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- W4213302582 abstract "Gastrulation movements are critical for establishing the three principal germ layers and the basic architecture of vertebrate embryos. Although the individual molecules and pathways involved are not clearly understood, non-canonical Wnt signals are known to participate in developmental processes, including planar cell polarity and directed cell rearrangements. Here we demonstrate that the dual-specificity transcriptional repressor Kaiso, first identified in association with p120-catenin, is required for Xenopus gastrulation movements. In addition, depletion of xKaiso results in increased expression of the non-canonical xWnt11, which contributes to the xKaiso knockdown phenotype as it is significantly rescued by dominant-negative Wnt11. We further demonstrate that xWnt11 is a direct gene target of xKaiso and that p120-catenin association relieves xKaiso repression in vivo. Our results indicate that p120-catenin and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis. PMID: 15543138 Funding information This work was supported by: NIGMS NIH HHS, United States Grant ID: R01 GM52112 NCI NIH HHS, United States Grant ID: CA-16672 NIGMS NIH HHS, United States Grant ID: R01 GM052112" @default.
- W4213302582 created "2022-02-24" @default.
- W4213302582 creator A5057871238 @default.
- W4213302582 date "2004-11-23" @default.
- W4213302582 modified "2023-10-16" @default.
- W4213302582 title "Faculty Opinions recommendation of Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin." @default.
- W4213302582 doi "https://doi.org/10.3410/f.1022446.255657" @default.
- W4213302582 hasPublicationYear "2004" @default.
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