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• W4213307849 endingPage "115117" @default.
• W4213307849 startingPage "115117" @default.
• W4213307849 abstract "Nonalcoholic fatty liver disease (NAFLD) is one of the most common hepatic diseases closely intertwined with saturated fatty acids intake. Therefore, various studies are being conducted to find natural substances to prevent either the onset or progression of NAFLD. According to traditional medicinal literature, it has been reported that Gryllus bimaculatus De Geer (GB) has systemic detoxifying activity; however, the preventive effects of GB on NAFLD have not been elucidated to date.To evaluate the potential of GB as a material for the mitigation of NAFLD, we investigated the effects of GB hydrolysates on the hepatic lipid accumulation, inflammation, and endoplasmic reticulum (ER) stress in human hepatoma G2 (Hep G2) cells treated with palmitic acid (PA).Steamed and dried GB was defatted, pulverized, and then lyophilized following hydrolyzation using Neutrase® (GB-N) or Flavourzyme® (GB-F). Hep G2 cells were incubated with GB-N or GB-F at various concentrations (0, 0.25, 0.5, and 1 mg/mL) for 24 h, and then PA was treated for another 24 h.The GB-N and GB-F significantly prevented the PA-induced intracellular lipid accumulation in the human liver cells (p < 0.05). Moreover, the GB-N and GB-F increased the hepatic cellular viability against the PA-treatment (p < 0.05). In addition, the GB-N and GB-F significantly ameliorated the PA-inducible proinflammatory cytokines mRNA expression, such as tumor necrosis factor-α and interleukin-1β, compared to the PA-treated hepatic cells (p < 0.05). Furthermore, the GB-N and GB-F inhibited the PA-inducible lipogenic mRNA expression, such as fatty acid synthase, sterol regulatory element-binding protein 1c, and peroxisome proliferator-activated receptor-γ (p < 0.05). Moreover, the GB-N and GB-F alleviated the ER stress-related mRNA expression, such as glucose regulatory protein 78 and X-box binding protein increased in PA-treated cells (p < 0.05).These results indicate that GB-N and GB-F could be used as materials to prevent the NAFLD onset or progression with alleviating hepatic lipid accumulation, inflammation, and ER stress." @default.
• W4213307849 created "2022-02-24" @default.
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• W4213307849 date "2022-06-01" @default.
• W4213307849 modified "2023-10-17" @default.
• W4213307849 title "Gryllus bimaculatus De Geer hydrolysates alleviate lipid accumulation, inflammation, and endoplasmic reticulum stress in palmitic acid-treated human hepatoma G2 cells" @default.
• W4213307849 cites W1149988638 @default.
• W4213307849 cites W1555460575 @default.
• W4213307849 cites W1973615548 @default.
• W4213307849 cites W1974863952 @default.
• W4213307849 cites W1985478480 @default.
• W4213307849 cites W1985592156 @default.
• W4213307849 cites W1986529729 @default.
• W4213307849 cites W1991703131 @default.
• W4213307849 cites W1997901667 @default.
• W4213307849 cites W2003898413 @default.
• W4213307849 cites W2015171124 @default.
• W4213307849 cites W2025482327 @default.
• W4213307849 cites W2027021131 @default.
• W4213307849 cites W2029154623 @default.
• W4213307849 cites W2031815559 @default.
• W4213307849 cites W2036749599 @default.
• W4213307849 cites W2037721135 @default.
• W4213307849 cites W2042324298 @default.
• W4213307849 cites W2045107424 @default.
• W4213307849 cites W2047253953 @default.
• W4213307849 cites W2048375374 @default.
• W4213307849 cites W2053281570 @default.
• W4213307849 cites W2055473817 @default.
• W4213307849 cites W2062059387 @default.
• W4213307849 cites W2066453798 @default.
• W4213307849 cites W2066538173 @default.
• W4213307849 cites W2086066803 @default.
• W4213307849 cites W2086402582 @default.
• W4213307849 cites W2091330563 @default.
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• W4213307849 cites W2159265751 @default.
• W4213307849 cites W2172115472 @default.
• W4213307849 cites W2182670456 @default.
• W4213307849 cites W2204688218 @default.
• W4213307849 cites W2255971081 @default.
• W4213307849 cites W2291173445 @default.
• W4213307849 cites W2506621546 @default.
• W4213307849 cites W2512960672 @default.
• W4213307849 cites W2557879692 @default.
• W4213307849 cites W2581627825 @default.
• W4213307849 cites W2759997926 @default.
• W4213307849 cites W2793253924 @default.
• W4213307849 cites W2802378591 @default.
• W4213307849 cites W2805843671 @default.
• W4213307849 cites W2810287187 @default.
• W4213307849 cites W2879322985 @default.
• W4213307849 cites W2883966014 @default.
• W4213307849 cites W2886921259 @default.
• W4213307849 cites W2890663139 @default.
• W4213307849 cites W2901614104 @default.
• W4213307849 cites W2911836516 @default.
• W4213307849 cites W2936995226 @default.
• W4213307849 cites W2947257201 @default.
• W4213307849 cites W2953955004 @default.
• W4213307849 cites W2971267722 @default.
• W4213307849 cites W2975461564 @default.
• W4213307849 cites W2996363621 @default.
• W4213307849 cites W3015065664 @default.
• W4213307849 cites W3019578046 @default.
• W4213307849 cites W3040273961 @default.
• W4213307849 cites W3106696517 @default.
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• W4213307849 cites W3113184829 @default.
• W4213307849 cites W3118957675 @default.
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• W4213307849 doi "https://doi.org/10.1016/j.jep.2022.115117" @default.
• W4213307849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35182670" @default.
• W4213307849 hasPublicationYear "2022" @default.
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