Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213442080> ?p ?o ?g. }
- W4213442080 endingPage "102274" @default.
- W4213442080 startingPage "102274" @default.
- W4213442080 abstract "Mulberrin (Mul) is a key component of the traditional Chinese medicine Romulus Mori with various biological functions. However, the effects of Mul on liver fibrosis have not been addressed, and thus were investigated in our present study, as well as the underlying mechanisms. Here, we found that Mul administration significantly ameliorated carbon tetrachloride (CCl4)-induced liver injury and dysfunction in mice. Furthermore, CCl4-triggerd collagen deposition and liver fibrosis were remarkably attenuated in mice with Mul supplementation through suppressing transforming growth factor β1 (TGF-β1)/SMAD2/3 signaling pathway. Additionally, Mul treatments strongly restrained the hepatic inflammation in CCl4-challenged mice via blocking nuclear factor-κB (NF-κB) signaling. Importantly, we found that Mul markedly increased liver TRIM31 expression in CCl4-treated mice, accompanied with the inactivation of NOD-like receptor protein 3 (NLRP3) inflammasome. CCl4-triggered hepatic oxidative stress was also efficiently mitigated by Mul consumption via improving nuclear factor E2-related factor 2 (Nrf2) activation. Our in vitro studies confirmed that Mul reduced the activation of human and mouse primary hepatic stellate cells (HSCs) stimulated by TGF-β1. Consistently, Mul remarkably retarded the inflammatory response and reactive oxygen species (ROS) accumulation both in human and murine hepatocytes. More importantly, by using hepatocyte-specific TRIM31 knockout mice (TRIM31Hep-cKO) and mouse primary hepatocytes with Nrf2-knockout (Nrf2KO), we identified that the anti-fibrotic and hepatic protective effects of Mul were TRIM31/Nrf2 signaling-dependent, relieving HSCs activation and liver fibrosis. Therefore, Mul-ameliorated hepatocyte injury contributed to the suppression of HSCs activation by improving TRIM31/Nrf2 axis, thus providing a novel therapeutic strategy for hepatic fibrosis treatment." @default.
- W4213442080 created "2022-02-25" @default.
- W4213442080 creator A5008055004 @default.
- W4213442080 creator A5017078233 @default.
- W4213442080 creator A5018626623 @default.
- W4213442080 creator A5027239754 @default.
- W4213442080 creator A5027813231 @default.
- W4213442080 creator A5031665005 @default.
- W4213442080 creator A5034774874 @default.
- W4213442080 creator A5040658030 @default.
- W4213442080 creator A5051968569 @default.
- W4213442080 creator A5052683420 @default.
- W4213442080 creator A5063820443 @default.
- W4213442080 creator A5085212865 @default.
- W4213442080 creator A5086127329 @default.
- W4213442080 date "2022-05-01" @default.
- W4213442080 modified "2023-10-18" @default.
- W4213442080 title "Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling" @default.
- W4213442080 cites W1988149166 @default.
- W4213442080 cites W1998976242 @default.
- W4213442080 cites W2002039213 @default.
- W4213442080 cites W2007867750 @default.
- W4213442080 cites W2028993208 @default.
- W4213442080 cites W2038879992 @default.
- W4213442080 cites W2057965330 @default.
- W4213442080 cites W2059149677 @default.
- W4213442080 cites W2068619092 @default.
- W4213442080 cites W2118170059 @default.
- W4213442080 cites W2124728669 @default.
- W4213442080 cites W2132951131 @default.
- W4213442080 cites W2146967775 @default.
- W4213442080 cites W2256103742 @default.
- W4213442080 cites W2260903586 @default.
- W4213442080 cites W2402805407 @default.
- W4213442080 cites W2463612608 @default.
- W4213442080 cites W2522054313 @default.
- W4213442080 cites W2540894007 @default.
- W4213442080 cites W2553373758 @default.
- W4213442080 cites W2560356992 @default.
- W4213442080 cites W2562949639 @default.
- W4213442080 cites W2564777109 @default.
- W4213442080 cites W2570170200 @default.
- W4213442080 cites W2585046292 @default.
- W4213442080 cites W2742096481 @default.
- W4213442080 cites W2767062996 @default.
- W4213442080 cites W2782048145 @default.
- W4213442080 cites W2784676168 @default.
- W4213442080 cites W2796699845 @default.
- W4213442080 cites W2800061832 @default.
- W4213442080 cites W2800340823 @default.
- W4213442080 cites W2805876899 @default.
- W4213442080 cites W2806300512 @default.
- W4213442080 cites W2883704382 @default.
- W4213442080 cites W2890324251 @default.
- W4213442080 cites W2890687118 @default.
- W4213442080 cites W2902749307 @default.
- W4213442080 cites W2907234669 @default.
- W4213442080 cites W2917357185 @default.
- W4213442080 cites W2937066557 @default.
- W4213442080 cites W2949359538 @default.
- W4213442080 cites W2967546593 @default.
- W4213442080 cites W3000568230 @default.
- W4213442080 cites W3007626843 @default.
- W4213442080 cites W3008100024 @default.
- W4213442080 cites W3014599953 @default.
- W4213442080 cites W3014893716 @default.
- W4213442080 cites W3037576067 @default.
- W4213442080 cites W3037935764 @default.
- W4213442080 cites W3042653276 @default.
- W4213442080 cites W3045948122 @default.
- W4213442080 cites W3095484986 @default.
- W4213442080 cites W3114284878 @default.
- W4213442080 cites W3137664266 @default.
- W4213442080 cites W879038605 @default.
- W4213442080 cites W985842495 @default.
- W4213442080 doi "https://doi.org/10.1016/j.redox.2022.102274" @default.
- W4213442080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35240537" @default.
- W4213442080 hasPublicationYear "2022" @default.
- W4213442080 type Work @default.
- W4213442080 citedByCount "14" @default.
- W4213442080 countsByYear W42134420802022 @default.
- W4213442080 countsByYear W42134420802023 @default.
- W4213442080 crossrefType "journal-article" @default.
- W4213442080 hasAuthorship W4213442080A5008055004 @default.
- W4213442080 hasAuthorship W4213442080A5017078233 @default.
- W4213442080 hasAuthorship W4213442080A5018626623 @default.
- W4213442080 hasAuthorship W4213442080A5027239754 @default.
- W4213442080 hasAuthorship W4213442080A5027813231 @default.
- W4213442080 hasAuthorship W4213442080A5031665005 @default.
- W4213442080 hasAuthorship W4213442080A5034774874 @default.
- W4213442080 hasAuthorship W4213442080A5040658030 @default.
- W4213442080 hasAuthorship W4213442080A5051968569 @default.
- W4213442080 hasAuthorship W4213442080A5052683420 @default.
- W4213442080 hasAuthorship W4213442080A5063820443 @default.
- W4213442080 hasAuthorship W4213442080A5085212865 @default.
- W4213442080 hasAuthorship W4213442080A5086127329 @default.
- W4213442080 hasBestOaLocation W42134420801 @default.
- W4213442080 hasConcept C102124568 @default.