FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213439354> ?p ?o ?g. }

• W4213439354 endingPage "308" @default.
• W4213439354 startingPage "300" @default.
• W4213439354 abstract "Chronic treatment of animals with morphine results in a long lasting cellular tolerance in the locus coeruleus and alters the kinase dependent desensitization of opioid and nonopioid G protein–coupled receptors (GPCRs). This study examined the development of tolerance and altered regulation of kinase activity after chronic treatment of animals with clinically relevant opioids that differ in efficacy at the <i>µ</i>-opioid receptors (MOR). In slices from oxycodone treated animals, no tolerance to opioids was observed when measuring the MOR induced increase in potassium conductance, but the G protein receptor kinase 2/3 blocker, compound 101, no longer inhibited desensitization of somatostatin (SST) receptors. Chronic fentanyl treatment induced a rightward shift in the concentration response to [Met⁵]enkephalin, but there was no change in the kinase regulation of desensitization of the SST receptor. When total phosphorylation deficient MORs that block desensitization, internalization, and tolerance were virally expressed, chronic treatment with fentanyl resulted in the altered kinase regulation of SST receptors. The results suggest that sustained opioid receptor signaling initiates the process that results in altered kinase regulation of not only opioid receptors, but also other GPCRs. This study highlights two very distinct downstream adaptive processes that are specifically regulated by an agonist dependent mechanism. <h3>SIGNIFICANCE STATEMENT</h3> Persistent signaling of MORs results in altered kinase regulation of nonopioid GPCRs after chronic treatment with morphine and oxycodone. Profound tolerance develops after chronic treatment with fentanyl without affecting kinase regulation. The homeostatic change in the kinase regulation of nonopioid GPCRs could account for the systems level in vivo development of tolerance that is seen with opioid agonists, such as morphine and oxycodone, that develop more rapidly than the tolerance induced by efficacious agonists, such as fentanyl and etorphine." @default.
• W4213439354 created "2022-02-25" @default.
• W4213439354 creator A5024206998 @default.
• W4213439354 creator A5024826389 @default.
• W4213439354 creator A5051925051 @default.
• W4213439354 creator A5052371731 @default.
• W4213439354 creator A5087479946 @default.
• W4213439354 date "2022-02-22" @default.
• W4213439354 modified "2023-09-30" @default.
• W4213439354 title "Agonist-Specific Regulation of G Protein–Coupled Receptors after Chronic Opioid Treatment" @default.
• W4213439354 cites W1492294380 @default.
• W4213439354 cites W1561275320 @default.
• W4213439354 cites W1598320815 @default.
• W4213439354 cites W1651293660 @default.
• W4213439354 cites W1927349692 @default.
• W4213439354 cites W1948374365 @default.
• W4213439354 cites W1958846253 @default.
• W4213439354 cites W1970375683 @default.
• W4213439354 cites W1974654730 @default.
• W4213439354 cites W1978783734 @default.
• W4213439354 cites W1981304254 @default.
• W4213439354 cites W1986682253 @default.
• W4213439354 cites W1993258945 @default.
• W4213439354 cites W1994835873 @default.
• W4213439354 cites W2013510441 @default.
• W4213439354 cites W2040668587 @default.
• W4213439354 cites W2043287085 @default.
• W4213439354 cites W2051746492 @default.
• W4213439354 cites W2104412825 @default.
• W4213439354 cites W2132684873 @default.
• W4213439354 cites W2153356592 @default.
• W4213439354 cites W2161223737 @default.
• W4213439354 cites W2163072783 @default.
• W4213439354 cites W2344604487 @default.
• W4213439354 cites W2794482808 @default.
• W4213439354 cites W2889994902 @default.
• W4213439354 cites W2909204744 @default.
• W4213439354 cites W2917973990 @default.
• W4213439354 cites W2966250084 @default.
• W4213439354 cites W3011405382 @default.
• W4213439354 cites W3015123576 @default.
• W4213439354 cites W3023588038 @default.
• W4213439354 cites W3093777800 @default.
• W4213439354 cites W3181930852 @default.
• W4213439354 doi "https://doi.org/10.1124/molpharm.121.000453" @default.
• W4213439354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35193934" @default.
• W4213439354 hasPublicationYear "2022" @default.
• W4213439354 type Work @default.
• W4213439354 citedByCount "5" @default.
• W4213439354 countsByYear W42134393542022 @default.
• W4213439354 countsByYear W42134393542023 @default.
• W4213439354 crossrefType "journal-article" @default.
• W4213439354 hasAuthorship W4213439354A5024206998 @default.
• W4213439354 hasAuthorship W4213439354A5024826389 @default.
• W4213439354 hasAuthorship W4213439354A5051925051 @default.
• W4213439354 hasAuthorship W4213439354A5052371731 @default.
• W4213439354 hasAuthorship W4213439354A5087479946 @default.
• W4213439354 hasBestOaLocation W42134393541 @default.
• W4213439354 hasConcept C126322002 @default.
• W4213439354 hasConcept C135285700 @default.
• W4213439354 hasConcept C170493617 @default.
• W4213439354 hasConcept C184235292 @default.
• W4213439354 hasConcept C185592680 @default.
• W4213439354 hasConcept C201800478 @default.
• W4213439354 hasConcept C2777803847 @default.
• W4213439354 hasConcept C2778938600 @default.
• W4213439354 hasConcept C2781063702 @default.
• W4213439354 hasConcept C33235085 @default.
• W4213439354 hasConcept C71924100 @default.
• W4213439354 hasConcept C86803240 @default.
• W4213439354 hasConcept C92759361 @default.
• W4213439354 hasConcept C95444343 @default.
• W4213439354 hasConcept C98274493 @default.
• W4213439354 hasConceptScore W4213439354C126322002 @default.
• W4213439354 hasConceptScore W4213439354C135285700 @default.
• W4213439354 hasConceptScore W4213439354C170493617 @default.
• W4213439354 hasConceptScore W4213439354C184235292 @default.
• W4213439354 hasConceptScore W4213439354C185592680 @default.
• W4213439354 hasConceptScore W4213439354C201800478 @default.
• W4213439354 hasConceptScore W4213439354C2777803847 @default.
• W4213439354 hasConceptScore W4213439354C2778938600 @default.
• W4213439354 hasConceptScore W4213439354C2781063702 @default.
• W4213439354 hasConceptScore W4213439354C33235085 @default.
• W4213439354 hasConceptScore W4213439354C71924100 @default.
• W4213439354 hasConceptScore W4213439354C86803240 @default.
• W4213439354 hasConceptScore W4213439354C92759361 @default.
• W4213439354 hasConceptScore W4213439354C95444343 @default.
• W4213439354 hasConceptScore W4213439354C98274493 @default.
• W4213439354 hasIssue "5" @default.
• W4213439354 hasLocation W42134393541 @default.
• W4213439354 hasLocation W42134393542 @default.
• W4213439354 hasLocation W42134393543 @default.
• W4213439354 hasOpenAccess W4213439354 @default.
• W4213439354 hasPrimaryLocation W42134393541 @default.
• W4213439354 hasRelatedWork W1699017532 @default.
• W4213439354 hasRelatedWork W1970244915 @default.
• W4213439354 hasRelatedWork W2039541786 @default.
• W4213439354 hasRelatedWork W2077327193 @default.

• next