Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213426762> ?p ?o ?g. }
- W4213426762 abstract "Cachexia is a wasting syndrome characterized by devastating skeletal muscle atrophy that dramatically increases mortality in various diseases, most notably in cancer patients with a penetrance of up to 80%. Knowledge regarding the mechanism of cancer-induced cachexia remains very scarce, making cachexia an unmet medical need. In this study, we discovered strong alterations of iron metabolism in the skeletal muscle of both cancer patients and tumor-bearing mice, characterized by decreased iron availability in mitochondria. We found that modulation of iron levels directly influences myotube size in vitro and muscle mass in otherwise healthy mice. Furthermore, iron supplementation was sufficient to preserve both muscle function and mass, prolong survival in tumor-bearing mice, and even rescues strength in human subjects within an unexpectedly short time frame. Importantly, iron supplementation refuels mitochondrial oxidative metabolism and energy production. Overall, our findings provide new mechanistic insights in cancer-induced skeletal muscle wasting, and support targeting iron metabolism as a potential therapeutic option for muscle wasting diseases." @default.
- W4213426762 created "2022-02-25" @default.
- W4213426762 creator A5001129157 @default.
- W4213426762 creator A5005112202 @default.
- W4213426762 creator A5005606442 @default.
- W4213426762 creator A5012999907 @default.
- W4213426762 creator A5015026092 @default.
- W4213426762 creator A5028406393 @default.
- W4213426762 creator A5032548159 @default.
- W4213426762 creator A5033985207 @default.
- W4213426762 creator A5038395336 @default.
- W4213426762 creator A5043464756 @default.
- W4213426762 creator A5045008462 @default.
- W4213426762 creator A5057626276 @default.
- W4213426762 creator A5058516214 @default.
- W4213426762 creator A5060176567 @default.
- W4213426762 creator A5062671029 @default.
- W4213426762 creator A5063627178 @default.
- W4213426762 creator A5075168526 @default.
- W4213426762 creator A5078909013 @default.
- W4213426762 creator A5080487904 @default.
- W4213426762 creator A5091008483 @default.
- W4213426762 date "2022-02-24" @default.
- W4213426762 modified "2023-10-14" @default.
- W4213426762 title "Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia" @default.
- W4213426762 cites W1547146581 @default.
- W4213426762 cites W1594726832 @default.
- W4213426762 cites W1867945077 @default.
- W4213426762 cites W1911334544 @default.
- W4213426762 cites W1955539178 @default.
- W4213426762 cites W1975708365 @default.
- W4213426762 cites W1982160718 @default.
- W4213426762 cites W1992967227 @default.
- W4213426762 cites W1995039474 @default.
- W4213426762 cites W1996390826 @default.
- W4213426762 cites W2008869575 @default.
- W4213426762 cites W2015514085 @default.
- W4213426762 cites W2051961807 @default.
- W4213426762 cites W2065586977 @default.
- W4213426762 cites W2068700852 @default.
- W4213426762 cites W2073874237 @default.
- W4213426762 cites W2076226689 @default.
- W4213426762 cites W2105199683 @default.
- W4213426762 cites W2105503795 @default.
- W4213426762 cites W2114063620 @default.
- W4213426762 cites W2145280166 @default.
- W4213426762 cites W2146262621 @default.
- W4213426762 cites W2151283204 @default.
- W4213426762 cites W2153287706 @default.
- W4213426762 cites W2157846058 @default.
- W4213426762 cites W2167860376 @default.
- W4213426762 cites W2176504547 @default.
- W4213426762 cites W2234023838 @default.
- W4213426762 cites W2239175614 @default.
- W4213426762 cites W2253924460 @default.
- W4213426762 cites W2276227009 @default.
- W4213426762 cites W2279428213 @default.
- W4213426762 cites W2280237772 @default.
- W4213426762 cites W2345985540 @default.
- W4213426762 cites W2492604038 @default.
- W4213426762 cites W2597494578 @default.
- W4213426762 cites W2603542690 @default.
- W4213426762 cites W2606272480 @default.
- W4213426762 cites W2612568177 @default.
- W4213426762 cites W2617233822 @default.
- W4213426762 cites W2747686805 @default.
- W4213426762 cites W2773511078 @default.
- W4213426762 cites W2793017307 @default.
- W4213426762 cites W2793091274 @default.
- W4213426762 cites W2794080982 @default.
- W4213426762 cites W2805688506 @default.
- W4213426762 cites W2891230248 @default.
- W4213426762 cites W2902129086 @default.
- W4213426762 cites W2931280301 @default.
- W4213426762 cites W2937060859 @default.
- W4213426762 cites W2942976489 @default.
- W4213426762 cites W2999262601 @default.
- W4213426762 cites W3009717183 @default.
- W4213426762 cites W3011401671 @default.
- W4213426762 cites W3012896646 @default.
- W4213426762 cites W3022838562 @default.
- W4213426762 cites W3048146893 @default.
- W4213426762 cites W3103243932 @default.
- W4213426762 cites W3106544668 @default.
- W4213426762 cites W3112590295 @default.
- W4213426762 cites W3134658033 @default.
- W4213426762 cites W3149879311 @default.
- W4213426762 cites W3192947947 @default.
- W4213426762 cites W4213426762 @default.
- W4213426762 doi "https://doi.org/10.15252/embr.202153746" @default.
- W4213426762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35199910" @default.
- W4213426762 hasPublicationYear "2022" @default.
- W4213426762 type Work @default.
- W4213426762 citedByCount "17" @default.
- W4213426762 countsByYear W42134267622022 @default.
- W4213426762 countsByYear W42134267622023 @default.
- W4213426762 crossrefType "journal-article" @default.
- W4213426762 hasAuthorship W4213426762A5001129157 @default.
- W4213426762 hasAuthorship W4213426762A5005112202 @default.
- W4213426762 hasAuthorship W4213426762A5005606442 @default.