FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4213451567> ?p ?o ?g. }

• W4213451567 abstract "The increasing incidence of carbapenem-nonsusceptible Enterobacterales as major pathogens in healthcare associated infections (HAIs) is of paramount concern. To implement effective prevention strategies against carbapenem-nonsusceptible Enterobacterales (CnSE) HAIs, it is crucial to identify modifiable factors associated with these infections. We identified risk factors for CnSE-HAIs, and compared clinical outcomes of CnSE-HAI and carbapenem-sensitive Enterobacterales (CSE)-HAI patients.We conducted a multi-centre parallel matched case-control study in two 1700-bedded Singapore acute-care hospitals from 2014-2016. Patients with CnSE-HAIs and CSE-HAIs were compared to a common control group without HAIs (1:1:3 ratio), matched by time-at-risk and patient ward. Carbapenem nonsusceptible was defined as non-susceptibility to either meropenem or imipenem. Presence of healthcare associated infections were defined by the criteria provided by the European Centre for Disease Prevention and Control. Outcomes of CnSE-HAI and CSE-HAI patients were compared using multivariable logistic and cox regression; the models were adjusted for infection and treatment characteristics.Eighty CnSE-HAI and 80 CSE-HAI patients were matched to 240 patients without HAIs. All CRE-HAIs patients had prior antibiotic exposure, with 44 (55.0%) with prior carbapenem exposure. The most common CnSE-HAIs were intra-abdominal infections (28.8%) and pneumonia (23.8%). The most common CnSE species was Klebsiella spp. (63.8%). In the risk factor analysis, presence of drainage devices [adjusted odds ratio (aOR), 2.19; 95% CI, 1.29 - 3.70] and prior carbapenem exposure (aOR,17.09; 95% CI, 3.06 - 95.43) independently predicted CnSE-HAIs. In the crude outcomes analysis, CnSE-HAI patients had higher all-cause in-hospital mortality and longer time to discharge compared to CSE-HAI patients. After adjusting for differences in receipt of antibiotics with reported susceptibility to the Enterobacterales, there was no significant difference in all-cause in-hospital mortality between the two groups (aOR, 1.76; 95% CI, 0.86-3.58). Time to discharge remained significantly longer in patients with CnSE-HAI (adjusted hazard ratio, 0.71; 95% CI, 0.51 - 0.98) after adjusting for disease severity, receipt of antibiotics with reported susceptibility and receipt of appropriate source control.Appropriate management of deep-seated Enterobacterales infections and reducing exposure to carbapenems may reduce risk of CnSE-HAIs in Singapore. Efforts to improve antimicrobial therapy in CnSE-HAI patients may improve patient outcomes." @default.
• W4213451567 created "2022-02-25" @default.
• W4213451567 creator A5001774058 @default.
• W4213451567 creator A5003215465 @default.
• W4213451567 creator A5017974046 @default.
• W4213451567 creator A5028799787 @default.
• W4213451567 creator A5041997002 @default.
• W4213451567 creator A5045792186 @default.
• W4213451567 creator A5054240088 @default.
• W4213451567 creator A5069821308 @default.
• W4213451567 creator A5081032971 @default.
• W4213451567 creator A5083113257 @default.
• W4213451567 date "2022-02-24" @default.
• W4213451567 modified "2023-10-17" @default.
• W4213451567 title "Predictors and Outcomes of Healthcare-Associated Infections Caused by Carbapenem-Nonsusceptible Enterobacterales: A Parallel Matched Case-Control Study" @default.
• W4213451567 cites W1848317103 @default.
• W4213451567 cites W1886444573 @default.
• W4213451567 cites W1967642834 @default.
• W4213451567 cites W1976827275 @default.
• W4213451567 cites W1982240222 @default.
• W4213451567 cites W2007113387 @default.
• W4213451567 cites W2007812259 @default.
• W4213451567 cites W2019448438 @default.
• W4213451567 cites W2057684478 @default.
• W4213451567 cites W2113898837 @default.
• W4213451567 cites W2119498007 @default.
• W4213451567 cites W2130765730 @default.
• W4213451567 cites W2141351444 @default.
• W4213451567 cites W2154692607 @default.
• W4213451567 cites W2162494851 @default.
• W4213451567 cites W2166511722 @default.
• W4213451567 cites W2285316980 @default.
• W4213451567 cites W2337544276 @default.
• W4213451567 cites W2599076725 @default.
• W4213451567 cites W2610735932 @default.
• W4213451567 cites W2618911885 @default.
• W4213451567 cites W2763934038 @default.
• W4213451567 cites W4294116629 @default.
• W4213451567 doi "https://doi.org/10.3389/fcimb.2022.719421" @default.
• W4213451567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35281438" @default.
• W4213451567 hasPublicationYear "2022" @default.
• W4213451567 type Work @default.
• W4213451567 citedByCount "2" @default.
• W4213451567 countsByYear W42134515672022 @default.
• W4213451567 countsByYear W42134515672023 @default.
• W4213451567 crossrefType "journal-article" @default.
• W4213451567 hasAuthorship W4213451567A5001774058 @default.
• W4213451567 hasAuthorship W4213451567A5003215465 @default.
• W4213451567 hasAuthorship W4213451567A5017974046 @default.
• W4213451567 hasAuthorship W4213451567A5028799787 @default.
• W4213451567 hasAuthorship W4213451567A5041997002 @default.
• W4213451567 hasAuthorship W4213451567A5045792186 @default.
• W4213451567 hasAuthorship W4213451567A5054240088 @default.
• W4213451567 hasAuthorship W4213451567A5069821308 @default.
• W4213451567 hasAuthorship W4213451567A5081032971 @default.
• W4213451567 hasAuthorship W4213451567A5083113257 @default.
• W4213451567 hasBestOaLocation W42134515671 @default.
• W4213451567 hasConcept C104317684 @default.
• W4213451567 hasConcept C120665830 @default.
• W4213451567 hasConcept C121332964 @default.
• W4213451567 hasConcept C126322002 @default.
• W4213451567 hasConcept C156957248 @default.
• W4213451567 hasConcept C166888038 @default.
• W4213451567 hasConcept C177713679 @default.
• W4213451567 hasConcept C2776685102 @default.
• W4213451567 hasConcept C2777058267 @default.
• W4213451567 hasConcept C2779375183 @default.
• W4213451567 hasConcept C2779631663 @default.
• W4213451567 hasConcept C501593827 @default.
• W4213451567 hasConcept C547475151 @default.
• W4213451567 hasConcept C55493867 @default.
• W4213451567 hasConcept C61511704 @default.
• W4213451567 hasConcept C71924100 @default.
• W4213451567 hasConcept C86803240 @default.
• W4213451567 hasConcept C89423630 @default.
• W4213451567 hasConcept C94665300 @default.
• W4213451567 hasConceptScore W4213451567C104317684 @default.
• W4213451567 hasConceptScore W4213451567C120665830 @default.
• W4213451567 hasConceptScore W4213451567C121332964 @default.
• W4213451567 hasConceptScore W4213451567C126322002 @default.
• W4213451567 hasConceptScore W4213451567C156957248 @default.
• W4213451567 hasConceptScore W4213451567C166888038 @default.
• W4213451567 hasConceptScore W4213451567C177713679 @default.
• W4213451567 hasConceptScore W4213451567C2776685102 @default.
• W4213451567 hasConceptScore W4213451567C2777058267 @default.
• W4213451567 hasConceptScore W4213451567C2779375183 @default.
• W4213451567 hasConceptScore W4213451567C2779631663 @default.
• W4213451567 hasConceptScore W4213451567C501593827 @default.
• W4213451567 hasConceptScore W4213451567C547475151 @default.
• W4213451567 hasConceptScore W4213451567C55493867 @default.
• W4213451567 hasConceptScore W4213451567C61511704 @default.
• W4213451567 hasConceptScore W4213451567C71924100 @default.
• W4213451567 hasConceptScore W4213451567C86803240 @default.
• W4213451567 hasConceptScore W4213451567C89423630 @default.
• W4213451567 hasConceptScore W4213451567C94665300 @default.
• W4213451567 hasFunder F4320320761 @default.
• W4213451567 hasFunder F4320334737 @default.
• W4213451567 hasLocation W42134515671 @default.
• W4213451567 hasLocation W42134515672 @default.
• W4213451567 hasLocation W42134515673 @default.

• next