FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213411949> ?p ?o ?g. }

• W4213411949 endingPage "13" @default.
• W4213411949 startingPage "1" @default.
• W4213411949 abstract "PTEN mutations have been reported to be involved in the development and prognosis of endometrial carcinoma (EC). However, a prognostic gene signature associated with PTEN mutational status has not yet been developed. In this study, we generated a PTEN mutation-associated prognostic gene signature for EC.We obtained the single-nucleotide variation and transcriptomic profiling data from The Cancer Genome Atlas database as training data and implemented the least absolute shrinkage and selection operator (LASSO) Cox regression algorithm to establish a PTEN mutation-associated prognostic gene signature. The overall survival rates of the high-risk and low-risk groups were determined with the Kaplan-Meier (K-M) method, and the accuracy of risk score prediction was tested by using the receiver operating characteristic (ROC) curve.The K-M curves revealed that the EC patients with PTEN mutations augured favorable survival outcomes. Differential expression analysis between the EC patients with PTEN mutation and wild-type PTEN identified 224 differentially expressed genes (DEGs). Eighty-four DEGs that manifested prognostic value were fitted into the LASSO-Cox analysis, and a PTEN gene signature with seven mutation-associated prognostic genes that showed robust prognostic ability was constructed; this signature was then successfully validated in the other two datasets from the cBioPortal database as well as with 60 clinical specimens. Furthermore, the PTEN mutation-associated prognostic gene signature proved to be an independent prognostic predictor of EC. Remarkably, the EC patients in the high-risk group were characterized by higher tumor stages and grades as well as lower tumor mutation burden with respect to EC, with a poor survival outcome. Collectively, the PTEN mutation-associated prognostic gene signature that we developed could now be used as a favorable prognostic biomarker for EC.In summary, we developed and validated a prognostic predictor for EC associated with PTEN mutational status that may be used as a favorable prognostic biomarker and therapeutic target for EC." @default.
• W4213411949 created "2022-02-25" @default.
• W4213411949 creator A5018324670 @default.
• W4213411949 creator A5053260505 @default.
• W4213411949 creator A5057417537 @default.
• W4213411949 creator A5067147365 @default.
• W4213411949 date "2022-02-23" @default.
• W4213411949 modified "2023-09-25" @default.
• W4213411949 title "Significance of a PTEN Mutational Status-Associated Gene Signature in the Progression and Prognosis of Endometrial Carcinoma" @default.
• W4213411949 cites W122284785 @default.
• W4213411949 cites W1905261809 @default.
• W4213411949 cites W1911329982 @default.
• W4213411949 cites W1919614031 @default.
• W4213411949 cites W1997490786 @default.
• W4213411949 cites W2010784970 @default.
• W4213411949 cites W2047942060 @default.
• W4213411949 cites W2054966143 @default.
• W4213411949 cites W2096334610 @default.
• W4213411949 cites W2115156634 @default.
• W4213411949 cites W2136469817 @default.
• W4213411949 cites W2136602069 @default.
• W4213411949 cites W2145826166 @default.
• W4213411949 cites W2170665660 @default.
• W4213411949 cites W2190856209 @default.
• W4213411949 cites W2223504426 @default.
• W4213411949 cites W2302301703 @default.
• W4213411949 cites W2315463434 @default.
• W4213411949 cites W2337494975 @default.
• W4213411949 cites W2373633447 @default.
• W4213411949 cites W2473214092 @default.
• W4213411949 cites W2509437530 @default.
• W4213411949 cites W2597687928 @default.
• W4213411949 cites W2762665899 @default.
• W4213411949 cites W2766128321 @default.
• W4213411949 cites W2904334146 @default.
• W4213411949 cites W2906313208 @default.
• W4213411949 cites W2908096907 @default.
• W4213411949 cites W2922057878 @default.
• W4213411949 cites W2968122977 @default.
• W4213411949 cites W2978216081 @default.
• W4213411949 cites W2982414086 @default.
• W4213411949 cites W2990068156 @default.
• W4213411949 cites W3000779027 @default.
• W4213411949 cites W3013465711 @default.
• W4213411949 cites W3014064455 @default.
• W4213411949 cites W3034875697 @default.
• W4213411949 cites W3035809804 @default.
• W4213411949 cites W3036777911 @default.
• W4213411949 cites W3039536862 @default.
• W4213411949 cites W3046987317 @default.
• W4213411949 cites W3085742989 @default.
• W4213411949 cites W3096270535 @default.
• W4213411949 cites W3099766406 @default.
• W4213411949 cites W3114467836 @default.
• W4213411949 cites W3132683379 @default.
• W4213411949 cites W3164166155 @default.
• W4213411949 cites W3164723138 @default.
• W4213411949 cites W3189465034 @default.
• W4213411949 cites W37089595 @default.
• W4213411949 cites W4241479729 @default.
• W4213411949 doi "https://doi.org/10.1155/2022/5130648" @default.
• W4213411949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35251475" @default.
• W4213411949 hasPublicationYear "2022" @default.
• W4213411949 type Work @default.
• W4213411949 citedByCount "1" @default.
• W4213411949 countsByYear W42134119492022 @default.
• W4213411949 crossrefType "journal-article" @default.
• W4213411949 hasAuthorship W4213411949A5018324670 @default.
• W4213411949 hasAuthorship W4213411949A5053260505 @default.
• W4213411949 hasAuthorship W4213411949A5057417537 @default.
• W4213411949 hasAuthorship W4213411949A5067147365 @default.
• W4213411949 hasBestOaLocation W42134119491 @default.
• W4213411949 hasConcept C104317684 @default.
• W4213411949 hasConcept C10515644 @default.
• W4213411949 hasConcept C121608353 @default.
• W4213411949 hasConcept C126322002 @default.
• W4213411949 hasConcept C143998085 @default.
• W4213411949 hasConcept C190283241 @default.
• W4213411949 hasConcept C2777088508 @default.
• W4213411949 hasConcept C2777609662 @default.
• W4213411949 hasConcept C501734568 @default.
• W4213411949 hasConcept C502942594 @default.
• W4213411949 hasConcept C50382708 @default.
• W4213411949 hasConcept C54355233 @default.
• W4213411949 hasConcept C58471807 @default.
• W4213411949 hasConcept C71924100 @default.
• W4213411949 hasConcept C86554907 @default.
• W4213411949 hasConcept C86803240 @default.
• W4213411949 hasConceptScore W4213411949C104317684 @default.
• W4213411949 hasConceptScore W4213411949C10515644 @default.
• W4213411949 hasConceptScore W4213411949C121608353 @default.
• W4213411949 hasConceptScore W4213411949C126322002 @default.
• W4213411949 hasConceptScore W4213411949C143998085 @default.
• W4213411949 hasConceptScore W4213411949C190283241 @default.
• W4213411949 hasConceptScore W4213411949C2777088508 @default.
• W4213411949 hasConceptScore W4213411949C2777609662 @default.
• W4213411949 hasConceptScore W4213411949C501734568 @default.
• W4213411949 hasConceptScore W4213411949C502942594 @default.

• next