by in a dynamic functional connectivity state featuring positive correlations among default, frontoparietal, and cingulo-opercular networks across both placebo and oxytocin sessions. Dwell time was not significantly affected by oxytocin, and higher prolonged grief symptoms were not associated with more variability in dynamic functional connectivity states over the scan. Results offer preliminary evidence that prolonged grief symptoms in older adults are associated with patterns of static and time-varying functional connectivity, and may specifically involve a default network-salience-related circuit that is sensitive to oxytocin." @default.
- W4213302418 created "2022-02-24" @default.
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- W4213302418 date "2022-02-08" @default.
- W4213302418 modified "2023-10-14" @default.
- W4213302418 title "Dwelling in prolonged grief: Resting state functional connectivity during oxytocin and placebo administration" @default.
- W4213302418 doi "https://doi.org/10.31234/osf.io/qm5se" @default.
- W4213302418 hasPublicationYear "2022" @default.
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