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• W4213448880 endingPage "138" @default.
• W4213448880 startingPage "127" @default.
• W4213448880 abstract "Benzo[a]pyrene (B[a]P) is a known human carcinogen and plays a major function in the initiation of lung cancer at its first proximity. However, the underlying molecular mechanisms are less well understood. In this study, we investigated the impact of B[a]P treatment on the DNA methylation and mRNA levels of CYP1A1, GSTP1, and GSTM1 in human bronchial epithelial cells (16HBEs), and provide scientific evidence for the mechanism study on the carcinogenesis of B[a]P. We treated 16HBEs with DMSO or concentrations of B[a]P at 1, 2, and 5 mmol/L for 24 h, observed the morphological changes, determined the cell viability, DNA methylation, and mRNA levels of CYP1A1, GSTP1, and GSTM1. Compared to the DMSO controls, B[a]P treatment had significantly increased the neoplastic cell number and cell viability in 16HBEs at all three doses (1, 2, and 5 mmol/L), and had significantly reduced the CYP1A1 and GSTP1 DNA promoter methylation levels. Following B[a]P treatment, the GSTM1 promoter methylation level in 16HBEs was profoundly reduced at low dose group compared to the DMSO controls, yet it was significantly increased at both middle and high dose groups. The mRNA levels of CYP1A1, GSTP1, and GSTM1 were significantly decreased in 16HBEs following B[a]P treatment at all three doses. The findings demonstrate that B[a]P promoted cell proliferation in 16HBEs, which was possibly related to the altered DNA methylations and the inhibited mRNA levels in CYP1A1, GSTP1, and GSTM1." @default.
• W4213448880 created "2022-02-25" @default.
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• W4213448880 date "2022-02-22" @default.
• W4213448880 modified "2023-10-03" @default.
• W4213448880 title "Alterations of DNA methylation and<i>mRNA</i>levels of<i>CYP1A1</i>,<i>GSTP1,</i>and<i>GSTM1</i>in human bronchial epithelial cells induced by benzo[a]pyrene" @default.
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• W4213448880 doi "https://doi.org/10.1177/07482337211069233" @default.
• W4213448880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35193440" @default.
• W4213448880 hasPublicationYear "2022" @default.
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