Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213387807> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4213387807 endingPage "324" @default.
- W4213387807 startingPage "323" @default.
- W4213387807 abstract "Rates of hydrolysis of racemic and enantiomeric lorazepam 3-acetates (LZA) by esterases in human and rat liver microsomes and rat brain S9 fraction were compared. LZA and its hydrolysis product were analyzed by chiral stationary phase HPLC. When rac-LZA was the substrate, the (R)-LZA was hydrolyzed 2.7-fold and 6.8-fold faster than the (S)-LZA by esterases in rat and human liver microsomes, respectively. In contrast, esterases in rat brain S9 fraction were enantioselective toward the (S)-LZA. The specific activities (nmol of LZA hydrolyzed/mg protein/min) of liver microsomes in the hydrolysis of enantiomerically pure (R)-LZA were approximately 210 (rat) and 1330 (human), and in the hydrolysis of enantiomerically pure (S)-LZA were 25 (rat) and 8 (human). The specific activities of rat brain S9 fraction in the hydrolysis of enantiomerically pure (R)-LZA and (S)-LZA were approximately 3 and 6 nmol/mg protein/min, respectively. Results also indicated an enantiomeric interaction in the hydrolysis of rac-LZA; the presence of (R)-LZA stimulated the hydrolysis of (S)-LZA by all esterase preparations, whereas the presence of (S)-LZA stimulated the hydrolysis of (R)-LZA in rat brain S9 fraction and inhibited the hydrolysis of (R)-LZA in rat and human liver microsomes." @default.
- W4213387807 created "2022-02-24" @default.
- W4213387807 creator A5042190848 @default.
- W4213387807 creator A5062732706 @default.
- W4213387807 date "1990-06-01" @default.
- W4213387807 modified "2023-10-16" @default.
- W4213387807 title "Restrictive cardiomyopathy." @default.
- W4213387807 cites W1480950303 @default.
- W4213387807 cites W1487665482 @default.
- W4213387807 cites W1491965987 @default.
- W4213387807 cites W1566263355 @default.
- W4213387807 cites W1575257760 @default.
- W4213387807 cites W1967414280 @default.
- W4213387807 cites W1968084103 @default.
- W4213387807 cites W1969360543 @default.
- W4213387807 cites W1972901673 @default.
- W4213387807 cites W1978800575 @default.
- W4213387807 cites W2008215819 @default.
- W4213387807 cites W2010332852 @default.
- W4213387807 cites W2012044731 @default.
- W4213387807 cites W2018523345 @default.
- W4213387807 cites W2019307732 @default.
- W4213387807 cites W2033274261 @default.
- W4213387807 cites W2040759703 @default.
- W4213387807 cites W2049898224 @default.
- W4213387807 cites W2083661791 @default.
- W4213387807 cites W2084571556 @default.
- W4213387807 cites W2116067121 @default.
- W4213387807 cites W2117374911 @default.
- W4213387807 cites W2118942953 @default.
- W4213387807 cites W2149900394 @default.
- W4213387807 cites W2235071665 @default.
- W4213387807 cites W2340271788 @default.
- W4213387807 cites W2588675459 @default.
- W4213387807 cites W39461475 @default.
- W4213387807 cites W4235444669 @default.
- W4213387807 cites W4252772420 @default.
- W4213387807 doi "https://doi.org/10.1136/hrt.63.6.323" @default.
- W4213387807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2198068" @default.
- W4213387807 hasPublicationYear "1990" @default.
- W4213387807 type Work @default.
- W4213387807 citedByCount "14" @default.
- W4213387807 countsByYear W42133878072012 @default.
- W4213387807 countsByYear W42133878072014 @default.
- W4213387807 crossrefType "journal-article" @default.
- W4213387807 hasAuthorship W4213387807A5042190848 @default.
- W4213387807 hasAuthorship W4213387807A5062732706 @default.
- W4213387807 hasBestOaLocation W42133878071 @default.
- W4213387807 hasConcept C179998833 @default.
- W4213387807 hasConcept C181199279 @default.
- W4213387807 hasConcept C185592680 @default.
- W4213387807 hasConcept C2776678776 @default.
- W4213387807 hasConcept C2777261171 @default.
- W4213387807 hasConcept C43617362 @default.
- W4213387807 hasConcept C486523 @default.
- W4213387807 hasConcept C55493867 @default.
- W4213387807 hasConcept C62231903 @default.
- W4213387807 hasConcept C71240020 @default.
- W4213387807 hasConcept C71924100 @default.
- W4213387807 hasConcept C87644729 @default.
- W4213387807 hasConcept C94412978 @default.
- W4213387807 hasConceptScore W4213387807C179998833 @default.
- W4213387807 hasConceptScore W4213387807C181199279 @default.
- W4213387807 hasConceptScore W4213387807C185592680 @default.
- W4213387807 hasConceptScore W4213387807C2776678776 @default.
- W4213387807 hasConceptScore W4213387807C2777261171 @default.
- W4213387807 hasConceptScore W4213387807C43617362 @default.
- W4213387807 hasConceptScore W4213387807C486523 @default.
- W4213387807 hasConceptScore W4213387807C55493867 @default.
- W4213387807 hasConceptScore W4213387807C62231903 @default.
- W4213387807 hasConceptScore W4213387807C71240020 @default.
- W4213387807 hasConceptScore W4213387807C71924100 @default.
- W4213387807 hasConceptScore W4213387807C87644729 @default.
- W4213387807 hasConceptScore W4213387807C94412978 @default.
- W4213387807 hasIssue "6" @default.
- W4213387807 hasLocation W42133878071 @default.
- W4213387807 hasLocation W42133878072 @default.
- W4213387807 hasLocation W42133878073 @default.
- W4213387807 hasOpenAccess W4213387807 @default.
- W4213387807 hasPrimaryLocation W42133878071 @default.
- W4213387807 hasRelatedWork W2021792606 @default.
- W4213387807 hasRelatedWork W2036826355 @default.
- W4213387807 hasRelatedWork W2073086059 @default.
- W4213387807 hasRelatedWork W2081368264 @default.
- W4213387807 hasRelatedWork W2148830609 @default.
- W4213387807 hasRelatedWork W2166263961 @default.
- W4213387807 hasRelatedWork W2196125403 @default.
- W4213387807 hasRelatedWork W2371841285 @default.
- W4213387807 hasRelatedWork W2400241202 @default.
- W4213387807 hasRelatedWork W4213387807 @default.
- W4213387807 hasVolume "63" @default.
- W4213387807 isParatext "false" @default.
- W4213387807 isRetracted "false" @default.
- W4213387807 workType "article" @default.