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• W4213415572 abstract "Abstract Background: Acute respiratory distress syndrome (ARDS) is a heterogeneous disease with extremely high mortality. We hypothesized that the serum β2-microglobulin (β2MG) level would be elevated and be an independent risk factor for 28-day mortality in patients with ARDS caused by bacterial infection. Methods: We retrospectively enrolled 257 patients with ARDS caused by bacterial infection from January 1, 2015 to February 28, 2021. Patients were followed for up to 28 days and were divided into a survival group and non-survival group according to their clinical outcomes. The serum β2MG levels and other clinical data were collected. The relationship between β2MG levels and 28-day mortality was explored by performing a Cox regression analysis adjusted for age, updated Charlson comorbidity index, disorders of consciousness, septic shock, albumin level, cardiac troponin I level, procalcitonin level, lactic acid level, prothrombin time, partial pressure of arterial oxygen/fraction of inspired oxygen ratio, creatinine clearance rate, acute kidney injury and Sequential Organ Failure Assessment. Results: In this cohort, 96 patients died in 28 days, yielding a 28-day mortality of 37.4%. The median level of serum β2MG for all enrolled patients was 4.7 (interquartile range [IQR]:2.9 - 8.5) mg/L. Higher β2MG levels were significantly associated with 28-day mortality when the β2MG level was analysed as a continuous variable (hazard ratio [HR]: 1.054; 95% confidence interval [CI]:1.005 - 1.105; P = 0.031) and when it was categorized into tertiles (HR: 3.239; 95% CI: 1.177 - 8.913; P = 0.023). The β2MG level exhibited a high diagnostic accuracy for predicting 28-day mortality (area under the curve [AUC] = 0.732; 95% CI:0.673-0.785; sensitivity:74.0%; specificity:64.0%; P <0.001). Conclusions: The level of serum β2MG is elevated and is an independent risk factor of 28-day mortality in patients with ARDS caused by bacterial infection." @default.
• W4213415572 created "2022-02-25" @default.
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• W4213415572 date "2022-02-23" @default.
• W4213415572 modified "2023-09-27" @default.
• W4213415572 title "Serum β2‑microglobulin: An independent risk factor for mortality in patients with acute respiratory distress syndrome caused by bacterial infection" @default.
• W4213415572 doi "https://doi.org/10.21203/rs.3.rs-1354267/v1" @default.
• W4213415572 hasPublicationYear "2022" @default.
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