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- W4213303416 abstract "Abstract A series of novel 2-bromo-6-(4,5-diphenyl-1-((subtituted-phenyl-1 H -1,2,3-triazol-4-yl)methyl)-1 H -imidazol-2-yl)pyridine ( 7a-l ) were synthesized and characterized by various analytical techniques. All the synthesized compounds were evaluated for their in vitro anticancer activity against two human cancer cell lines such as HT-1080 (Human fibro sarcoma cells) and Caco-2(Human colorectal adenocarcinoma cells) and IC 50 values were compared against standard anticancer drug doxorubicin. Among all the synthesized compounds 7b , 7c and 7f has shown potent activity against HT-1080. Similarly compounds 7b and 7c shown significant activity among all the synthesized compounds against Caco-2. Furthermore, the results were supported by molecular docking studies." @default.
- W4213303416 created "2022-02-24" @default.
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- W4213303416 date "2022-02-14" @default.
- W4213303416 modified "2023-09-27" @default.
- W4213303416 title "Synthesis 2-Bromo-6-(4,5-Diphenyl-1-((1-Phenyl-1H-1,2,3-Triazol-4-yl) Methyl)-1H-Imidazol-2-yl) Pyridine Derivatives: Evaluation of Anticancer Activity and Molecular Docking Studies" @default.
- W4213303416 doi "https://doi.org/10.21203/rs.3.rs-1334374/v1" @default.
- W4213303416 hasPublicationYear "2022" @default.
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