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- W4213333721 abstract "Abstract There is considerable interest in the development of libraries of non‐peptidic macrocycles as a source of ligands for difficult targets. We report here the solid‐phase synthesis of a DNA‐encoded library of several hundred thousand thioether‐linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N−H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind Streptavidin, a model target, with high affinity." @default.
- W4213333721 created "2022-02-24" @default.
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- W4213333721 date "2022-03-02" @default.
- W4213333721 modified "2023-10-18" @default.
- W4213333721 title "Synthesis and Screening of a DNA‐Encoded Library of Non‐Peptidic Macrocycles**" @default.
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- W4213333721 doi "https://doi.org/10.1002/anie.202116999" @default.
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