FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213375776> ?p ?o ?g. }

• W4213375776 endingPage "3777" @default.
• W4213375776 startingPage "3754" @default.
• W4213375776 abstract "Anticonvulsants targeting K+ channels have not been clinically available, although neuronal hyperexcitability in seizures could be suppressed by activation of K+ channels. Voltage-gated A-type K+ channel (A-channel) inhibitors may be prescribed for diseases of neuromuscular junction but could cause seizures. Consistently, genetic loss of function of A-channels may also cause seizures. It is unclear why inhibition of A-channels, compared with other types of K+ channels, is particularly prone to seizure induction. This hinders the development of relevant therapeutic interventions.Mechanisms underlying epileptogenesis with A-channel inhibition and antiepileptic actions of A-channel activation were investigated with electrophysiological, pharmacological, optogenetic, and behavioral approaches.Pre-synaptic KV 1.4 and post-synaptic KV 4.3 A-channels act synergistically to gate glutamatergic transmission and control rhythmogenesis in the amygdala. The interconnected neurons set into the oscillatory mode by A-channel inhibition would reverberate with regular paces and the same top frequency, demonstrating a spatio-temporally well-orchestrated system with built-in oscillatory rhythms normally curbed by A-channels. Accordingly, selective over-excitation of glutamatergic neurons or inhibition of A-channels can induce behavioural seizures, which may be ameliorated by A-channel activators (e.g. NS-5806) or AMPA receptor antagonists (e.g. perampanel).Trans-synaptic voltage-dependent A-channels serve as a biophysical-biochemical transducer responsible for a novel form of synaptic plasticity. Such a network-level switch into and out of the oscillatory mode may underlie a wide scope of telencephalic information processing or, at its extreme, epileptic seizures. A-channels thus constitute a potential target of antiepileptic therapy." @default.
• W4213375776 created "2022-02-24" @default.
• W4213375776 creator A5025269482 @default.
• W4213375776 creator A5064209678 @default.
• W4213375776 creator A5067463471 @default.
• W4213375776 creator A5069704071 @default.
• W4213375776 creator A5071289172 @default.
• W4213375776 creator A5080946525 @default.
• W4213375776 date "2022-03-15" @default.
• W4213375776 modified "2023-10-14" @default.
• W4213375776 title "Pre‐synaptic and post‐synaptic A‐type K ⁺ channels regulate glutamatergic transmission and switching of the network into epileptiform oscillations" @default.
• W4213375776 cites W106141043 @default.
• W4213375776 cites W1455455345 @default.
• W4213375776 cites W1524865348 @default.
• W4213375776 cites W1549050411 @default.
• W4213375776 cites W1960266861 @default.
• W4213375776 cites W1962445436 @default.
• W4213375776 cites W1971505882 @default.
• W4213375776 cites W1973869894 @default.
• W4213375776 cites W1977013974 @default.
• W4213375776 cites W1977640234 @default.
• W4213375776 cites W1980480824 @default.
• W4213375776 cites W1981271645 @default.
• W4213375776 cites W1982817117 @default.
• W4213375776 cites W1983128504 @default.
• W4213375776 cites W1986756108 @default.
• W4213375776 cites W1991099788 @default.
• W4213375776 cites W1992169094 @default.
• W4213375776 cites W1992733772 @default.
• W4213375776 cites W1993373176 @default.
• W4213375776 cites W1994308963 @default.
• W4213375776 cites W2000341627 @default.
• W4213375776 cites W2016000829 @default.
• W4213375776 cites W2017647151 @default.
• W4213375776 cites W2020794407 @default.
• W4213375776 cites W2022608470 @default.
• W4213375776 cites W2024727214 @default.
• W4213375776 cites W2028226828 @default.
• W4213375776 cites W2034132958 @default.
• W4213375776 cites W2042431572 @default.
• W4213375776 cites W2044818530 @default.
• W4213375776 cites W2046150309 @default.
• W4213375776 cites W2048484812 @default.
• W4213375776 cites W2049859818 @default.
• W4213375776 cites W2054776784 @default.
• W4213375776 cites W2054879572 @default.
• W4213375776 cites W2058648733 @default.
• W4213375776 cites W2070011714 @default.
• W4213375776 cites W2072788377 @default.
• W4213375776 cites W2075312117 @default.
• W4213375776 cites W2079173805 @default.
• W4213375776 cites W2080737400 @default.
• W4213375776 cites W2081428705 @default.
• W4213375776 cites W2083932518 @default.
• W4213375776 cites W2083974405 @default.
• W4213375776 cites W2086387632 @default.
• W4213375776 cites W2092734837 @default.
• W4213375776 cites W2093238337 @default.
• W4213375776 cites W2094106472 @default.
• W4213375776 cites W2094330710 @default.
• W4213375776 cites W2094529776 @default.
• W4213375776 cites W2096066777 @default.
• W4213375776 cites W2097480079 @default.
• W4213375776 cites W2099587101 @default.
• W4213375776 cites W2099925060 @default.
• W4213375776 cites W2102994933 @default.
• W4213375776 cites W2103946141 @default.
• W4213375776 cites W2112196515 @default.
• W4213375776 cites W2112927743 @default.
• W4213375776 cites W2117039110 @default.
• W4213375776 cites W2117419605 @default.
• W4213375776 cites W2127109018 @default.
• W4213375776 cites W2127296441 @default.
• W4213375776 cites W2142875089 @default.
• W4213375776 cites W2143470172 @default.
• W4213375776 cites W2147381068 @default.
• W4213375776 cites W2149303478 @default.
• W4213375776 cites W2163863321 @default.
• W4213375776 cites W2168858520 @default.
• W4213375776 cites W2168941271 @default.
• W4213375776 cites W2285774466 @default.
• W4213375776 cites W2332249202 @default.
• W4213375776 cites W2410772780 @default.
• W4213375776 cites W2462101369 @default.
• W4213375776 cites W2592696179 @default.
• W4213375776 cites W2727602676 @default.
• W4213375776 cites W2762958751 @default.
• W4213375776 cites W2789702885 @default.
• W4213375776 cites W2791419854 @default.
• W4213375776 cites W2885426480 @default.
• W4213375776 cites W2924912121 @default.
• W4213375776 cites W2972287915 @default.
• W4213375776 cites W2982803386 @default.
• W4213375776 cites W3007271284 @default.
• W4213375776 cites W3010654069 @default.
• W4213375776 cites W3042519295 @default.
• W4213375776 cites W3083801165 @default.
• W4213375776 cites W3092180082 @default.

• next