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- W4213306774 abstract "Herein is described the development of an intensified continuous flow process for the preparation of a library of alkyl phosphonates through a Michaelis–Arbuzov rearrangement. A careful process optimization and thorough analysis of the competitive reactions led to a very attractive protocol with unprecedented productivities (up to 4.97 kg of material per day) and a low environmental footprint with the absence of solvent, additives, catalysts, and waste. In-line low-field 31P NMR monitoring was conveniently implemented for rapid optimization and process monitoring. Two key alkyl phosphonate intermediates were also assessed for the unprecedented diazene dicarboxylate-mediated electrophilic amination under continuous flow conditions toward the α-aminophosphonic acid derivatives of Pphenylalanine and Palanine, bioisosters of the natural amino acids phenylalanine and alanine, respectively." @default.
- W4213306774 created "2022-02-24" @default.
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- W4213306774 date "2022-02-08" @default.
- W4213306774 modified "2023-09-25" @default.
- W4213306774 title "Intensified Continuous Flow Michaelis–Arbuzov Rearrangement toward Alkyl Phosphonates" @default.
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- W4213306774 doi "https://doi.org/10.1021/acs.oprd.1c00472" @default.
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