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- W4213374294 abstract "A new flavonol glycoside derivate named kaempferol 3- O- trans- p-coumaroyl-7- O- α-ʟ-rhamnoside (1), together with five known compounds (2–6), was isolated from the EtOAc-soluble extract of the leaves of Tripterygium wilfordii. The structure of new compound was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro cytotoxic activity against four human cancer cells including HepG2, Hep3B, A549 and MCF-7. Among them, compound 1 exhibited the significant cytotoxic activities against HepG2 and Hep3B cells with IC 50 values of 6.8 ± 1.6 and 4.2 ± 1.3 μM, respectively. The above data demonstrated the potential of 1 for the treatment of liver cancer. In addition, 4 also showed moderate inhibitory activity on HepG2 and Hep3B cells with IC 50 values of 16.1 ± 2.3 and 10.7 ± 1.8 μM, respectively." @default.
- W4213374294 created "2022-02-24" @default.
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- W4213374294 date "2022-01-01" @default.
- W4213374294 modified "2023-10-18" @default.
- W4213374294 title "Chemical constituents from the leaves of Tripterygium wilfordii and their cytotoxic activity" @default.
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- W4213374294 doi "https://doi.org/10.1177/17475198211062836" @default.
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