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- W4213335288 abstract "Coronary artery disease (CAD), which is the manifestation of atherosclerosis in coronary arteries, is the most common single cause of death and is responsible for disabilities of millions of people worldwide. Despite numerous dedicated clinical studies and an enormous effort to develop diagnostic and therapeutic methods, coronary atherosclerosis remains one of the most serious medical problems of the modern world. Hence, new markers are still being sought to identify and manage CAD optimally. Trying to face this problem, we have raised the question of the most predominant gastrointestinal hormones; glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), mainly involved in carbohydrates disorders, could be also used as new markers of incidence, clinical course, and recurrence of CAD and are related to extent and severity of atherosclerosis and myocardial ischemia. We describe GIP and GLP-1 as expressed in many animal and human tissues, known to be connected to inflammation and related to enormous noncardiac and cardiovascular (CV) diseases. In animals, GIP and GLP-1 improve endothelial function and lead to reduced atherosclerotic plaque macrophage infiltration and stabilize atherosclerotic lesions by directly blocking monocyte migration. Moreover, in humans, GIPR activation induces the pro-atherosclerotic factors ET-1 (endothelin-1) and OPN (osteopontin) but also has anti-atherosclerotic effects through secretion of NO (nitric oxide). Furthermore, four large clinical trials showed a significant reduction in composite of CV death, MI, and stroke in long-term follow-up using GLP-1 analogs for DM 2 patients: liraglutide in LEADER, semaglutide in SUSTAIN-6, dulaglutide in REWIND and albiglutide in HARMONY. However, very little is known about GIP metabolism in the acute phase of myocardial ischemia or for stable patients with CAD, which constitutes a direction for future research. This review aims to comprehensively discuss the impact of GIP and GLP-1 on atherosclerosis and CAD and its potential therapeutic implications." @default.
- W4213335288 created "2022-02-24" @default.
- W4213335288 creator A5005371696 @default.
- W4213335288 creator A5008130178 @default.
- W4213335288 creator A5054953670 @default.
- W4213335288 creator A5059132544 @default.
- W4213335288 creator A5089620830 @default.
- W4213335288 date "2022-02-11" @default.
- W4213335288 modified "2023-10-18" @default.
- W4213335288 title "Gastrointestinal Incretins—Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-like Peptide-1 (GLP-1) beyond Pleiotropic Physiological Effects Are Involved in Pathophysiology of Atherosclerosis and Coronary Artery Disease—State of the Art" @default.
- W4213335288 cites W1507910610 @default.
- W4213335288 cites W1584635729 @default.
- W4213335288 cites W1963975889 @default.
- W4213335288 cites W1968315455 @default.
- W4213335288 cites W1969480413 @default.
- W4213335288 cites W1969932276 @default.
- W4213335288 cites W1973901069 @default.
- W4213335288 cites W1977009119 @default.
- W4213335288 cites W1980561124 @default.
- W4213335288 cites W1980605472 @default.
- W4213335288 cites W1982526723 @default.
- W4213335288 cites W1984657050 @default.
- W4213335288 cites W1986968926 @default.
- W4213335288 cites W1987682044 @default.
- W4213335288 cites W1996669620 @default.
- W4213335288 cites W1997505976 @default.
- W4213335288 cites W2004021898 @default.
- W4213335288 cites W2006841717 @default.
- W4213335288 cites W2013082477 @default.
- W4213335288 cites W2016394052 @default.
- W4213335288 cites W2016632734 @default.
- W4213335288 cites W2016896327 @default.
- W4213335288 cites W2020603363 @default.
- W4213335288 cites W2033892901 @default.
- W4213335288 cites W2039827979 @default.
- W4213335288 cites W2051298109 @default.
- W4213335288 cites W2051373862 @default.
- W4213335288 cites W2055611619 @default.
- W4213335288 cites W2059838070 @default.
- W4213335288 cites W2074956966 @default.
- W4213335288 cites W2075567076 @default.
- W4213335288 cites W2080103614 @default.
- W4213335288 cites W2080959651 @default.
- W4213335288 cites W2082213840 @default.
- W4213335288 cites W2084948079 @default.
- W4213335288 cites W2097621088 @default.
- W4213335288 cites W2099475256 @default.
- W4213335288 cites W2102977341 @default.
- W4213335288 cites W2104818363 @default.
- W4213335288 cites W2105340388 @default.
- W4213335288 cites W2105726125 @default.
- W4213335288 cites W2106339546 @default.
- W4213335288 cites W2108282017 @default.
- W4213335288 cites W2110725041 @default.
- W4213335288 cites W2110914062 @default.
- W4213335288 cites W2111482319 @default.
- W4213335288 cites W2112912403 @default.
- W4213335288 cites W2113094401 @default.
- W4213335288 cites W2114481251 @default.
- W4213335288 cites W2115778460 @default.
- W4213335288 cites W2118987724 @default.
- W4213335288 cites W2123030262 @default.
- W4213335288 cites W2123355624 @default.
- W4213335288 cites W2124852816 @default.
- W4213335288 cites W2125364438 @default.
- W4213335288 cites W2128136193 @default.
- W4213335288 cites W2132802847 @default.
- W4213335288 cites W2134141467 @default.
- W4213335288 cites W2134760433 @default.
- W4213335288 cites W2135617148 @default.
- W4213335288 cites W2140978079 @default.
- W4213335288 cites W2142097676 @default.
- W4213335288 cites W2145781698 @default.
- W4213335288 cites W2148850438 @default.
- W4213335288 cites W2149137804 @default.
- W4213335288 cites W2149717292 @default.
- W4213335288 cites W2150959326 @default.
- W4213335288 cites W2156472431 @default.
- W4213335288 cites W2158945113 @default.
- W4213335288 cites W2159205789 @default.
- W4213335288 cites W2163660677 @default.
- W4213335288 cites W2164961795 @default.
- W4213335288 cites W2261184724 @default.
- W4213335288 cites W2282578582 @default.
- W4213335288 cites W2301526740 @default.
- W4213335288 cites W2305885852 @default.
- W4213335288 cites W2313095080 @default.
- W4213335288 cites W2336931002 @default.
- W4213335288 cites W2416388175 @default.
- W4213335288 cites W2425644022 @default.
- W4213335288 cites W2519510391 @default.
- W4213335288 cites W2554729258 @default.
- W4213335288 cites W2738105512 @default.
- W4213335288 cites W2754041380 @default.
- W4213335288 cites W2770664083 @default.
- W4213335288 cites W2773969925 @default.
- W4213335288 cites W2777592053 @default.
- W4213335288 cites W2804558913 @default.