FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213308312> ?p ?o ?g. }

• W4213308312 abstract "Abstract Background Genetic variations in the inflammatory Caspase-1 gene have been shown associated with cognitive function in elderly individuals and in predisposition to Alzheimer’s disease (AD), but its detailed mechanism before the typical AD onset was still unclear. Our current study evaluated the impact of Caspase-1 common variant rs554344 on the pathological processes of brain amyloidosis, tauopathy, and neurodegeneration. Methods Data used in our study were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. We examined the relationship between Caspase-1 rs554344 allele carrier status with AD-related cerebrospinal fluid (CSF), PET, and MRI measures at baseline by using a multiple linear regression model. We also analyzed the longitudinal effects of this variant on the change rates of CSF biomarkers and imaging data using a mixed effect model. Results We found that Caspase-1 variant was significantly associated with FDG PET levels and CSF t-tau levels at baseline in total non-demented elderly group, and especially in mild cognitive impairment (MCI) subgroup. In addition, this variant was also detected associated with CSF p-tau levels in MCI subgroup. The mediation analysis showed that CSF p-tau partially mediated the association between Caspase-1 variant and CSF t-tau levels, accounting for 80% of the total effect. Conclusions Our study indicated a potential role of Caspase-1 variant in influencing cognitive function might through changing tau related-neurodegeneration process." @default.
• W4213308312 created "2022-02-24" @default.
• W4213308312 creator A5008659449 @default.
• W4213308312 creator A5037071314 @default.
• W4213308312 creator A5067212579 @default.
• W4213308312 creator A5068665390 @default.
• W4213308312 creator A5087649543 @default.
• W4213308312 date "2022-02-16" @default.
• W4213308312 modified "2023-10-18" @default.
• W4213308312 title "Caspase-1 variant influencing CSF tau and FDG PET levels in non-demented elders from the ADNI cohort" @default.
• W4213308312 cites W1841850981 @default.
• W4213308312 cites W1971440513 @default.
• W4213308312 cites W1993976394 @default.
• W4213308312 cites W2017922747 @default.
• W4213308312 cites W2061590643 @default.
• W4213308312 cites W2066792703 @default.
• W4213308312 cites W2078524519 @default.
• W4213308312 cites W2079540265 @default.
• W4213308312 cites W2092817697 @default.
• W4213308312 cites W2114108415 @default.
• W4213308312 cites W2119098586 @default.
• W4213308312 cites W2129497119 @default.
• W4213308312 cites W2133652086 @default.
• W4213308312 cites W2150107812 @default.
• W4213308312 cites W2165840723 @default.
• W4213308312 cites W2291436232 @default.
• W4213308312 cites W2418806051 @default.
• W4213308312 cites W2613251848 @default.
• W4213308312 cites W2735217968 @default.
• W4213308312 cites W2742525598 @default.
• W4213308312 cites W2798054687 @default.
• W4213308312 cites W2886313134 @default.
• W4213308312 cites W2891569200 @default.
• W4213308312 cites W2900726683 @default.
• W4213308312 cites W2966191040 @default.
• W4213308312 cites W2990312754 @default.
• W4213308312 cites W3085790690 @default.
• W4213308312 cites W3119287108 @default.
• W4213308312 doi "https://doi.org/10.1186/s12883-022-02582-9" @default.
• W4213308312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35172755" @default.
• W4213308312 hasPublicationYear "2022" @default.
• W4213308312 type Work @default.
• W4213308312 citedByCount "1" @default.
• W4213308312 countsByYear W42133083122022 @default.
• W4213308312 crossrefType "journal-article" @default.
• W4213308312 hasAuthorship W4213308312A5008659449 @default.
• W4213308312 hasAuthorship W4213308312A5037071314 @default.
• W4213308312 hasAuthorship W4213308312A5067212579 @default.
• W4213308312 hasAuthorship W4213308312A5068665390 @default.
• W4213308312 hasAuthorship W4213308312A5087649543 @default.
• W4213308312 hasBestOaLocation W42133083121 @default.
• W4213308312 hasConcept C118552586 @default.
• W4213308312 hasConcept C126322002 @default.
• W4213308312 hasConcept C143998085 @default.
• W4213308312 hasConcept C16568411 @default.
• W4213308312 hasConcept C2776925932 @default.
• W4213308312 hasConcept C2777739294 @default.
• W4213308312 hasConcept C2778373026 @default.
• W4213308312 hasConcept C2779134260 @default.
• W4213308312 hasConcept C2779483572 @default.
• W4213308312 hasConcept C2779651940 @default.
• W4213308312 hasConcept C39920043 @default.
• W4213308312 hasConcept C502032728 @default.
• W4213308312 hasConcept C58693492 @default.
• W4213308312 hasConcept C71924100 @default.
• W4213308312 hasConcept C72563966 @default.
• W4213308312 hasConceptScore W4213308312C118552586 @default.
• W4213308312 hasConceptScore W4213308312C126322002 @default.
• W4213308312 hasConceptScore W4213308312C143998085 @default.
• W4213308312 hasConceptScore W4213308312C16568411 @default.
• W4213308312 hasConceptScore W4213308312C2776925932 @default.
• W4213308312 hasConceptScore W4213308312C2777739294 @default.
• W4213308312 hasConceptScore W4213308312C2778373026 @default.
• W4213308312 hasConceptScore W4213308312C2779134260 @default.
• W4213308312 hasConceptScore W4213308312C2779483572 @default.
• W4213308312 hasConceptScore W4213308312C2779651940 @default.
• W4213308312 hasConceptScore W4213308312C39920043 @default.
• W4213308312 hasConceptScore W4213308312C502032728 @default.
• W4213308312 hasConceptScore W4213308312C58693492 @default.
• W4213308312 hasConceptScore W4213308312C71924100 @default.
• W4213308312 hasConceptScore W4213308312C72563966 @default.
• W4213308312 hasIssue "1" @default.
• W4213308312 hasLocation W42133083121 @default.
• W4213308312 hasLocation W42133083122 @default.
• W4213308312 hasLocation W42133083123 @default.
• W4213308312 hasLocation W42133083124 @default.
• W4213308312 hasOpenAccess W4213308312 @default.
• W4213308312 hasPrimaryLocation W42133083121 @default.
• W4213308312 hasRelatedWork W1540168105 @default.
• W4213308312 hasRelatedWork W1986398611 @default.
• W4213308312 hasRelatedWork W2017059429 @default.
• W4213308312 hasRelatedWork W2055053022 @default.
• W4213308312 hasRelatedWork W2894253368 @default.
• W4213308312 hasRelatedWork W2902622269 @default.
• W4213308312 hasRelatedWork W2917267929 @default.
• W4213308312 hasRelatedWork W313460363 @default.
• W4213308312 hasRelatedWork W3165789732 @default.
• W4213308312 hasRelatedWork W957547037 @default.
• W4213308312 hasVolume "22" @default.
• W4213308312 isParatext "false" @default.

• next