FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213331652> ?p ?o ?g. }

• W4213331652 endingPage "385" @default.
• W4213331652 startingPage "385" @default.
• W4213331652 abstract "The SARS-CoV-2 pandemic has urged the development of protective vaccines and the search for specific antiviral drugs. The modern molecular biology tools provides alternative methods, such as CRISPR-Cas and RNA interference, that can be adapted as antiviral approaches, and contribute to this search. The unique CRISPR-Cas13d system, with the small crRNA guide molecule, mediates a sequence-specific attack on RNA, and can be developed as an anti-coronavirus strategy. We analyzed the SARS-CoV-2 genome to localize the hypothetically best crRNA-annealing sites of 23 nucleotides based on our extensive expertise with sequence-specific antiviral strategies. We considered target sites of which the sequence is well-conserved among SARS-CoV-2 isolates. As we should prepare for a potential future outbreak of related viruses, we screened for targets that are conserved between SARS-CoV-2 and SARS-CoV. To further broaden the search, we screened for targets that are conserved between SARS-CoV-2 and the more distantly related MERS-CoV, as well as the four other human coronaviruses (OC43, 229E, NL63, HKU1). Finally, we performed a search for pan-corona target sequences that are conserved among all these coronaviruses, including the new Omicron variant, that are able to replicate in humans. This survey may contribute to the design of effective, safe, and escape-proof antiviral strategies to prepare for future pandemics." @default.
• W4213331652 created "2022-02-24" @default.
• W4213331652 creator A5019287445 @default.
• W4213331652 creator A5048029605 @default.
• W4213331652 creator A5061955208 @default.
• W4213331652 creator A5071247753 @default.
• W4213331652 date "2022-02-14" @default.
• W4213331652 modified "2023-10-14" @default.
• W4213331652 title "In Silico Prediction and Selection of Target Sequences in the SARS-CoV-2 RNA Genome for an Antiviral Attack" @default.
• W4213331652 cites W1586964416 @default.
• W4213331652 cites W1811783050 @default.
• W4213331652 cites W1971643509 @default.
• W4213331652 cites W1977992713 @default.
• W4213331652 cites W1978094899 @default.
• W4213331652 cites W1990636994 @default.
• W4213331652 cites W1995420096 @default.
• W4213331652 cites W1996030981 @default.
• W4213331652 cites W2004823446 @default.
• W4213331652 cites W2008811126 @default.
• W4213331652 cites W2017642141 @default.
• W4213331652 cites W2019387053 @default.
• W4213331652 cites W2019431237 @default.
• W4213331652 cites W2027230618 @default.
• W4213331652 cites W2028366746 @default.
• W4213331652 cites W2032909659 @default.
• W4213331652 cites W2034555411 @default.
• W4213331652 cites W2037805800 @default.
• W4213331652 cites W2049023031 @default.
• W4213331652 cites W2050480410 @default.
• W4213331652 cites W2055313639 @default.
• W4213331652 cites W2090522366 @default.
• W4213331652 cites W2093605534 @default.
• W4213331652 cites W2099731870 @default.
• W4213331652 cites W2099747733 @default.
• W4213331652 cites W2102229939 @default.
• W4213331652 cites W2103503670 @default.
• W4213331652 cites W2104548316 @default.
• W4213331652 cites W2105111946 @default.
• W4213331652 cites W2111412754 @default.
• W4213331652 cites W2113513945 @default.
• W4213331652 cites W2113927019 @default.
• W4213331652 cites W2116267379 @default.
• W4213331652 cites W2117266879 @default.
• W4213331652 cites W2124985265 @default.
• W4213331652 cites W2132038944 @default.
• W4213331652 cites W2132260239 @default.
• W4213331652 cites W2133876293 @default.
• W4213331652 cites W2133898735 @default.
• W4213331652 cites W2134061616 @default.
• W4213331652 cites W2134653938 @default.
• W4213331652 cites W2137126048 @default.
• W4213331652 cites W2140056182 @default.
• W4213331652 cites W2142244438 @default.
• W4213331652 cites W2142678478 @default.
• W4213331652 cites W2142838180 @default.
• W4213331652 cites W2149221950 @default.
• W4213331652 cites W2149751339 @default.
• W4213331652 cites W2160378127 @default.
• W4213331652 cites W2163502548 @default.
• W4213331652 cites W2166802510 @default.
• W4213331652 cites W2166867592 @default.
• W4213331652 cites W2169244146 @default.
• W4213331652 cites W2170781554 @default.
• W4213331652 cites W2222445509 @default.
• W4213331652 cites W2306794997 @default.
• W4213331652 cites W2313699058 @default.
• W4213331652 cites W2332629841 @default.
• W4213331652 cites W2403996536 @default.
• W4213331652 cites W2409671300 @default.
• W4213331652 cites W2534694778 @default.
• W4213331652 cites W2556575619 @default.
• W4213331652 cites W2563525476 @default.
• W4213331652 cites W2618655379 @default.
• W4213331652 cites W2619368357 @default.
• W4213331652 cites W2751702930 @default.
• W4213331652 cites W2763042654 @default.
• W4213331652 cites W2793349369 @default.
• W4213331652 cites W2793359586 @default.
• W4213331652 cites W2798809372 @default.
• W4213331652 cites W2900655534 @default.
• W4213331652 cites W2903899730 @default.
• W4213331652 cites W2945739890 @default.
• W4213331652 cites W2950451781 @default.
• W4213331652 cites W2979487934 @default.
• W4213331652 cites W2982062700 @default.
• W4213331652 cites W2991378064 @default.
• W4213331652 cites W2991671000 @default.
• W4213331652 cites W2999105079 @default.
• W4213331652 cites W3001118548 @default.
• W4213331652 cites W3003217347 @default.
• W4213331652 cites W3003639008 @default.
• W4213331652 cites W3004280078 @default.
• W4213331652 cites W3004896487 @default.
• W4213331652 cites W3011049299 @default.
• W4213331652 cites W3011119456 @default.
• W4213331652 cites W3016048690 @default.
• W4213331652 cites W3016072893 @default.
• W4213331652 cites W3032936813 @default.

• next