Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213306317> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4213306317 endingPage "074823372110629" @default.
- W4213306317 startingPage "074823372110629" @default.
- W4213306317 abstract "Hard metal lung disease (HMLD) drugs include dexamethasone sodium phosphate (Dex), methylprednisolone (MP) injection, N-acetylcysteine injection (NAC), and a mix of Dex, MP, and NAC (MIX). In this study, we compared the effects of these drugs on different cytokines of hard metal lung disease in a rat model. Thirty-six adult female Sprague Dawley rats were distributed equally into the control group, hard metal (HM) group, Dex group, MP group, NAC group, and MIX group. HM powder (0.5 mL, 20 mg/mL; one time) was administered by intraperitoneal injection to the HM group through the pulmonary endotracheal tube, while the control group received normal saline (0.5 mL, 20 mg/mL; one time). After 4 weeks, the drugs were administered to the experimental groups (0.5 mL, 20 mg/mL; one time). After 8 weeks, bronchoalveolar lavage fluid (BALF) and serum were examined for cytokine levels. Biochemical analysis indicated that the Dex, MP, NAC, and MIX did not improve TGF-β1, TGF-β2, KL-6, and MMP-1 in the BALF, while MIX increased TIMP-1 in BALF. In addition, the NAC treatment significantly increased the expression levels of TGF-β1, TGF-β2, KL-6, and MMP-1. The MIX treatment significantly increased the expression levels of TGF-β1, TGF-β2, and KL-6. The MP treatment significantly increased the expression levels of KL-6, and MMP-1. The Dex treatment significantly increased the expression levels of TGF-β1, KL-6, and MMP-1. This study demonstrated that administered with NAC and MIX could improve TGF-β1, TGF-β2, and KL-6 in serum of hard metal lung disease in a rat model. Therefore, NAC injection may be considered a useful candidate in the development of a preventive agent against HMLD." @default.
- W4213306317 created "2022-02-24" @default.
- W4213306317 creator A5001997456 @default.
- W4213306317 creator A5022585880 @default.
- W4213306317 creator A5026472765 @default.
- W4213306317 creator A5033856784 @default.
- W4213306317 creator A5035498561 @default.
- W4213306317 creator A5082580867 @default.
- W4213306317 date "2022-02-22" @default.
- W4213306317 modified "2023-09-25" @default.
- W4213306317 title "The effect of different drugs on hard metal lung disease in a rat model" @default.
- W4213306317 cites W1977735845 @default.
- W4213306317 cites W2010966889 @default.
- W4213306317 cites W2025663632 @default.
- W4213306317 cites W2041534524 @default.
- W4213306317 cites W2048567081 @default.
- W4213306317 cites W2070832048 @default.
- W4213306317 cites W2159884749 @default.
- W4213306317 cites W2174291484 @default.
- W4213306317 cites W2330658156 @default.
- W4213306317 cites W2914145050 @default.
- W4213306317 cites W3088477802 @default.
- W4213306317 cites W3134595178 @default.
- W4213306317 doi "https://doi.org/10.1177/07482337211062973" @default.
- W4213306317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35191764" @default.
- W4213306317 hasPublicationYear "2022" @default.
- W4213306317 type Work @default.
- W4213306317 citedByCount "0" @default.
- W4213306317 crossrefType "journal-article" @default.
- W4213306317 hasAuthorship W4213306317A5001997456 @default.
- W4213306317 hasAuthorship W4213306317A5022585880 @default.
- W4213306317 hasAuthorship W4213306317A5026472765 @default.
- W4213306317 hasAuthorship W4213306317A5033856784 @default.
- W4213306317 hasAuthorship W4213306317A5035498561 @default.
- W4213306317 hasAuthorship W4213306317A5082580867 @default.
- W4213306317 hasConcept C126322002 @default.
- W4213306317 hasConcept C185592680 @default.
- W4213306317 hasConcept C203014093 @default.
- W4213306317 hasConcept C2777397205 @default.
- W4213306317 hasConcept C2777714996 @default.
- W4213306317 hasConcept C2777961210 @default.
- W4213306317 hasConcept C2778690821 @default.
- W4213306317 hasConcept C2780159080 @default.
- W4213306317 hasConcept C2780372218 @default.
- W4213306317 hasConcept C2780401358 @default.
- W4213306317 hasConcept C71924100 @default.
- W4213306317 hasConcept C98274493 @default.
- W4213306317 hasConceptScore W4213306317C126322002 @default.
- W4213306317 hasConceptScore W4213306317C185592680 @default.
- W4213306317 hasConceptScore W4213306317C203014093 @default.
- W4213306317 hasConceptScore W4213306317C2777397205 @default.
- W4213306317 hasConceptScore W4213306317C2777714996 @default.
- W4213306317 hasConceptScore W4213306317C2777961210 @default.
- W4213306317 hasConceptScore W4213306317C2778690821 @default.
- W4213306317 hasConceptScore W4213306317C2780159080 @default.
- W4213306317 hasConceptScore W4213306317C2780372218 @default.
- W4213306317 hasConceptScore W4213306317C2780401358 @default.
- W4213306317 hasConceptScore W4213306317C71924100 @default.
- W4213306317 hasConceptScore W4213306317C98274493 @default.
- W4213306317 hasLocation W42133063171 @default.
- W4213306317 hasLocation W42133063172 @default.
- W4213306317 hasOpenAccess W4213306317 @default.
- W4213306317 hasPrimaryLocation W42133063171 @default.
- W4213306317 hasRelatedWork W1000056 @default.
- W4213306317 hasRelatedWork W1241465 @default.
- W4213306317 hasRelatedWork W13043411 @default.
- W4213306317 hasRelatedWork W1402687 @default.
- W4213306317 hasRelatedWork W17106945 @default.
- W4213306317 hasRelatedWork W3837942 @default.
- W4213306317 hasRelatedWork W7825235 @default.
- W4213306317 hasRelatedWork W9497463 @default.
- W4213306317 hasRelatedWork W9670700 @default.
- W4213306317 hasRelatedWork W3101893 @default.
- W4213306317 isParatext "false" @default.
- W4213306317 isRetracted "false" @default.
- W4213306317 workType "article" @default.