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- W4213306921 abstract "Trichotillomania (TTM) is a body-focused repetitive disorder affecting as much as 0.5 to 2% of the population, with women four times more likely to be affected than men. This disorder causes impairment in daily function and significant distress. A potential animal model for this disorder is the inbred C57BL/6J mouse which displays clinical signs and behavioral characteristics similar to those described for people affected by this disorder. Because alcohol-preferring P rats also display similar clinical signs and behavioral characteristics, it was hypothesized that this selectively bred stock could be an additional animal model. In this study, 112 female P rats were recorded on digital media for 15 min after being sprayed with a mist of water and assessed for grooming patterns-oral, manual, and scratching. Significant elevations in scratching and oral grooming behavior were predictive of the future development of skin lesions. These findings suggest that P rats may be an additional model to study TTM, with the advantage of increased genetic variation (i.e., non-inbred) which mirrors the human population. The use of this model may help to identify preventative and therapeutic interventions for humans and other animals with similar body-focused repetitive disorders." @default.
- W4213306921 created "2022-02-24" @default.
- W4213306921 creator A5059562957 @default.
- W4213306921 creator A5080273132 @default.
- W4213306921 creator A5091441459 @default.
- W4213306921 date "2022-02-18" @default.
- W4213306921 modified "2023-10-14" @default.
- W4213306921 title "Predictive Value of Grooming Behavior for Development of Dermatitis in Selectively Bred P Rats as a Model of Trichotillomania Hair Pulling Disorder" @default.
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- W4213306921 doi "https://doi.org/10.3390/vetsci9020089" @default.
- W4213306921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35202342" @default.
- W4213306921 hasPublicationYear "2022" @default.
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