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• W4213429538 abstract "Leishmania, being an intelligent protozoan parasite, modulates the defensive arsenals of the host to create a favorable niche for their survival. When the intracellular parasite is encountered by the host, multimeric complexes of inflammasomes get assembled and activated, thereby leading to genesis of inflammatory response. In order to subvert host defensive strategies, Leishmania utilizes their cyclic adenosine monophosphate (cAMP) and cAMP-induced response to neutralize macrophage oxidative damage. In this chapter, we summarize our current understanding of the mechanisms of inflammasome activation in macrophages and cAMP homeostasis of the parasite, leading to parasite viability within the macrophages and establishment of infection. Furthermore, we took into account, recent progresses in translating these research areas into therapeutic strategies, aimed at combating macrophage associated diseases." @default.
• W4213429538 created "2022-02-25" @default.
• W4213429538 creator A5009647258 @default.
• W4213429538 creator A5063059286 @default.
• W4213429538 creator A5082022074 @default.
• W4213429538 date "2022-12-14" @default.
• W4213429538 modified "2023-09-30" @default.
• W4213429538 title "The Tale of Mastering Macrophage Environment through the Control of Inflammasome-Mediated Macrophage Activation and cAMP Homeostasis by the Protozoan Parasite <i>Leishmania</i>" @default.
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