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- W4213306638 abstract "SUMMARY Acne vulgaris is a common neutrophile-driven inflammatory skin disorder in which Cutibacterium acnes ( C. acnes ) bacteria play a significant role. Until now, antibiotics have been widely used to treat acne vulgaris, with the inevitable increase in bacterial antibiotic resistance. Phage therapy is a promising solution to the rising problem of antibiotic-resistant bacteria, utilizing viruses that specifically lyse bacteria. Here, we explored the feasibility of phage therapy against C. acnes . By combining eight novel phages we had isolated, together with commonly used antibiotics, we achieved 100% eradication of clinically isolated C. acnes strains. Using topical phage therapy in an acne mouse model resulted in significantly superior clinical scores, as well as a reduction in neutrophil infiltration compared to the control group. These results demonstrate the potential of phage therapy in acne vulgaris treatment, especially when antibiotic-resistant strains are involved." @default.
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- W4213306638 date "2022-02-19" @default.
- W4213306638 modified "2023-09-25" @default.
- W4213306638 title "Towards phage therapy for acne vulgaris: Topical application in a mouse model" @default.
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- W4213306638 doi "https://doi.org/10.1101/2022.02.19.481124" @default.
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