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• W4213306086 endingPage "3734" @default.
• W4213306086 startingPage "3727" @default.
• W4213306086 abstract "The real-time tracking and efficacy evaluation of therapeutic nanoplatforms especially in deep-tissues is of great importance but faces challenges. Meanwhile, chemodynamic therapy (CDT), relying on Fenton reaction by converting H2O2 into toxic hydroxyl radicals (•OH), has drawn wide interests in the fabrication of nanozymes for tumor therapy, while endogenous H2O2 is usually insufficient for effective CDT. Here, we report the pH-responsive multifunctional nanoplatforms consisting of copper peroxide (CP) nanoparticles, paclitaxel (PTX) and perfluoro-15-crown-5-ether (PFCE), for 19F magnetic resonance imaging guided and enhanced chemo-chemodynamic synergetic therapy with self-supplied H2O2 stemmed from the decomposition of CP nanoparticles under acid conditions in tumor. The decomposition of CP nanoparticles further promotes the release of PTX for enhanced chemotherapy. Both in vitro and in vivo results indicate that the efficient generation of •OH and drug release effectively inhibits tumor growth. Furthermore, 19F MRI signal can clearly track the fate of nanoplatforms in tumor and guide tumor treatment. This work provides a promising strategy for the rational design and construction of multifunctional nanoplatforms for imaging-guided synergistic therapy of deep seated tumor." @default.
• W4213306086 created "2022-02-24" @default.
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• W4213306086 date "2022-02-20" @default.
• W4213306086 modified "2023-10-17" @default.
• W4213306086 title "Acid-Triggered H₂O₂ Self-Supplying Nanoplatform for ¹⁹F-MRI with Enhanced Chemo–Chemodynamic Therapy" @default.
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• W4213306086 doi "https://doi.org/10.1021/acs.analchem.2c00023" @default.
• W4213306086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35184546" @default.
• W4213306086 hasPublicationYear "2022" @default.
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