Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213426117> ?p ?o ?g. }
- W4213426117 endingPage "370" @default.
- W4213426117 startingPage "360" @default.
- W4213426117 abstract "Host genetic and environmental factors including age, biological sex, diet, geographical location, microbiome composition and metabolites converge to influence innate and adaptive immune responses to vaccines. Failure to understand and account for these factors when investigating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine efficacy may impair the development of the next generation of vaccines. Most studies aimed at identifying mechanisms of vaccine-mediated immune protection have focused on adaptive immune responses. It is well established, however, that mobilization of the innate immune response is essential to the development of effective cellular and humoral immunity. A comprehensive understanding of the innate immune response and environmental factors that contribute to the development of broad and durable cellular and humoral immune responses to SARS-CoV-2 and other vaccines requires a holistic and unbiased approach. Along with optimization of the immunogen and vectors, the development of adjuvants based on our evolving understanding of how the innate immune system shapes vaccine responses will be essential. Defining the innate immune mechanisms underlying the establishment of long-lived plasma cells and memory T cells could lead to a universal vaccine for coronaviruses, a key biomedical priority." @default.
- W4213426117 created "2022-02-25" @default.
- W4213426117 creator A5025067591 @default.
- W4213426117 creator A5031713882 @default.
- W4213426117 creator A5040099496 @default.
- W4213426117 creator A5041834561 @default.
- W4213426117 date "2022-02-24" @default.
- W4213426117 modified "2023-10-18" @default.
- W4213426117 title "Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses" @default.
- W4213426117 cites W1555063324 @default.
- W4213426117 cites W1565300738 @default.
- W4213426117 cites W1839272823 @default.
- W4213426117 cites W1979991507 @default.
- W4213426117 cites W1984110560 @default.
- W4213426117 cites W1987480613 @default.
- W4213426117 cites W1990295999 @default.
- W4213426117 cites W1998100955 @default.
- W4213426117 cites W1999324987 @default.
- W4213426117 cites W1999906527 @default.
- W4213426117 cites W2004445541 @default.
- W4213426117 cites W2025273503 @default.
- W4213426117 cites W2030284768 @default.
- W4213426117 cites W2030310775 @default.
- W4213426117 cites W2034484954 @default.
- W4213426117 cites W2042045439 @default.
- W4213426117 cites W2043149070 @default.
- W4213426117 cites W2066586758 @default.
- W4213426117 cites W2068679052 @default.
- W4213426117 cites W2071360012 @default.
- W4213426117 cites W2087442320 @default.
- W4213426117 cites W2097670917 @default.
- W4213426117 cites W2100357356 @default.
- W4213426117 cites W2104910525 @default.
- W4213426117 cites W2106008384 @default.
- W4213426117 cites W2108105410 @default.
- W4213426117 cites W2111838412 @default.
- W4213426117 cites W2119522619 @default.
- W4213426117 cites W2121263559 @default.
- W4213426117 cites W2122206758 @default.
- W4213426117 cites W2124172324 @default.
- W4213426117 cites W2126020016 @default.
- W4213426117 cites W2130351191 @default.
- W4213426117 cites W2134167421 @default.
- W4213426117 cites W2149010238 @default.
- W4213426117 cites W2162704444 @default.
- W4213426117 cites W2164722422 @default.
- W4213426117 cites W2169415889 @default.
- W4213426117 cites W2229921221 @default.
- W4213426117 cites W2604753146 @default.
- W4213426117 cites W2605882082 @default.
- W4213426117 cites W2613240323 @default.
- W4213426117 cites W2620571768 @default.
- W4213426117 cites W2624476313 @default.
- W4213426117 cites W2755772860 @default.
- W4213426117 cites W2761732668 @default.
- W4213426117 cites W2782708334 @default.
- W4213426117 cites W2783642412 @default.
- W4213426117 cites W2786985471 @default.
- W4213426117 cites W2793411374 @default.
- W4213426117 cites W2844364183 @default.
- W4213426117 cites W2887314767 @default.
- W4213426117 cites W2889133269 @default.
- W4213426117 cites W2897063882 @default.
- W4213426117 cites W2945873179 @default.
- W4213426117 cites W2971999614 @default.
- W4213426117 cites W2988699324 @default.
- W4213426117 cites W2995308611 @default.
- W4213426117 cites W2995350619 @default.
- W4213426117 cites W3009920944 @default.
- W4213426117 cites W3011219969 @default.
- W4213426117 cites W3033126715 @default.
- W4213426117 cites W3038672629 @default.
- W4213426117 cites W3048464370 @default.
- W4213426117 cites W3081762391 @default.
- W4213426117 cites W3083287531 @default.
- W4213426117 cites W3088203083 @default.
- W4213426117 cites W3092016255 @default.
- W4213426117 cites W3092766467 @default.
- W4213426117 cites W3092870352 @default.
- W4213426117 cites W3100724954 @default.
- W4213426117 cites W3101006877 @default.
- W4213426117 cites W3102328262 @default.
- W4213426117 cites W3106739077 @default.
- W4213426117 cites W3111255098 @default.
- W4213426117 cites W3111590711 @default.
- W4213426117 cites W3112419967 @default.
- W4213426117 cites W3119002128 @default.
- W4213426117 cites W3123159881 @default.
- W4213426117 cites W3125030534 @default.
- W4213426117 cites W3129166185 @default.
- W4213426117 cites W3130536572 @default.
- W4213426117 cites W3132896036 @default.
- W4213426117 cites W3133745688 @default.
- W4213426117 cites W3135463255 @default.
- W4213426117 cites W3136167624 @default.
- W4213426117 cites W3139161083 @default.
- W4213426117 cites W3139490202 @default.
- W4213426117 cites W3142193311 @default.