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- W4213366931 abstract "The exocyst is an octameric complex required for polarized secretion. Some components of the exocyst are found on the plasma membrane, whereas others are recruited to Golgi membranes, suggesting that exocyst assembly tethers vesicles to their site of fusion. We have found that in Drosophila melanogaster oocytes the majority of the exocyst component Sec5 is unexpectedly present in clathrin-coated pits and vesicles at the plasma membrane. In oocytes, the major substrate for clathrin-dependent endocytosis is the vitellogenin receptor Yolkless. A truncation mutant of Sec5 (sec5(E13)) allows the formation of normally sized oocytes but with greatly reduced yolk uptake. We find that in sec5(E13) oocytes Yolkless accumulates aberrantly in late endocytic compartments, indicating a defect in the endocytic cycling of the receptor. An analogous truncation of the yeast SEC5 gene results in normal secretion but a temperature-sensitive defect in endocytic recycling. Thus, the exocyst may act in both Golgi to plasma membrane traffic and endocytic cycling, and hence in oocytes is recruited to clathrin-coated pits to facilitate the rapid recycling of Yolkless. PMID: 15955846" @default.
- W4213366931 created "2022-02-24" @default.
- W4213366931 creator A5077563393 @default.
- W4213366931 date "2005-07-22" @default.
- W4213366931 modified "2023-10-06" @default.
- W4213366931 title "Faculty Opinions recommendation of The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster." @default.
- W4213366931 doi "https://doi.org/10.3410/f.1027016.327510" @default.
- W4213366931 hasPublicationYear "2005" @default.
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