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• W4213308675 endingPage "118761" @default.
• W4213308675 startingPage "118761" @default.
• W4213308675 abstract "Aggregation of a protein is associated with several biological and industrial processes: some wanted and some unwanted. An understanding of the mechanism of modulation of aggregation is, thus, required for designing strategies for the prevention/enhancement of amyloids. Misfolding and aggregation of human Cu-Zn superoxide dismutase (SOD1) into amyloid aggregates is a hallmark of a fatal neurodegenerative disease, amyotrophic lateral sclerosis (ALS). Therefore, targeting SOD1 protein could be a good choice for understanding the mechanism of SOD1 pathology in ALS. Here, we study the inhibitory effect of ammonium and choline based ionic liquids (ILs) (tetrabutylammonium methanesulfonate (TBAMS), tetrabutylammonium chloride (TBACl) and choline chloride (CholCl) on amyloid aggregation of SOD1 and explore how ILs modulate the formation of amyloid aggregates. We demonstrate that aqueous solutions of TBAMS and TBACl effectively inhibit SOD1 fibrillation, and their inhibitory effect increased with increasing the concentration. Conversely, CholCl has been found to act as an amyloid inhibitor at lower concentrations by acting at the elongation step and as an amyloid promoter at higher concentrations. Our experimental results showed that TBAMS and TBACl induce the formation of compact structures with reduced hydrophobicity. Theoretical analysis revealed that ILs stabilize Zn binding loop and electrostatic loop which play an important role in the structure and function of SOD1. These findings provide important insights about using IL as an anti-amyloidal agent for other amyloidogenic proteins and help to design effective modulators for protein aggregation." @default.
• W4213308675 created "2022-02-24" @default.
• W4213308675 creator A5021774821 @default.
• W4213308675 creator A5052161031 @default.
• W4213308675 creator A5068883180 @default.
• W4213308675 date "2022-05-01" @default.
• W4213308675 modified "2023-09-29" @default.
• W4213308675 title "Tetrabutylammonium based ionic liquids (ILs) inhibit the amyloid aggregation of superoxide dismutase 1 (SOD1)" @default.
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