FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213304790> ?p ?o ?g. }

• W4213304790 endingPage "100450" @default.
• W4213304790 startingPage "100450" @default.
• W4213304790 abstract "Psychological and life stressors may impact autoimmune hepatitis (AIH) disease activity and increase relapse risk. Mindfulness-based stress reduction (MBSR) is a validated course that reduces stress reactivity, and improves stress and emotion regulation. This single-arm exploratory pilot study of adult patients with AIH aimed to define the impact of an 8-week MBSR program on quality of life, disease activity, and cytokine mediators.The perceived stress survey-10 (PSS) and the brief self-control scale (BSCS) measured subjective distress and self-control. Serum alanine aminotransferase (ALT) and cytokine levels were measured, and immunosuppressant doses recorded.Seventeen patients completed the MBSR program. Post-MBSR, 71% (n = 12) showed PSS score improvement at 8 weeks vs. baseline (median 15 vs. 21, p = 0.02). At 12 months, PSS improvement persisted vs. baseline (median 15 vs. 21, p = 0.02). Post-MBSR, 71% (n = 12) showed BSCS score improvement at 8 weeks vs. baseline (median 4.1 vs. 3.8, p = 0.03). At 12 months, the median BSCS score remained significant (3.9 vs. 3.8, p = 0.03). After the 8-week MBSR, the 35% of patients with ALT >34 U/L had a median ALT reduction (44.5 vs. 71.5 U/L, p = 0.06), whereas the 71% of patients on prednisone had significant dose reductions (5.75 vs. 10 mg, p = 0.02) which persisted at 12 months vs. baseline (3.75 vs. 10 mg, p = 0.02) without a compensatory increase in steroid-sparing dosing. Significant improvement was noted in peripheral blood cytokine levels (IL-6, IL-8, IL-10, IL-17, IL-23, and sCD74/MIF ratio) from baseline to 8 weeks.MBSR significantly improved perceived stress and self-control scores while decreasing ALT levels, steroid requirements, and inflammatory cytokine levels in this pilot study in adult AIH. Stress modification may impact quality of life and disease activity, and should be further evaluated as an intervention in AIH.This study is registered at ClinicalTrials.gov (NCT02950077).Autoimmune hepatitis can reduce quality of life and mental health, while stress may impact autoimmune hepatitis itself. We piloted mindfulness-based stress reduction as a strategy to reduce stress in adult patients with autoimmune hepatitis and found that the intervention reduced perceived stress and may have also impacted the disease by improving inflammation and medication needs. Stress reduction should be further studied to improve quality of life and possibly to impact disease activity in autoimmune hepatitis." @default.
• W4213304790 created "2022-02-24" @default.
• W4213304790 creator A5008873320 @default.
• W4213304790 creator A5012853410 @default.
• W4213304790 creator A5014348793 @default.
• W4213304790 creator A5020017677 @default.
• W4213304790 creator A5029456441 @default.
• W4213304790 creator A5047186883 @default.
• W4213304790 creator A5048480496 @default.
• W4213304790 creator A5055130259 @default.
• W4213304790 creator A5062624256 @default.
• W4213304790 creator A5065684362 @default.
• W4213304790 creator A5089678594 @default.
• W4213304790 creator A5064858572 @default.
• W4213304790 date "2022-02-01" @default.
• W4213304790 modified "2023-09-26" @default.
• W4213304790 title "Mindfulness-Based Stress Reduction May Improve Stress, Disease Activity and Inflammatory Cytokine Levels in Autoimmune Hepatitis Patients" @default.
• W4213304790 cites W1796323099 @default.
• W4213304790 cites W1968115563 @default.
• W4213304790 cites W1968402898 @default.
• W4213304790 cites W1972531935 @default.
• W4213304790 cites W1989832114 @default.
• W4213304790 cites W1996299251 @default.
• W4213304790 cites W1999409201 @default.
• W4213304790 cites W2035352223 @default.
• W4213304790 cites W2048997301 @default.
• W4213304790 cites W2058821638 @default.
• W4213304790 cites W2062824264 @default.
• W4213304790 cites W2099365033 @default.
• W4213304790 cites W2099977782 @default.
• W4213304790 cites W2109732289 @default.
• W4213304790 cites W2124126925 @default.
• W4213304790 cites W2125315255 @default.
• W4213304790 cites W2132675308 @default.
• W4213304790 cites W2133747615 @default.
• W4213304790 cites W2134077691 @default.
• W4213304790 cites W2137219871 @default.
• W4213304790 cites W2145197581 @default.
• W4213304790 cites W2146972131 @default.
• W4213304790 cites W2154459716 @default.
• W4213304790 cites W2157337754 @default.
• W4213304790 cites W2165016477 @default.
• W4213304790 cites W2417597899 @default.
• W4213304790 cites W2576358775 @default.
• W4213304790 cites W2613560536 @default.
• W4213304790 cites W2789569198 @default.
• W4213304790 cites W2899453161 @default.
• W4213304790 cites W2951252030 @default.
• W4213304790 cites W2995815973 @default.
• W4213304790 cites W3014871259 @default.
• W4213304790 doi "https://doi.org/10.1016/j.jhepr.2022.100450" @default.
• W4213304790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35434588" @default.
• W4213304790 hasPublicationYear "2022" @default.
• W4213304790 type Work @default.
• W4213304790 citedByCount "1" @default.
• W4213304790 countsByYear W42133047902023 @default.
• W4213304790 crossrefType "journal-article" @default.
• W4213304790 hasAuthorship W4213304790A5008873320 @default.
• W4213304790 hasAuthorship W4213304790A5012853410 @default.
• W4213304790 hasAuthorship W4213304790A5014348793 @default.
• W4213304790 hasAuthorship W4213304790A5020017677 @default.
• W4213304790 hasAuthorship W4213304790A5029456441 @default.
• W4213304790 hasAuthorship W4213304790A5047186883 @default.
• W4213304790 hasAuthorship W4213304790A5048480496 @default.
• W4213304790 hasAuthorship W4213304790A5055130259 @default.
• W4213304790 hasAuthorship W4213304790A5062624256 @default.
• W4213304790 hasAuthorship W4213304790A5064858572 @default.
• W4213304790 hasAuthorship W4213304790A5065684362 @default.
• W4213304790 hasAuthorship W4213304790A5089678594 @default.
• W4213304790 hasBestOaLocation W42133047902 @default.
• W4213304790 hasConcept C126322002 @default.
• W4213304790 hasConcept C138885662 @default.
• W4213304790 hasConcept C139265228 @default.
• W4213304790 hasConcept C159110408 @default.
• W4213304790 hasConcept C168563851 @default.
• W4213304790 hasConcept C21036866 @default.
• W4213304790 hasConcept C2777203481 @default.
• W4213304790 hasConcept C2777772685 @default.
• W4213304790 hasConcept C2778690821 @default.
• W4213304790 hasConcept C2778720950 @default.
• W4213304790 hasConcept C2779134260 @default.
• W4213304790 hasConcept C2779870332 @default.
• W4213304790 hasConcept C2779951463 @default.
• W4213304790 hasConcept C2780444219 @default.
• W4213304790 hasConcept C41895202 @default.
• W4213304790 hasConcept C70410870 @default.
• W4213304790 hasConcept C71924100 @default.
• W4213304790 hasConcept C90924648 @default.
• W4213304790 hasConceptScore W4213304790C126322002 @default.
• W4213304790 hasConceptScore W4213304790C138885662 @default.
• W4213304790 hasConceptScore W4213304790C139265228 @default.
• W4213304790 hasConceptScore W4213304790C159110408 @default.
• W4213304790 hasConceptScore W4213304790C168563851 @default.
• W4213304790 hasConceptScore W4213304790C21036866 @default.
• W4213304790 hasConceptScore W4213304790C2777203481 @default.
• W4213304790 hasConceptScore W4213304790C2777772685 @default.
• W4213304790 hasConceptScore W4213304790C2778690821 @default.
• W4213304790 hasConceptScore W4213304790C2778720950 @default.

• next