Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213302731> ?p ?o ?g. }
- W4213302731 endingPage "2997" @default.
- W4213302731 startingPage "2985" @default.
- W4213302731 abstract "As a disease caused by an impaired intestinal epithelial barrier, imbalanced flora, immune imbalance and genetic susceptibility, ulcerative colitis (UC) is becoming a health threat for all ages. Lactobacillus acidophilus (L. acidophilus), an attracting probiotic, has already been confirmed to improve immune dysfunction, stabilize intestinal microflora, and combat gut disorders. However, no studies have focused on the effects of different forms of L. acidophilus on UC, and its mechanism involved in the mitophagy/NLRP3 inflammasome pathway has not been reported. In this study, we found that compared with the heat-killed L. acidophilus and the culture supernatant of L. acidophilus, the live L. acidophilus (La) has the optimal therapeutic effect on UC rats. Furthermore, La evidently increased the contents of SCFAs, inhibited NLRP3 inflammasome and facilitated autophagy. SCFAs regulated by La balanced inflammation homeostasis and improved intestinal barrier dysfunctions in vitro and in vivo, which was achieved by activating the mitophagy/NLRP3 inflammasome pathway. Moreover, PCR analysis indicated that the aforementioned effects of SCFAs regulated by La may be due to the activation of G protein-coupled receptors. These findings provided guidance for the application of L. acidophilus in daily life and provided a new molecular target for interactions among L. acidophilus, its metabolites and host immunity." @default.
- W4213302731 created "2022-02-24" @default.
- W4213302731 creator A5000865484 @default.
- W4213302731 creator A5003151279 @default.
- W4213302731 creator A5022557533 @default.
- W4213302731 creator A5027024676 @default.
- W4213302731 creator A5029347419 @default.
- W4213302731 creator A5032604539 @default.
- W4213302731 creator A5040558103 @default.
- W4213302731 creator A5040833095 @default.
- W4213302731 creator A5042062615 @default.
- W4213302731 creator A5048500794 @default.
- W4213302731 creator A5063403199 @default.
- W4213302731 creator A5070897693 @default.
- W4213302731 creator A5079607587 @default.
- W4213302731 date "2022-01-01" @default.
- W4213302731 modified "2023-10-15" @default.
- W4213302731 title "Live <i>Lactobacillus acidophilus</i> alleviates ulcerative colitis <i>via</i> the SCFAs/mitophagy/NLRP3 inflammasome axis" @default.
- W4213302731 cites W1954263225 @default.
- W4213302731 cites W1985538633 @default.
- W4213302731 cites W1993952186 @default.
- W4213302731 cites W2002394315 @default.
- W4213302731 cites W2011093795 @default.
- W4213302731 cites W2011817814 @default.
- W4213302731 cites W2024662833 @default.
- W4213302731 cites W2050614834 @default.
- W4213302731 cites W2050920580 @default.
- W4213302731 cites W2060185417 @default.
- W4213302731 cites W2060913934 @default.
- W4213302731 cites W2097697877 @default.
- W4213302731 cites W2118142243 @default.
- W4213302731 cites W2128933212 @default.
- W4213302731 cites W2143737916 @default.
- W4213302731 cites W2161310571 @default.
- W4213302731 cites W2166209782 @default.
- W4213302731 cites W2260651029 @default.
- W4213302731 cites W2282772932 @default.
- W4213302731 cites W2557994720 @default.
- W4213302731 cites W2741813146 @default.
- W4213302731 cites W2755513907 @default.
- W4213302731 cites W2793840364 @default.
- W4213302731 cites W2884808710 @default.
- W4213302731 cites W2893093138 @default.
- W4213302731 cites W2903402969 @default.
- W4213302731 cites W2905687525 @default.
- W4213302731 cites W2914734699 @default.
- W4213302731 cites W2919321004 @default.
- W4213302731 cites W2921966151 @default.
- W4213302731 cites W2923380089 @default.
- W4213302731 cites W2951593518 @default.
- W4213302731 cites W2952488879 @default.
- W4213302731 cites W2953588375 @default.
- W4213302731 cites W2958739722 @default.
- W4213302731 cites W3032537264 @default.
- W4213302731 cites W3034307226 @default.
- W4213302731 cites W3044420082 @default.
- W4213302731 cites W3081699858 @default.
- W4213302731 cites W3091947140 @default.
- W4213302731 cites W3127535628 @default.
- W4213302731 cites W3132197687 @default.
- W4213302731 cites W4210972027 @default.
- W4213302731 cites W4240698425 @default.
- W4213302731 doi "https://doi.org/10.1039/d1fo03360c" @default.
- W4213302731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35195119" @default.
- W4213302731 hasPublicationYear "2022" @default.
- W4213302731 type Work @default.
- W4213302731 citedByCount "17" @default.
- W4213302731 countsByYear W42133027312022 @default.
- W4213302731 countsByYear W42133027312023 @default.
- W4213302731 crossrefType "journal-article" @default.
- W4213302731 hasAuthorship W4213302731A5000865484 @default.
- W4213302731 hasAuthorship W4213302731A5003151279 @default.
- W4213302731 hasAuthorship W4213302731A5022557533 @default.
- W4213302731 hasAuthorship W4213302731A5027024676 @default.
- W4213302731 hasAuthorship W4213302731A5029347419 @default.
- W4213302731 hasAuthorship W4213302731A5032604539 @default.
- W4213302731 hasAuthorship W4213302731A5040558103 @default.
- W4213302731 hasAuthorship W4213302731A5040833095 @default.
- W4213302731 hasAuthorship W4213302731A5042062615 @default.
- W4213302731 hasAuthorship W4213302731A5048500794 @default.
- W4213302731 hasAuthorship W4213302731A5063403199 @default.
- W4213302731 hasAuthorship W4213302731A5070897693 @default.
- W4213302731 hasAuthorship W4213302731A5079607587 @default.
- W4213302731 hasConcept C126322002 @default.
- W4213302731 hasConcept C185592680 @default.
- W4213302731 hasConcept C190283241 @default.
- W4213302731 hasConcept C203014093 @default.
- W4213302731 hasConcept C203522944 @default.
- W4213302731 hasConcept C2775862500 @default.
- W4213302731 hasConcept C2776914184 @default.
- W4213302731 hasConcept C2777165150 @default.
- W4213302731 hasConcept C2777209026 @default.
- W4213302731 hasConcept C2777221637 @default.
- W4213302731 hasConcept C2779134260 @default.
- W4213302731 hasConcept C2779324830 @default.
- W4213302731 hasConcept C2780255968 @default.
- W4213302731 hasConcept C2780479503 @default.
- W4213302731 hasConcept C523546767 @default.