SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213442765> ?p ?o ?g. }

Showing items 1 to 100 of ±108 with 100 items per page.

W4213442765 abstract "Activation of EGFR is a major risk factor for non-small cell lung cancer (NSCLC). Understanding the molecular events promoting EGFR activation can help us gain more insights into the progression of NSCLC. In this study, we demonstrate that collagen type VIII alpha 1 chain (COL8A1), an extracellular matrix component, was overexpressed in NSCLC. In NSCLC cells, knockdown of COL8A1 suppressed cell growth, cycle progression, and migration, and induced cell apoptosis. While COL8A1 overexpression promoted cell proliferation and inhibited cell apoptosis. In addition, we found that COL8A1 depletion reduced interferon response signaling and downregulated (IFIT1) and interferon-induced proteins with tetratricopeptide repeats 3 (IFIT3). Moreover, we indicated that COL8A1 could upregulate IFIT1 and IFIT3 mediated EGFR activation in vitro and in vivo. Lastly, there was a positive correlation among COL8A1, IFIT1, and IFIT3 expression, and EGFR activity in patients with NSCLC. Overall, our data demonstrate that COL8A1 contributes to NSCLC proliferation and invasion through EGFR activation, dependent on IFIT1 and IFIT3 expression." @default.
W4213442765 created "2022-02-25" @default.
W4213442765 creator A5013938837 @default.
W4213442765 creator A5019927724 @default.
W4213442765 creator A5020949128 @default.
W4213442765 creator A5021503189 @default.
W4213442765 creator A5023914977 @default.
W4213442765 creator A5025708434 @default.
W4213442765 creator A5029103063 @default.
W4213442765 creator A5034162625 @default.
W4213442765 creator A5034255583 @default.
W4213442765 creator A5064441322 @default.
W4213442765 creator A5085468355 @default.
W4213442765 creator A5087333001 @default.
W4213442765 creator A5088930540 @default.
W4213442765 date "2022-02-24" @default.
W4213442765 modified "2023-10-11" @default.
W4213442765 title "COL8A1 Promotes NSCLC Progression Through IFIT1/IFIT3-Mediated EGFR Activation" @default.
W4213442765 cites W1581988395 @default.
W4213442765 cites W1996271871 @default.
W4213442765 cites W2002312256 @default.
W4213442765 cites W2028876212 @default.
W4213442765 cites W2029692425 @default.
W4213442765 cites W2059392901 @default.
W4213442765 cites W2076039408 @default.
W4213442765 cites W2111955351 @default.
W4213442765 cites W2148287035 @default.
W4213442765 cites W2168672282 @default.
W4213442765 cites W2467594508 @default.
W4213442765 cites W2551249557 @default.
W4213442765 cites W2560494360 @default.
W4213442765 cites W2596486024 @default.
W4213442765 cites W2691615730 @default.
W4213442765 cites W2698532714 @default.
W4213442765 cites W2789896349 @default.
W4213442765 cites W2799577770 @default.
W4213442765 cites W2800071778 @default.
W4213442765 cites W2910727851 @default.
W4213442765 cites W2975059055 @default.
W4213442765 cites W2980882443 @default.
W4213442765 cites W2983202017 @default.
W4213442765 cites W2999417355 @default.
W4213442765 cites W3003968102 @default.
W4213442765 cites W3035955877 @default.
W4213442765 cites W3083501712 @default.
W4213442765 doi "https://doi.org/10.3389/fonc.2022.707525" @default.
W4213442765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35280763" @default.
W4213442765 hasPublicationYear "2022" @default.
W4213442765 type Work @default.
W4213442765 citedByCount "2" @default.
W4213442765 countsByYear W42134427652023 @default.
W4213442765 crossrefType "journal-article" @default.
W4213442765 hasAuthorship W4213442765A5013938837 @default.
W4213442765 hasAuthorship W4213442765A5019927724 @default.
W4213442765 hasAuthorship W4213442765A5020949128 @default.
W4213442765 hasAuthorship W4213442765A5021503189 @default.
W4213442765 hasAuthorship W4213442765A5023914977 @default.
W4213442765 hasAuthorship W4213442765A5025708434 @default.
W4213442765 hasAuthorship W4213442765A5029103063 @default.
W4213442765 hasAuthorship W4213442765A5034162625 @default.
W4213442765 hasAuthorship W4213442765A5034255583 @default.
W4213442765 hasAuthorship W4213442765A5064441322 @default.
W4213442765 hasAuthorship W4213442765A5085468355 @default.
W4213442765 hasAuthorship W4213442765A5087333001 @default.
W4213442765 hasAuthorship W4213442765A5088930540 @default.
W4213442765 hasBestOaLocation W42134427651 @default.
W4213442765 hasConcept C104317684 @default.
W4213442765 hasConcept C126322002 @default.
W4213442765 hasConcept C127561419 @default.
W4213442765 hasConcept C173396325 @default.
W4213442765 hasConcept C185592680 @default.
W4213442765 hasConcept C190283241 @default.
W4213442765 hasConcept C2776256026 @default.
W4213442765 hasConcept C502942594 @default.
W4213442765 hasConcept C55493867 @default.
W4213442765 hasConcept C62112901 @default.
W4213442765 hasConcept C71924100 @default.
W4213442765 hasConceptScore W4213442765C104317684 @default.
W4213442765 hasConceptScore W4213442765C126322002 @default.
W4213442765 hasConceptScore W4213442765C127561419 @default.
W4213442765 hasConceptScore W4213442765C173396325 @default.
W4213442765 hasConceptScore W4213442765C185592680 @default.
W4213442765 hasConceptScore W4213442765C190283241 @default.
W4213442765 hasConceptScore W4213442765C2776256026 @default.
W4213442765 hasConceptScore W4213442765C502942594 @default.
W4213442765 hasConceptScore W4213442765C55493867 @default.
W4213442765 hasConceptScore W4213442765C62112901 @default.
W4213442765 hasConceptScore W4213442765C71924100 @default.
W4213442765 hasLocation W42134427651 @default.
W4213442765 hasLocation W42134427652 @default.
W4213442765 hasLocation W42134427653 @default.
W4213442765 hasLocation W42134427654 @default.
W4213442765 hasOpenAccess W4213442765 @default.
W4213442765 hasPrimaryLocation W42134427651 @default.
W4213442765 hasRelatedWork W2904239912 @default.
W4213442765 hasRelatedWork W3016435787 @default.
W4213442765 hasRelatedWork W3048105303 @default.
W4213442765 hasRelatedWork W3103789129 @default.
W4213442765 hasRelatedWork W3127487613 @default.
W4213442765 hasRelatedWork W3157667906 @default.