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- W4213416115 abstract "Within certain cancers, extensive copy number alterations (CNAs) contribute to a complex and heterogenic genomic profile. This makes it difficult to understand and unravel the distinct molecular dynamics shaping the disease while preventing clinically effective patient stratification. CNA signature analysis represents a novel genomic stratification tool for probing this complexity, offering an intricate framework for deriving CNA patterns at the molecular level. This allows the underlying genomic mechanisms of specific cancers to be revealed, leading to the potential identification of therapeutic targets and prognostic associations. This review outlines the molecular and methodological basis of CNA signatures and focuses on recent advances highlighting their clinical utility, limitations and prospective future as novel diagnostic and prognostic cancer biomarkers." @default.
- W4213416115 created "2022-02-25" @default.
- W4213416115 creator A5054787498 @default.
- W4213416115 creator A5074326062 @default.
- W4213416115 date "2022-04-01" @default.
- W4213416115 modified "2023-09-25" @default.
- W4213416115 title "Copy number alteration signatures as biomarkers in cancer: a review" @default.
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- W4213416115 doi "https://doi.org/10.2217/bmm-2021-0476" @default.
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- W4213416115 hasPublicationYear "2022" @default.
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